CAS 29782-68-1

Silidianina

Descrizione:

Silidianina è un composto di flavonolignano derivato principalmente dalla pianta del cardo mariano, Silybum marianum. È uno dei costituenti attivi della silimarina, un complesso di flavonoidi noto per le sue proprietà epatoprotettive. Silidianina mostra attività antiossidante, che aiuta a neutralizzare i radicali liberi e ridurre lo stress ossidativo nelle cellule epatiche. Questo composto è spesso studiato per i suoi potenziali effetti terapeutici nelle malattie epatiche, tra cui epatite e cirrosi, poiché può promuovere la rigenerazione del fegato e migliorare la funzione epatica. Inoltre, Silidianina è stato indagato per i suoi effetti anti-infiammatori e citoprotettivi, contribuendo ai suoi benefici complessivi per la salute. La sostanza è tipicamente caratterizzata dalla sua solubilità in solventi organici e dalla limitata solubilità in acqua, comune a molti flavonoidi. Le sue proprietà farmacologiche e il profilo di sicurezza la rendono un argomento di interesse nella medicina erboristica e negli integratori alimentari destinati a supportare la salute del fegato.

Formula: C₂₅H₂₂O₁₀

InChI: InChI=1S/C25H22O10/c1-33-16-4-9(2-3-14(16)27)18-11-7-12(20-13(18)8-34-25(20,32)24(11)31)23-22(30)21(29)19-15(28)5-10(26)6-17(19)35-23/h2-7,11,13,18,20,22-23,26-28,30,32H,8H2,1H3/t11-,13-,18+,20+,22+,23-,25-/m1/s1

InChI key: InChIKey=CYGIJEJDYJOUAN-JSGXPVSSSA-N

SMILES: O[C@@]12[C@@]3([C@@]([C@H]([C@@](C=C3[C@H]4OC=5C(C(=O)[C@@H]4O)=C(O)C=C(O)C5)(C1=O)[H])C6=CC(OC)=C(O)C=C6)(CO2)[H])[H]

Sinonimi:

• (+)-2,3alpha,3aalpha,7a-Tetrahydro-7aalpha-hydroxy-8-(4-hydroxy-3-methoxyphenyl)-4-(3alpha,5,7-trihydroxy-4-oxo-2beta-chromanyl)-3,6-methanobenzofuran-7(6alphaH)-one
• (3R,3aR,6R,7aR)-7a-hydroxy-8-(4-hydroxy-3-methoxyphenyl)-4-[(2R,3R)-3,5,7-trihydroxy-4-oxo-3,4-dihydro-2H-chromen-2-yl]-2,3,3a,7a-tetrahydro-3,6-methano-1-benzofuran-7(6H)-one
• (3R,3aR,6R,7aR,8R)-4-[(2R,3R)-3,4-Dihydro-3,5,7-trihydroxy-4-oxo-2H-1-benzopyran-2-yl]-2,3,3a,7a-tetrahydro-7a-hydroxy-8-(4-hydroxy-3-methoxyphenyl)-3,6-methanobenzofuran-7(6H)-one
• (3R,3aR,6R,7aR,8R)-7a-hydroxy-8-(4-hydroxy-3-methoxyphenyl)-4-[(2R)-3,5,7-trihydroxy-4-oxo-3,4-dihydro-2H-chromen-2-yl]-2,3,3a,7a-tetrahydro-3,6-methano-1-benzofuran-7(6H)-one
• 3,6-Methanobenzofuran-7(6H)-one, 4-(3,4-dihydro-3,5,7-trihydroxy-4-oxo-2H-1-benzopyran-2-yl)-2,3,3a,7a-tetrahydro-7a-hydroxy-8-(4-hydroxy-3-methoxyphenyl)-, [3R-[3α,3aβ,4(2R*,3R*),6α,7aβ,8R*]]-
• 3,6-Methanobenzofuran-7(6H)-one, 4-[(2R,3R)-3,4-dihydro-3,5,7-trihydroxy-4-oxo-2H-1-benzopyran-2-yl]-2,3,3a,7a-tetrahydro-7a-hydroxy-8-(4-hydroxy-3-methoxyphenyl)-, (3R,3aR,6R,7aR,8R)-
• 3,6-Methanobenzofuran-7(6αH)-one, 2,3α,3aα,7a-tetrahydro-7aα-hydroxy-8-(4-hydroxy-3-methoxyphenyl)-4-(3α,5,7-trihydroxy-4-oxo-2β-chromanyl)-, (+)-
• 7a-hydroxy-8-(4-hydroxy-3-methoxyphenyl)-4-(3,5,7-trihydroxy-4-oxo-3,4-dihydro-2H-chromen-2-yl)-2,3,3a,7a-tetrahydro-3,6-methano-1-benzofuran-7(6H)-one
• Silidianin [INN]
• Silidianina
• Silidianina [INN-Spanish]
• Silidianine
• Silidianine [INN-French]
• Silidianinum
• Silidianinum [INN-Latin]

