CAS 30562-34-6

Geldanamicina

Descrizione:

Geldanamicina è un antibiotico ansamicina benzochinone noto principalmente per la sua capacità di inibire la proteina da shock termico 90 (Hsp90), un chaperone molecolare coinvolto nella stabilizzazione e nella funzione di numerose proteine client, comprese molte coinvolte nella progressione del cancro. La sua struttura chimica presenta un nucleo biciclico complesso con un moiety di chinone, contribuendo alla sua attività biologica. Geldanamicina mostra una gamma di effetti farmacologici, in particolare nella terapia del cancro, poiché può indurre apoptosi nelle cellule tumorali interrompendo la funzione delle proteine oncogeniche. Inoltre, ha mostrato potenziale nel mirare a varie vie di segnalazione, rendendolo un argomento di interesse nello sviluppo di farmaci. Tuttavia, il suo uso clinico è limitato da problemi di tossicità e solubilità, portando allo sviluppo di analoghi con proprietà migliorate. Come prodotto naturale derivato dal batterio *Streptomyces hygroscopicus*, Geldanamicina serve come uno strumento prezioso sia in contesti di ricerca che terapeutici, in particolare nello studio della biologia del cancro e nello sviluppo di inibitori di Hsp90.

Formula: C₂₉H₄₀N₂O₉

InChI: InChI=1/C29H40N2O9/c1-15-11-19-25(34)20(14-21(32)27(19)39-7)31-28(35)16(2)9-8-10-22(37-5)26(40-29(30)36)18(4)13-17(3)24(33)23(12-15)38-6/h8-10,13-15,17,22-24,26,33H,11-12H2,1-7H3,(H2,30,36)(H,31,35)/b10-8-,16-9+,18-13+/t15-,17+,22+,23+,24-,26+/m1/s1

InChI key: InChIKey=QTQAWLPCGQOSGP-KSRBKZBZSA-N

SMILES: O(C)C1=C2C(=O)C(=CC1=O)NC(=O)\C(\C)=C\C=C/[C@H](OC)[C@@H](OC(N)=O)\C(\C)=C\[C@H](C)[C@@H](O)[C@@H](OC)C[C@H](C)C2

Sinonimi:

• (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl carbamate
• (8S,9S,12S,13R,14S,16R)-13-Hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl carbamate
• 2-Azabicyclo[16.3.1]docosa-4,6,10,18,21-pentaene-3,20,22-trione, 9,13-dihydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-, 9-carbamate
• 2-Azabicyclo[16.3.1]docosa-4,6,10,18,21-pentaene-3,20,22-trione, 9-[(aminocarbonyl)oxy]-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-, [8S-(4E,6Z,8R*,9R*,10E,12R*,13S*,14R*,16S*)]-
• 2-Azabicyclo[16.3.1]docosane, geldanamycin deriv.
• Brn 1633093
• NSC 212518
• Nsc 122750
• U-29135
• [8S-(4E,6Z,8R*,9R*,10E,12R*,13S*,14R*,16S*)]-9-[(Aminocarbonyl)oxy]-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-2-azabicyclo[16.3.1]docosa-4,6,10,18,21-pentaene-3,20,22-trione
• Geldanamycin
• [(4Z,6E,8R,9R,10Z,12R,13R,14R,16R)-13-Hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-4,6,10,18,21-pentaen-9-yl] carbamate
• GELDANAMYCIN, STREPTOMYCES HYGROSCOPICUS
• GELDANAMYCIN, 99+%
• [(8Z,12Z,14Z)-6-hydroxy-5,11,21-trimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate
• 9,13-Dihydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-2-azabicyclo[16.3.1]docosa-4,6,10,18,21-pentaene-3,20,22-trione 9-Carbamate
• (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-9-[(Aminocarbonyl)oxy]-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-2-azabicyclo[16.3.1]docosa-4,6,10,18,21(1)-pentene-3,20,22-trione
• CP-122634
• nsc122750
• GA
• GELDANAMYCIN (GDM)
• 9,13-DIHYDROXY-8,14,19-TRIMETHOXY-4,10,12,16-TETRAMETHYL-2-AZABICYCLO[16.3.1]DOCOSA-4,6,10,18,21-PENTAENE-3,20,22-TRIONE, 9-CARBAMATE
• GELDANAMYCIN FROM STREPTOMYCES*HYGROSCOP ICUS
• [(3R,5R,6S,7R,8E,10R,11R,12Z,14E)-6-Hydroxy-5,11,21-trimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate
• Streptomyces hygroscopicus

Geldanamycin

CAS: 30562-34-6

Formula: C₂₉H₄₀N₂O₉

Purezza: >95.0%(qNMR)

