CAS 29767-20-2: Teniposide

Descrizione:Teniposide, con il numero CAS 29767-20-2, è un derivato semisintetico della podofilotossina, utilizzato principalmente come agente antineoplastico nella terapia del cancro. Funziona inibendo la topoisomerasi II, un enzima cruciale per la replicazione e riparazione del DNA, inducendo così danni al DNA e apoptosi nelle cellule cancerose a rapida divisione. Teniposide viene tipicamente somministrato per via endovenosa ed è indicato per il trattamento di varie malignità, inclusi alcuni tipi di leucemia e tumori solidi. Il composto è caratterizzato dalla sua complessa struttura chimica, che include un gruppo fenolico e un legame etereo, contribuendo alla sua attività biologica. È generalmente solubile in solventi organici, ma ha una solubilità limitata in acqua. Gli effetti collaterali possono includere mielosoppressione, disturbi gastrointestinali e reazioni di ipersensibilità. A causa dei suoi potenti effetti e della potenziale tossicità, Teniposide è solitamente prescritto sotto stretta supervisione medica, con attento monitoraggio della risposta del paziente e degli effetti collaterali durante il trattamento.

Formula:C₃₂H₃₂O₁₃S

InChI:InChI=1S/C32H32O13S/c1-37-19-6-13(7-20(38-2)25(19)33)23-14-8-17-18(42-12-41-17)9-15(14)28(16-10-39-30(36)24(16)23)44-32-27(35)26(34)29-21(43-32)11-40-31(45-29)22-4-3-5-46-22/h3-9,16,21,23-24,26-29,31-35H,10-12H2,1-2H3/t16-,21+,23+,24-,26+,27+,28+,29+,31+,32-/m0/s1

InChI key:InChIKey=NRUKOCRGYNPUPR-QBPJDGROSA-N

SMILES:O=C1OCC2C(OC3OC4COC(OC4C(O)C3O)C=5SC=CC5)C6=CC=7OCOC7C=C6C(C8=CC(OC)=C(O)C(OC)=C8)C12

Sinonimi:
(5R,5aR,8aR,9S)-5,8,8a,9-Tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-9-[[4,6-O-[(R)-2-thienylmethylene]-β-D-glucopyranosyl]oxy]furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one
EPT
Epipodophyllotoxin, 4'-demethyl-, 9-(4,6-O-2-thenylidene-β-D-glucopyranoside)
Epipodophyllotoxin, 4′-demethyl-, 9-(4,6-O-2-thenylidene-β-D-glucopyranoside)
Furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-9-[[4,6-O-(2-thienylmethylene)-β-D-glucopyranosyl]oxy]-, [5R-[5α,5aβ,8aα,9β(R*)]]-
Furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-9-[[4,6-O-(2-thienylmethylene)-β-D-glucopyranosyl]oxy]-, [5R-[5α,5aβ,8aα,9β(R*)]]-
Furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-9-[[4,6-O-[(R)-2-thienylmethylene]-β-D-glucopyranosyl]oxy]-, (5R,5aR,8aR,9S)-
Nsc 122819
Pyrano[3,2-d]-1,3-dioxin, furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one deriv.
S 122819
Vedi altri sinonimi
Teniposid
Teniposide
Teniposido
Tenoposide
Vehem
Vehem-Sandoz
Vm 26
Vumon
4’-demethylepipodophyllotoxin9-(4,6-o-2-thenylidene-beta-d-glucopyranoside)
4’-demethyl1-o-(4,6-o,o-(2-thenylidene)-beta-d-glucopyranosyl)epipodophylloto
(5R,5aR,8aR,9S)-5,8,8a,9-Tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-9-[[4,6-O-[(R)-2-thienylmethylene]-β-D-glucopyranosyl]oxy]furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one
4’-demethyl-epipodophyllotoxin-beta-d-thenylidene-glucoside
Furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-9-[[4,6-O-(2-thienylmethylene)-β-D-glucopyranosyl]oxy]-, [5R-[5α,5aβ,8aα,9β(R*)]]-
(5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl 4,6-O-(thiophen-2-ylmethylidene)hexopyranoside
(5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl 4,6-O-(thiophen-2-ylmethylidene)-beta-D-glucopyranoside
4’-demethyl1-o-(4,6-o,o-(2-thenylidene)-beta-d-glucopyranosyl)epipodophyllot
(8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl (4xi)-4,6-O-(thiophen-2-ylmethylidene)-beta-D-xylo-hexopyranoside
3’,4’:6,7]naphtho[2,3-d]-1,3-dioxol-6(5ah)-one
(8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl 4,6-O-(thiophen-2-ylmethylidene)-beta-D-glucopyranoside
4’-demethylepipodophyllotoxin9-(4,6-o-2-thenylidene-bata-d-glucopyranoside.
4’-demethyl-epipodophyllotoxin-beta-d-thenylidene-glucosid
4’-demethylepipodophyllotoxin-beta-d-thenylidineglucoside
Furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-9-[[4,6-O-[(R)-2-thienylmethylene]-β-D-glucopyranosyl]oxy]-, (5R,5aR,8aR,9S)-

11 prodottitrovati.

Dati del prodotto	Purezza	Fascia di prezzo	Consegna prevista
Teniposide REF: 3B-T3109CAS: 29767-20-2	>98.0%(HPLC)	57,00 €~181,00 €	Lun 07 Apr 25
5-[[(6R)-7,8-dihydroxy-2-thiophen-2-yl-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxin-6-yl]oxy]-9-(4-hydroxy-3,5-dimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[6,5-f][1,3]benzodioxol-8-one REF: IN-DA00I5IBCAS: 29767-20-2	98%	47,00 €~543,00 €	Lun 14 Apr 25
Teniposide REF: TM-T1523CAS: 29767-20-2	97.70% - 99.45%	59,00 €~222,00 €	Lun 14 Apr 25
Teniposide REF: 4Z-T-521CAS: 29767-20-2	- - -	Prezzo su richiesta	Mar 15 Apr 25
Teniposide REF: 54-BUP13995CAS: 29767-20-2	97.84%	92,00 €~758,00 €	Mar 15 Apr 25
(5R,5aR,8aR,9S)-9-(((2R,4aR,6R,7R,8R,8aS)-7,8-DihydrOxy-2-(Thiophen-2-yl)Hexahydropyrano[3,2-d][1,3]Dioxin-6-yl)Oxy)-5-(4-hydrOxy-3,5-dimethOxyphenyl)-5,5a,8a,9-Tetrahydrofuro[3,4:6,7]Naphtho[2,3-d][1 REF: 54-OR1026151CAS: 29767-20-2	98%	93,00 €~1.500,00 €	Mar 15 Apr 25
Teniposide REF: 7W-GP2668CAS: 29767-20-2	≥ 98.0%	49,00 €~193,00 €	Lun 21 Apr 25
Teniposide REF: 3D-FT09381CAS: 29767-20-2	Min. 95%	152,00 €~879,00 €	Ven 25 Apr 25
Teniposide - Bio-X ™ REF: 3D-BT164452CAS: 29767-20-2	Min. 95%	147,00 €	Ven 25 Apr 25
Teniposide REF: TR-T018400CAS: 29767-20-2	- - -	99,00 €~247,00 €	Mar 27 Mag 25
Teniposide (PLANNED TO BE DISCONTINUED) REF: 45-1643736CAS: 29767-20-2	- - -	- - -	Prodotto fuori produzione