CAS 290297-26-6

Netupitant

Descrizione:

Netupitant è un antagonista selettivo del recettore neurochinina-1 (NK1) utilizzato principalmente nella prevenzione di nausea e vomito associati alla chemioterapia. Spesso viene combinato con palonosetron, un antagonista del recettore 5-HT3, per aumentarne l'efficacia. La formula molecolare di Netupitant indica che contiene atomi di carbonio, idrogeno, azoto e ossigeno, riflettendo la sua natura organica. Questo composto è caratterizzato dalla sua alta affinità per il recettore NK1, che gioca un ruolo cruciale nella risposta emetica. Netupitant viene tipicamente somministrato per via orale ed è ben assorbito nel tratto gastrointestinale. La sua farmacocinetica mostra una emivita relativamente lunga, consentendo una somministrazione una volta al giorno. La sostanza è generalmente ben tollerata, con effetti collaterali comuni che includono affaticamento, stitichezza e mal di testa. Grazie al suo meccanismo d'azione, Netupitant è particolarmente efficace nella gestione della nausea e del vomito indotti dalla chemioterapia, rendendolo un'opzione terapeutica preziosa in contesti oncologici.

Formula: C₃₀H₃₂F₆N₄O

InChI: InChI=1S/C30H32F6N4O/c1-19-8-6-7-9-23(19)24-17-26(40-12-10-38(4)11-13-40)37-18-25(24)39(5)27(41)28(2,3)20-14-21(29(31,32)33)16-22(15-20)30(34,35)36/h6-9,14-18H,10-13H2,1-5H3

InChI key: InChIKey=WAXQNWCZJDTGBU-UHFFFAOYSA-N

SMILES: N(C(C(C)(C)C1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1)=O)(C)C=2C(=CC(=NC2)N3CCN(C)CC3)C4=C(C)C=CC=C4

Sinonimi:

• 2-[3,5-Bis(trifluoromethyl)phenyl]-N-[6-(4-methylpiperazin-1-yl)-4-o-tolylpyridin-3-yl]-N-methylisobutyramide
• Benzeneacetamide, N,alpha,alpha-trimethyl-N-(4-(2-methylphenyl)-6-(4-methyl-1-piperazinyl)-3-pyridinyl)-3,5-bis(trifluoromethyl)-
• Benzeneacetamide, N,α,α-trimethyl-N-[4-(2-methylphenyl)-6-(4-methyl-1-piperazinyl)-3-pyridinyl]-3,5-bis(trifluoromethyl)-
• N,α,α-Trimethyl-N-[4-(2-methylphenyl)-6-(4-methyl-1-piperazinyl)-3-pyridinyl]-3,5-bis(trifluoromethyl)benzeneacetamide
• Netupitan
• Netupitant
• Ro 67-31898/000

Benzeneacetamide, N,α,α-trimethyl-N-[4-(2-methylphenyl)-6-(4-methyl-1-piperazinyl)-3-pyridinyl]-3,5-bis(trifluoromethyl)-

CAS: 290297-26-6

Formula: C₃₀H₃₂F₆N₄O

Purezza: 99%

Colore e forma: Solid

Peso molecolare: 578.5917

Ref: IN-DA002V9C

Netupitant

CAS: 290297-26-6

Netupitant

Purezza: ≥98%

Peso molecolare: 578.59g/mol

Ref: 54-BUP13389

2-(3,5-Bis(Trifluoromethyl)Phenyl)-N,2-Dimethyl-N-(6-(4-Methylpiperazin-1-Yl)-4-(O-Tolyl)Pyridin-3-Yl)Propanamide

CAS: 290297-26-6

2-(3,5-Bis(Trifluoromethyl)Phenyl)-N,2-Dimethyl-N-(6-(4-Methylpiperazin-1-Yl)-4-(O-Tolyl)Pyridin-3-Yl)Propanamide

Purezza: 99%

Peso molecolare: 578.59g/mol

Ref: 54-PC109174

Netupitant

CAS: 290297-26-6

Formula: C₃₀H₃₂F₆N₄O

Colore e forma: White To Off-White Solid

Peso molecolare: 578.60

Ref: 4Z-N-075001

NETUPITANT

CAS: 290297-26-6

Purezza: 95%

Peso molecolare: 578.60302734375

Ref: 10-F856948

Netupitant

CAS: 290297-26-6

Netupitant (CID 6451149) is a specific neurokinin 1 (NK1) receptor antagonist (Ki: 0.95 nM).

Formula: C₃₀H₃₂F₆N₄O

Purezza: 99.43%

Colore e forma: Solid

Peso molecolare: 578.59

Ref: TM-T6905

Netupitant

Prodotto controllato

CAS: 290297-26-6

Applications Netupitant is a potent and selective neurokinin-1 receptor (NK1) receptor antagonist. It is achiral and orally active.
References Hoffmann, T., et al.: Bioorg. Med. Chem. Lett., 16, 1362 (2006); Di Fabio, R., et al.: Bioorg. Med. Chem., 21, 6264 (2013)

Formula: C₃₀H₃₂F₆N₄O

Colore e forma: Neat

Peso molecolare: 578.59

Ref: TR-N390950

Netupitant

CAS: 290297-26-6

Netupitant is an antiemetic drug that is used to treat bowel disease. It has been shown in a two-way crossover study to have biological properties in the treatment of disease activity. Netupitant inhibits the neurokinin-1 receptor and matrix effect, which are responsible for the development of cancerous cells. The drug also has inhibitory properties on p-gp substrates and netupitant, which prevents it from being absorbed by the gastrointestinal tract. This allows netupitant to be transported through the blood-brain barrier into malignant brain tumours, where it can act as a cytotoxic agent.

Purezza: Min. 95%

Ref: 3D-FN103430