CAS 3031-95-6

SAICAR

Descrizione:

SAICAR, o N-succinil-5-aminoimidazolo-4-carbossamide ribonucleotide, è un composto chimico coinvolto nella via di biosintesi delle purine. È caratterizzato dal suo ruolo come intermediario nella sintesi dei nucleotidi purinici, specificamente nella conversione di amminoacidi e altri substrati in nucleotidi di adenina e guanina. Il composto presenta una struttura di ribonucleotide, che include uno zucchero ribosio, un gruppo carbossamide e un moiety succinilico. SAICAR si trova tipicamente nei sistemi biologici, in particolare negli organismi che utilizzano la via de novo per la sintesi dei nucleotidi. Il suo numero CAS, 3031-95-6, è un identificatore unico che facilita l'identificazione e lo studio di questo composto nella letteratura scientifica e nelle banche dati. Il composto è di interesse nella ricerca biochimica, in particolare negli studi relativi a vie metaboliche e funzioni enzimatiche. Comprendere le caratteristiche di SAICAR e il suo ruolo nel metabolismo può fornire informazioni sui processi cellulari e potenziali obiettivi terapeutici nelle malattie legate al metabolismo dei nucleotidi.

Formula: C₁₃H₁₉N₄O₁₂P

InChI: InChI=1S/C13H19N4O12P/c14-10-7(11(22)16-4(13(23)24)1-6(18)19)15-3-17(10)12-9(21)8(20)5(29-12)2-28-30(25,26)27/h3-5,8-9,12,20-21H,1-2,14H2,(H,16,22)(H,18,19)(H,23,24)(H2,25,26,27)/t4-,5+,8+,9+,12+/m0/s1

InChI key: InChIKey=NAQGHJTUZRHGAC-ZZZDFHIKSA-N

SMILES: NC=1N(C=NC1C(N[C@@H](CC(O)=O)C(O)=O)=O)[C@@H]2O[C@H](COP(=O)(O)O)[C@@H](O)[C@H]2O

Sinonimi:

• 3031-95-6
• 5-Amino-4-imidazole-N-succinocarboxamide ribonucleotide
• 5-Amino-N-(1,2-dicarboxyethyl)-1-ribofuranosylimidazole-4-carboxamide 5'-Phosphate
• <span class="text-smallcaps">L</smallcap>-Aspartic acid, N-[[5-amino-1-(5-O-phosphono-β-<smallcap>D</span>-ribofuranosyl)-1H-imidazol-4-yl]carbonyl]-
• Aspartic acid, N-[(5-amino-1-β-<span class="text-smallcaps">D</smallcap>-ribofuranosylimidazol-4-yl)carbonyl]-, 5′-(dihydrogen phosphate), <smallcap>L</span>-
• L-aspartic acid, N-[[5-amino-1-(5-O-phosphono-beta-D-ribofuranosyl)-1H-imidazol-4-yl]carbonyl]-
• N-(5-Amino-1-ribofuranosylimidazol-4-ylcarbonyl)aspartic acid 5′-phosphate
• N-[(5-Amino-1-ribofuranosylimidazol-4-yl)carbonyl]aspartic Acid 5'-Phosphate
• N-[5-Amino-1-(5'-phosphoribofuranosyl)-4-imidazolecarbonyl]aspartic Acid
• N-[[5-Amino-1-(5-O-phosphono-b-D-ribofuranosyl)-1H-imidazol-4-yl]carbonyl]-L-aspartic Acid
• N-[[5-Amino-1-(5-O-phosphono-β-<span class="text-smallcaps">D</smallcap>-ribofuranosyl)-1H-imidazol-4-yl]carbonyl]-<smallcap>L</span>-aspartic acid
• Saicar
• Succino-AICAR
• L-Aspartic acid, N-[[5-amino-1-(5-O-phosphono-β-D-ribofuranosyl)-1H-imidazol-4-yl]carbonyl]-
• Aspartic acid, N-[(5-amino-1-β-D-ribofuranosylimidazol-4-yl)carbonyl]-, 5′-(dihydrogen phosphate), L-

N-[[5-Amino-1-(5-O-phosphono-b-D-ribofuranosyl)-1H-imidazoL-4-yl]carbonyl]-L-aspartic acid

CAS: 3031-95-6

Formula: C₁₃H₁₉N₄O₁₂P

Colore e forma: Solid

Peso molecolare: 454.2833

Ref: IN-DA002ZMH

SAICAR

CAS: 3031-95-6

SAICAR is an intermediate of de novo purine nucleotide biosynthesis, activates pyruvate kinase isoform M2 (PKM2) in an isozyme-selective manner (EC50: 0.3 mM).

Formula: C₁₃H₁₉N₄O₁₂P

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 454.28

Ref: TM-T16837

N-Succinyl-5-aminoimidazole-4-carboxamide Ribose 5’-Phosphate

CAS: 3031-95-6

Applications N-Succinyl-5-aminoimidazole-4-carboxamide Ribose 5’-Phosphate is a metabolite of Purine. Since adenosine is a potent inhibitor of neuronal function, depressing the release of several excitatory transmitters and causing direct hyperpolarization of neurons, it was possible that the symptoms seen in adenylosuccinate lyase (ASase) deficient patients could reflect an interference of succinylpurines with neurotransmission.
References Gollub, E.G., et al.: J. Bacteriol., 78, 320 (1959), Srivastava, P.C., et al.: J. Med. Chem., 17, 1207 (1974),

Formula: C₁₃H₁₉N₄O₁₂P

Colore e forma: Neat

Peso molecolare: 454.28

Ref: TR-S688795

N-Succinyl-5-aminoimidazole-4-carboxamide ribose 5'-phosphate

CAS: 3031-95-6

N-Succinyl-5-aminoimidazole-4-carboxamide ribose 5'-phosphate is a synthetase that is involved in the biosynthesis of purines and pyrimidines. It catalyzes the ATP-dependent formation of N-succinyl5'-aminoimidazole-4-carboxamide ribose 5'-phosphate from succinyl CoA and aspartic acid. This enzyme has been studied in wild type strains of bacteria, such as Escherichia coli, but not in humans or other organisms. N-Succinyl5'-aminoimidazole-4-carboxamide ribose 5'-phosphate has been shown to be an inhibitor of antimicrobial agents such as penicillin G, erythromycin, and tetracycline. The mechanism for this inhibition is unclear, but it may involve hydrogen bonding interactions or structural changes that prevent binding

Formula: C₁₃H₁₉N₄O₁₂P

Purezza: Min. 95 Area-%

Colore e forma: White Off-White Powder

Peso molecolare: 454.28 g/mol

Ref: 3D-NS166064