CAS 28822-58-4

3-Isobutil-1-metilxantina

Descrizione:

3-Isobutil-1-metilxantina (CAS 28822-58-4) è un derivato della xantina che presenta proprietà simili alla caffeina e alla teobromina, agendo principalmente come inibitore della fosfodiesterasi. Questo composto è caratterizzato dalle sue caratteristiche strutturali, che includono un nucleo di xantina con gruppi isobutili e metilici in posizioni specifiche, contribuendo alla sua attività biologica. È noto per i suoi effetti stimolanti, migliorando la vigilanza e la funzione cognitiva, ed è spesso studiato per le sue potenziali applicazioni terapeutiche in condizioni come l'asma e altri disturbi respiratori grazie alle sue proprietà broncodilatatrici. Il composto è tipicamente solubile in solventi organici e mostra una stabilità moderata in condizioni di laboratorio standard. Il suo profilo farmacologico include effetti sui recettori dell'adenosina, che svolgono un ruolo cruciale in vari processi fisiologici. Come molti derivati della xantina, può anche avere implicazioni nella ricerca relativa ai processi metabolici e alla regolazione dell'energia. Devono essere osservate precauzioni di sicurezza e di manipolazione, come per qualsiasi sostanza chimica, per mitigare i potenziali rischi per la salute.

Formula: C₁₀H₁₄N₄O₂

InChI: InChI=1S/C10H14N4O2/c1-6(2)4-14-8-7(11-5-12-8)9(15)13(3)10(14)16/h5-6H,4H2,1-3H3,(H,11,12)

InChI key: InChIKey=APIXJSLKIYYUKG-UHFFFAOYSA-N

SMILES: C(C(C)C)N1C2=C(C(=O)N(C)C1=O)NC=N2

Sinonimi:

• 1-Methyl-3-(2-methylpropyl)-2,3,6,9-tetrahydro-1H-purine-2,6-dione
• 1-Methyl-3-isobutylxanthine
• 1H-Purine-2,6-dione, 3,9-dihydro-1-methyl-3-(2-methylpropyl)-
• 3,7-Dihydro-3-isobutyl-1-methyl-1H-purin-2,6-dion
• 3,7-dihidro-3-isobutil-1-metil-1H-purina-2,6-diona
• 3,7-dihydro-3-isobutyl-1-methyl-1H-purine-2,6-dione
• 3,9-Dihydro-1-methyl-3-(2-methylpropyl)-1H-purine-2,6-dione
• 3-Isobutyl-1-methyl-1H-purine-2,6(3H,7H)-dione
• 3-Isobutyl-1-methyl-3,7-dihydro-1H-purine-2,6-dione
• 3-Isobutyl-1-methylxanthine
• IMX
• Ibmx
• Isobutylmethylxanthine
• Methylisobutylxanthine
• Nsc 165960
• Sc 2964
• Xanthine, 3-isobutyl-1-methyl-

3-Isobutyl-1-methylxanthine

CAS: 28822-58-4

3-Isobutyl-1-methylxanthine is used in inhibition of phenylephrine-induced release of 5-hydroxytryptamine from neuroendocrine epithelial cells of the airway mucosa (IC50 = 1.3 uM). Also inhibits ion channels in the neuromuscular junction, GH3 cells, and vascular smooth muscle cells. Inhibits the gro

Formula: C₁₀H₁₄N₄O₂

Colore e forma: Solid, White

Peso molecolare: 222.25

Ref: 02-J64598

1H-Purine-2,6-dione, 3,9-dihydro-1-methyl-3-(2-methylpropyl)-

CAS: 28822-58-4

Formula: C₁₀H₁₄N₄O₂

Purezza: 99%

Colore e forma: Solid

Peso molecolare: 222.2438

Ref: IN-DA002WN3

3-Isobutyl-1-methylxanthine

CAS: 28822-58-4

Formula: C₁₀H₁₄N₄O₂

Purezza: ≥ 99.0%

Colore e forma: White solid

Peso molecolare: 222.24

Ref: 7W-GL2425

3-Isobutyl-1-Methylxanthine

CAS: 28822-58-4

3-Isobutyl-1-Methylxanthine

Purezza: 98%

Peso molecolare: 222.24g/mol

Ref: 54-OR1011019

IBMX

CAS: 28822-58-4

IBMX

Purezza: ≥98%

Peso molecolare: 222.24g/mol

Ref: 54-BUP15795

IBMX

CAS: 28822-58-4

IBMX (Methylisobutylxanthine) is a broad-spectrum phosphodiesterase (PDE) inhibitor with inhibitory activity against PDE3, PDE4, and PDE5 (IC50=6.5/26.3/31.7 μM

Formula: C₁₀H₁₄N₄O₂

Purezza: 98% - >99.99%

Colore e forma: Off-White

Peso molecolare: 222.24

Ref: TM-T1713

IBMX

CAS: 28822-58-4

Formula: C₁₀H₁₄N₄O₂

Peso molecolare: 222.25

Ref: 4Z-K-031077

3-Isobutyl-1-methylxanthine

CAS: 28822-58-4

Applications A nonspecific inhibitor of phosphodiesterases.
References Beavo., J.A., et al.: Mol. Pharmacol., 6, 597 (1970), Scamps, F., et al.: Eur. J. Pharmacol., 224, 119 (1993)

Formula: C₁₀H₁₄N₄O₂

Colore e forma: Neat

Peso molecolare: 222.24

Ref: TR-I785000

IBMX - Bio-X ™

Prodotto controllato

CAS: 28822-58-4

IBMX is a competitive non-selective phosphodiesterase inhibitor that raises cAMP and activates PKA. It also inhibits TNFα and leukotriene synthesis. This chemical compound reduces inflammation and is an adenosine receptor antagonist.

IBMX is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready to use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Formula: C₁₀H₁₄N₄O₂

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 222.24 g/mol

Ref: 3D-BI164529

3-Isobutyl-1-methylxanthine

Prodotto controllato

CAS: 28822-58-4

A non-specific inhibitor of cAMP and cGMP phosphodiesterases (PDEs) with IC50 values between 2 and 50 µM. 2-isobutyl-1-methylxanthine (IBMX) has also been found to inhibit phenylephrine-induced 5-HT release by neuroendocrine epithelial cells and IBMX-mediated increase in cAMP and upregulation of Ca2+ channels promotes neuronal differentiation. Additionally IBMX stimulates secretion of thyroid hormones, resulting in cAMP-mediated activation of glycogenolysis and reduced glycogen storage.

Formula: C₁₀H₁₄N₄O₂

Colore e forma: Slightly Yellow Powder

Peso molecolare: 222.24 g/mol

Ref: 3D-FI24659

3-Isobutyl-1-methylxanthine

Prodotto controllato

CAS: 28822-58-4

A non-specific inhibitor of cAMP and cGMP phosphodiesterases (PDEs) with IC50 values between 2 and 50 µM. 2-Isobutyl-1-methylxanthine (IBMX) has also been found to inhibit phenylephrine-induced 5-HT release by neuroendocrine epithelial cells and IBMX-mediated increase in cAMP and upregulation of Ca2+ channels promotes neuronal differentiation. Additionally IBMX stimulates secretion of thyroid hormones, resulting in cAMP-mediated activation of glycogenolysis and reduced glycogen storage.

Formula: C₁₀H₁₄N₄O₂

Peso molecolare: 222.24 g/mol

Ref: 3D-J-640140

IBMX

CAS: 28822-58-4

Formula: C₁₀H₁₄N₄O₂

Purezza: 98%

Colore e forma: Solid, Light yellow powder

Peso molecolare: 222.248

Ref: 10-M01902