CAS 2962941-25-7

FGFR-IN-13

Formula: C₂₃H₂₁N₅O₃

Sinonimi:

• FGFR-IN-13

FGFR-IN-13

CAS: 2962941-25-7

FGFR-IN-13 (compound III-30), an irreversible covalent inhibitor of the fibroblast growth factor receptor (FGFR), effectively modulates signaling through FGFR1 (IC 50 = 0.20 ± 0.02 nM) and FGFR4 (IC 50 = 0.40 ± 0.03 nM). It suppresses the expression of crucial proteins such as total-PARP and Bcl-2, while enhancing the expression of Cleaved-PARP and Bax in a dose-dependent manner. Notably, FGFR-IN-13 demonstrates considerable antitumor and oral activity [1].

Formula: C₂₃H₂₁N₅O₃

Peso molecolare: 415.44

Ref: TM-T86425