CAS 3049076-98-1

YX-02-030

CAS: 3049076-98-1

YX-02-030M is a PROTACMDM2 degrader. It inhibits the binding of MDM2 to p53 and VHL to HIF1α, with IC50 values of 63 nM and 1.35 μM, respectively. YX-02-030M binds to MDM2 and recruits the VHL E3 ubiquitin ligase to initiate MDM2 degradation, effectively killing p53 mutant or deficient triple-negative breast cancer (TNBC) cells.

Formula: C₆₆H₈₅Cl₂N₉O₁₀S

Peso molecolare: 1267.41

Ref: TM-T208219