Silydianin

CAS: 29782-68-1

Aromatic heterocyclic compounds with oxygen hetero-atom(s) only, nesoi

Formula: C₂₅H₂₂O₁₀

Colore e forma: Yellow Powder

Peso molecolare: 482.1213

Ref: 45-1612641

Silydianin

CAS: 29782-68-1

Formula: C₂₅H₂₂O₁₀

Purezza: 95%

Colore e forma: Solid

Peso molecolare: 482.4362

Ref: IN-DA00BE5C

(3R,3Ar,6R,7Ar,8R)-7A-Hydroxy-8-(4-Hydroxy-3-Methoxyphenyl)-4-((2R,3R)-3,5,7-Trihydroxy-4-Oxochroman-2-Yl)-3,3A,6,7A-Tetrahydro-3,6-Methanobenzofuran-7(2H)-One

CAS: 29782-68-1

(3R,3Ar,6R,7Ar,8R)-7A-Hydroxy-8-(4-Hydroxy-3-Methoxyphenyl)-4-((2R,3R)-3,5,7-Trihydroxy-4-Oxochroman-2-Yl)-3,3A,6,7A-Tetrahydro-3,6-Methanobenzofuran-7(2H)-One

Purezza: 95%

Peso molecolare: 482.44g/mol

Ref: 54-OR1023990

Silydianin

CAS: 29782-68-1

Silydianin

Purezza: ≥95%

Peso molecolare: 482.44g/mol

Ref: 54-BUP02913

Silydianin

CAS: 29782-68-1

Formula: C₂₅H₂₂O₁₀

Peso molecolare: 482.44

Ref: 7W-GY6531

Silydianin

CAS: 29782-68-1

Silydianin, an active constituent of Silybium marianum, has inhibitory effect on on the in vitro production and release of oxidative products. Silydianin has possible antiinflammatory activity, which regulates caspase-3 activation, affects cell membranes and acts as a free radical scavenger.

Formula: C₂₅H₂₂O₁₀

Purezza: 95%~99%

Peso molecolare: 482.441

Ref: BP-BP1307

Silydianin

CAS: 29782-68-1

Formula: C₂₅H₂₂O₁₀

Peso molecolare: 482.45

Ref: 4Z-S-398

Silydianin

CAS: 29782-68-1

Silydianin inhibits UGT, OATP1B1, OATP1B3 in HEK293 cells, and OATP2B1 in MDCK2 cells.

Formula: C₂₅H₂₂O₁₀

Purezza: 98.01% - 98.56%

Colore e forma: Solid

Peso molecolare: 482.44

Ref: TM-T3880

Silydianin

CAS: 29782-68-1

Oxygen-heterocyclic compound

Formula: C₂₅H₂₂O₁₀

Purezza: ≥ 95.0 % (HPLC)

Colore e forma: Powder

Peso molecolare: 482.44

Ref: 5G-89282

Silydianin

Prodotto controllato

CAS: 29782-68-1

Applications Silydianin is an active constituent of Silybium marianum and is known the exhibit anti-inflammatory activity which regulates caspase-3 activation which affects cell membranes and acts as a free radical scavenger.
References Zlelinska-Przyyjemska, M., et al.: Phytother. Res., 20, 115 (2006); Milan, M., et al.L Anal. Chimica. Acta., 486, 125 (2003); Liu, Y.Z., et al.: Chin. Herb. Med., 4, 237 (2012);

Formula: C₂₅H₂₂O₁₀

Colore e forma: Off-White

Peso molecolare: 482.44

Ref: TR-S465890

Silydianin

CAS: 29782-68-1

Silydianin is a flavonolignan compound, which is derived from the seeds of the milk thistle plant, Silybum marianum. Its primary mode of action involves antioxidant properties and inhibition of lipid peroxidation. Silydianin contributes to the stabilization of cell membranes, thereby preventing toxins from entering liver cells, and also stimulates the activity of ribosomal RNA, promoting liver cell regeneration.

Formula: C₂₅H₂₂O₁₀

Purezza: Min. 95.0 Area-%

Peso molecolare: 482.44 g/mol

Ref: 3D-FS42773