CAS 29767-20-2

Teniposide

Descrizione:

Teniposide, con il numero CAS 29767-20-2, è un derivato semisintetico della podofilotossina, utilizzato principalmente come agente antineoplastico nella terapia del cancro. Funziona inibendo la topoisomerasi II, un enzima cruciale per la replicazione e riparazione del DNA, inducendo così danni al DNA e apoptosi nelle cellule cancerose a rapida divisione. Teniposide viene tipicamente somministrato per via endovenosa ed è indicato per il trattamento di varie malignità, inclusi alcuni tipi di leucemia e tumori solidi. Il composto è caratterizzato dalla sua complessa struttura chimica, che include un gruppo fenolico e un legame etereo, contribuendo alla sua attività biologica. È generalmente solubile in solventi organici, ma ha una solubilità limitata in acqua. Gli effetti collaterali possono includere mielosoppressione, disturbi gastrointestinali e reazioni di ipersensibilità. A causa dei suoi potenti effetti e della potenziale tossicità, Teniposide è solitamente prescritto sotto stretta supervisione medica, con attento monitoraggio della risposta del paziente e degli effetti collaterali durante il trattamento.

Formula: C₃₂H₃₂O₁₃S

InChI: InChI=1S/C32H32O13S/c1-37-19-6-13(7-20(38-2)25(19)33)23-14-8-17-18(42-12-41-17)9-15(14)28(16-10-39-30(36)24(16)23)44-32-27(35)26(34)29-21(43-32)11-40-31(45-29)22-4-3-5-46-22/h3-9,16,21,23-24,26-29,31-35H,10-12H2,1-2H3/t16-,21+,23+,24-,26+,27+,28+,29+,31+,32-/m0/s1

InChI key: InChIKey=NRUKOCRGYNPUPR-QBPJDGROSA-N

SMILES: O=C1[C@@]2([C@@H](C=3C([C@@H](O[C@@H]4O[C@]5([C@]([C@H](O)[C@H]4O)(O[C@@H](OC5)C6=CC=CS6)[H])[H])[C@]2(CO1)[H])=CC7=C(C3)OCO7)C8=CC(OC)=C(O)C(OC)=C8)[H]

Sinonimi:

• (5R,5aR,8aR,9S)-5,8,8a,9-Tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-9-[[4,6-O-[(R)-2-thienylmethylene]-β-<span class="text-smallcaps">D</span>-glucopyranosyl]oxy]furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one
• EPT
• Epipodophyllotoxin, 4'-demethyl-, 9-(4,6-O-2-thenylidene-β-D-glucopyranoside)
• Epipodophyllotoxin, 4′-demethyl-, 9-(4,6-O-2-thenylidene-β-<span class="text-smallcaps">D</span>-glucopyranoside)
• Furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-9-[[4,6-O-(2-thienylmethylene)-β-D-glucopyranosyl]oxy]-, [5R-[5α,5aβ,8aα,9β(R*)]]-
• Furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-9-[[4,6-O-(2-thienylmethylene)-β-<span class="text-smallcaps">D</span>-glucopyranosyl]oxy]-, [5R-[5α,5aβ,8aα,9β(R*)]]-
• Furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-9-[[4,6-O-[(R)-2-thienylmethylene]-β-<span class="text-smallcaps">D</span>-glucopyranosyl]oxy]-, (5R,5aR,8aR,9S)-
• Nsc 122819
• Pyrano[3,2-d]-1,3-dioxin, furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one deriv.
• S 122819
• Teniposid
• Teniposide
• Teniposido
• Tenoposide
• Vehem
• Vehem-Sandoz
• Vm 26
• Vumon
• 4’-demethylepipodophyllotoxin9-(4,6-o-2-thenylidene-beta-d-glucopyranoside)
• 4’-demethyl1-o-(4,6-o,o-(2-thenylidene)-beta-d-glucopyranosyl)epipodophylloto
• (5R,5aR,8aR,9S)-5,8,8a,9-Tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-9-[[4,6-O-[(R)-2-thienylmethylene]-β-D-glucopyranosyl]oxy]furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one
• 4’-demethyl-epipodophyllotoxin-beta-d-thenylidene-glucoside
• Furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-9-[[4,6-O-(2-thienylmethylene)-β-D-glucopyranosyl]oxy]-, [5R-[5α,5aβ,8aα,9β(R*)]]-
• (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl 4,6-O-(thiophen-2-ylmethylidene)hexopyranoside
• (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl 4,6-O-(thiophen-2-ylmethylidene)-beta-D-glucopyranoside
• 4’-demethyl1-o-(4,6-o,o-(2-thenylidene)-beta-d-glucopyranosyl)epipodophyllot
• (8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl (4xi)-4,6-O-(thiophen-2-ylmethylidene)-beta-D-xylo-hexopyranoside
• 3’,4’:6,7]naphtho[2,3-d]-1,3-dioxol-6(5ah)-one
• (8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl 4,6-O-(thiophen-2-ylmethylidene)-beta-D-glucopyranoside
• 4’-demethylepipodophyllotoxin9-(4,6-o-2-thenylidene-bata-d-glucopyranoside.
• 4’-demethyl-epipodophyllotoxin-beta-d-thenylidene-glucosid
• 4’-demethylepipodophyllotoxin-beta-d-thenylidineglucoside