Colore e forma: White to Yellow to Orange powder to crystal

Peso molecolare: 560.64

Ref: 3B-G0334

Geldanamycin, 98+%

CAS: 30562-34-6

Benzoquinoid antibiotic that inhibits pp60src tyrosine kinase

Formula: C₂₉H₄₀N₂O₉

Purezza: 98+%

Colore e forma: Yellow, Powder or crystals or crystalline powder

Peso molecolare: 560.64

Ref: 02-J63397

Geldanamycin

CAS: 30562-34-6

Formula: C₂₉H₄₀N₂O₉

Purezza: 100.0%

Colore e forma: Orange amorphous solid

Peso molecolare: 560.0

Ref: 8R-PB0001

[8S-(4E,6Z,8R*,9R*,10E,12R*,13S*,14R*,16S*)]-9-[(Aminocarbonyl)oxy]-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-2-azabicyclo[16.3.1]docosa-4,6,10,18,21-pentaene-3,20,22-trione

CAS: 30562-34-6

Formula: C₂₉H₄₀N₂O₉

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 560.6359

Ref: IN-DA0038U7

Geldanamycin

CAS: 30562-34-6

Geldanamycin

Purezza: ≥95%

Peso molecolare: 560.64g/mol

Ref: 54-BUP06940

Geldanamycin

CAS: 30562-34-6

Formula: C₂₉H₄₀N₂O₉

Purezza: ≥ 98.0%

Colore e forma: Yellow to orange powder

Peso molecolare: 560.64

Ref: 7W-GA6838

Geldanamycin

CAS: 30562-34-6

Formula: C₂₉H₄₀N₂O₉

Peso molecolare: 560.64

Ref: 4Z-G-165001

Geldanamycin, Streptomyces hygroscopicus

CAS: 30562-34-6

Formula: C₂₉H₄₀N₂O₉

Purezza: >95%

Colore e forma: Solid

Peso molecolare: 560.644

Ref: 10-M01803

Geldanamycin

CAS: 30562-34-6

Geldanamycin, an HSP90 inhibitor (Kd: 1.2 μM), specifically disrupts glucocorticoid receptor (GR)/HSP association.

Formula: C₂₉H₄₀N₂O₉

Purezza: 97.59% - 99.27%

Colore e forma: Yellow To Orange Powder

Peso molecolare: 560.64

Ref: TM-T6343

Geldanamycin

CAS: 30562-34-6

Geldanamycin

Formula: C₂₉H₄₀N₂O₉

Purezza: By hplc: 99.66% (Typical Value in Batch COA)

Colore e forma: yellow powder

Peso molecolare: 560.64g/mol

Ref: 54-BIG2461

Geldanamycin

Prodotto controllato

CAS: 30562-34-6

Applications Geldanamycin is a potent antitumor antibiotic active at nanomolar concentration against 60 cell lines.It binds specifically to the heat shock protein Hsp90 and to its endoplasmic reticulum homologue GP96, and thus interferes with conformational maturation of proteins and the cellular stress response. In addition, it is a potent inhibitor of the nuclear hormone receptor family.
References Supko, J.G., et al.: Cancer Chemother. Pharmacol., 36, 305 (1995), Chavany, C., et al.: J. Biol. Chem., 271, 4974 (1996), Schneider, C., et al.: Proc. Natl. Acad. Sci., 93, 14536 (1996), Whitesell, L., et al.: Mol. Endocrinol., 10, 705 (1996), Stebbins, C.E., et al.: Cell, 89, 239 (1997),

Formula: C₂₉H₄₀N₂O₉

Colore e forma: Neat

Peso molecolare: 560.64

Ref: TR-G304500

Geldanamycin

CAS: 30562-34-6

Inhibits chaperone protein HSP90; anti-proliferative; antineoplastic

Formula: C₂₉H₄₀N₂O₉

Purezza: Min. 95%

Colore e forma: Yellow Powder

Peso molecolare: 560.64 g/mol

Ref: 3D-AG23651

Geldanamycin (GLD) ex. Streptomyces Hygroscopicus, 98%

CAS: 30562-34-6

Formula: C₂₉H₄₀N₂O₉

Purezza: min. 98%

Colore e forma: White to Yellow to Orange, Powder or Crystals, Clear

Peso molecolare: 560.64

Ref: SR-23813

Geldanamycin-FITC

Prodotto controllato

CAS: 30562-34-6

Formula: C₅₅H₆₃N₅O₁₃S

Colore e forma: Neat

Peso molecolare: 1034.18

Ref: TR-G368230