CAS 292633-16-0

Ac-Leu-Glu-His-Asp-AMC

Descrizione:

Ac-Leu-Glu-His-Asp-AMC, con il numero CAS 292633-16-0, è un peptide sintetico che funge da substrato per vari enzimi proteolitici, in particolare nella ricerca biochimica e negli saggi. Questo composto è caratterizzato dalla sua sequenza di amminoacidi: leucina acetilata (Ac-Leu), acido glutammico (Glu), istidina (His), acido aspartico (Asp), seguito dal gruppo fluorogenico AMC (7-amino-4-metilcumarina). L'acetilazione all'estremità N-terminale ne migliora la stabilità e la solubilità, mentre il gruppo AMC consente la rilevazione della fluorescenza dopo la scissione da parte degli enzimi, rendendolo utile per studiare l'attività delle proteasi. La struttura del peptide contribuisce alla sua specificità e reattività, consentendo ai ricercatori di indagare la cinetica e i meccanismi in vari contesti biologici. Inoltre, la presenza di catene laterali cariche e polari negli amminoacidi influenza le sue interazioni in soluzione, influenzando il suo comportamento generale negli saggi biochimici.

Formula: C₃₃H₄₁N₇O₁₁

Sinonimi:

• L-a-Asparagine, N-acetyl-L-leucyl-L-a-glutamyl-L-histidyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-

N-Acetyl-Leu-Glu-His-Asp-7-amino-4-methylcoumarin

CAS: 292633-16-0

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Sci

Formula: C₃₃H₄₁N₇O₁₁

Peso molecolare: 711.72

Ref: 02-J66335

Ac-LEHD-AMC

CAS: 292633-16-0

Ac-LEHD-AMC, a fluorogenic caspase-9 substrate, releases fluorescent AMC upon cleavage, aiding caspase-9 activity measurement.

Formula: C₃₃H₄₁N₇O₁₁

Colore e forma: Solid

Peso molecolare: 711.729

Ref: TM-T36342

Ac-Leu-Glu-His-Asp-MCA

CAS: 292633-16-0

Ac-Leu-Glu-His-Asp-MCA is a synthetic peptide that is used as a research tool. The peptide has been shown to bind to the alpha subunit of the nicotinic acetylcholine receptor, which is responsible for binding acetylcholine and transmitting nerve impulses. Ac-Leu-Glu-His-Asp-MCA activates the receptor by mimicking the effects of acetylcholine. Acetylcholine binding to the alpha subunit causes an influx of sodium ions into the cell, which leads to depolarization and an action potential. This synthetic peptide also binds to other types of receptors, including those for serotonin, dopamine, and adrenaline. Acetylcholine binding to these receptors leads to neurotransmitter release.

Formula: C₃₃H₄₁N₇O₁₁

Purezza: Min. 95%

Peso molecolare: 711.72 g/mol

Ref: 3D-MCA-3198-V

Ac-Leu-Glu-His-Asp-AMC trifluoroacetate salt

CAS: 292633-16-0

Ac-Leu-Glu-His-Asp-AMC trifluoroacetate salt is a synthetic peptide that is derived from the amino acid sequence of caspases. Ac-Leu-Glu-His-Asp-AMC trifluoroacetate salt induces apoptosis in insect and E. coli cells by protease activity, which leads to cell death. The sequence of this peptide is found in Drosophila melanogaster and has been shown to induce apoptosis in insect cells. Caspases are enzymes that regulate apoptosis and play a key role in cell death.

Formula: C₃₃H₄₁N₇O₁₁

Purezza: Min. 95%

Peso molecolare: 711.72 g/mol

Ref: 3D-FA110585