Teniposide

CAS: 29767-20-2

Formula: C₃₂H₃₂O₁₃S

Purezza: >98.0%(HPLC)

Colore e forma: White to Almost white powder to crystaline

Peso molecolare: 656.66

Ref: 3B-T3109

5-[[(6R)-7,8-dihydroxy-2-thiophen-2-yl-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxin-6-yl]oxy]-9-(4-hydroxy-3,5-dimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[6,5-f][1,3]benzodioxol-8-one

CAS: 29767-20-2

Formula: C₃₂H₃₂O₁₃S

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 656.6537

Ref: IN-DA00I5IB

Teniposide

CAS: 29767-20-2

Teniposide (VM26), a semisynthetic derivative of podophyllotoxin with antitumor activity, inhibits DNA synthesis by forming a complex with topoisomerase II and

Formula: C₃₂H₃₂O₁₃S

Purezza: 97.7% - 99.45%

Colore e forma: White Or Off-White Crystalline Powder

Peso molecolare: 656.65

Ref: TM-T1523

Teniposide

CAS: 29767-20-2

Teniposide

Purezza: ≥95%

Peso molecolare: 656.65g/mol

Ref: 54-BUP13995

Teniposide

CAS: 29767-20-2

Formula: C₃₂H₃₂O₁₃S

Purezza: ≥ 98.0%

Colore e forma: White to off-white powder

Peso molecolare: 656.65

Ref: 7W-GP2668

Teniposide

CAS: 29767-20-2

Formula: C₃₂H₃₂O₁₃S

Colore e forma: White To Off-White Solid

Peso molecolare: 656.66

Ref: 4Z-T-521

(5R,5aR,8aR,9S)-9-(((2R,4aR,6R,7R,8R,8aS)-7,8-DihydrOxy-2-(Thiophen-2-yl)Hexahydropyrano[3,2-d][1,3]Dioxin-6-yl)Oxy)-5-(4-hydrOxy-3,5-dimethOxyphenyl)-5,5a,8a,9-Tetrahydrofuro[3,4:6,7]Naphtho[2,3-d][1

CAS: 29767-20-2

(5R,5aR,8aR,9S)-9-(((2R,4aR,6R,7R,8R,8aS)-7,8-DihydrOxy-2-(Thiophen-2-yl)Hexahydropyrano[3,2-d][1,3]Dioxin-6-yl)Oxy)-5-(4-hydrOxy-3,5-dimethOxyphenyl)-5,5a,8a,9-Tetrahydrofuro[3,4:6,7]Naphtho[2,3-d][1

Purezza: 98%

Peso molecolare: 656.65g/mol

Ref: 54-OR1026151

Teniposide

CAS: 29767-20-2

Type II topoisomerase inhibitor

Formula: C₃₂H₃₂O₁₃S

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 656.65 g/mol

Ref: 3D-FT09381

Teniposide - Bio-X ™

CAS: 29767-20-2

Teniposide is a cytotoxic drug that is used in the treatment of refractory childhood acute lymphoblastic leukemia. It has antitumour activity. It is a type II topoisomerase inhibitor. This drug inhibits DNA synthesis by forming a complex with topoisomerase II and DNA.

Formula: C₃₂H₃₂O₁₃S

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 656.65 g/mol

Ref: 3D-BT164452

Teniposide

Prodotto controllato

CAS: 29767-20-2

Stability Hygroscopic
Applications A semi-synthetic derivative of Podophyllotoxin. Antineoplastic.
References Stahlen, H., Eur. J. Cancer, 6, 303 (1970), Hacker, M., et al.: Cancer Res., 37, 3287 (1977), Clark, P.I., et al.: Clin. Pharmacokinet., 12, 223 (1987),

Formula: C₃₂H₃₂O₁₃S

Colore e forma: Neat

Peso molecolare: 656.65

Ref: TR-T018400

Teniposide (DISCONTINUED)

CAS: 29767-20-2

Other glycosides, natural or reproduced by synthesis, a

Formula: C₃₂H₃₂O₁₃S

Colore e forma: Powder

Peso molecolare: 656.15636

Ref: 45-1643736