CAS 30685-43-9

Metildigossina

Descrizione:

Metildigossina è un glicoside cardiaco, una classe di composti noti per la loro capacità di aumentare la forza delle contrazioni cardiache e regolare il ritmo cardiaco. È derivato dalla digossina, che si ottiene dalla pianta digitale (Digitalis purpurea). Metildigossina presenta un meccanismo d'azione simile a quello di altri glicosidi cardiaci, principalmente inibendo l'enzima Na+/K+ ATPasi, portando a un aumento dei livelli di calcio intracellulare e a una maggiore contrattilità cardiaca. Questo composto è spesso utilizzato nel trattamento dell'insufficienza cardiaca e di alcune aritmie. In termini di struttura chimica, Metildigossina presenta un nucleo steroideo con specifiche moieties di zucchero che contribuiscono alle sue proprietà farmacologiche. Il composto viene tipicamente somministrato in modo controllato a causa del suo stretto indice terapeutico, il che significa che la differenza tra una dose efficace e una dose tossica è piccola. Come per altri glicosidi cardiaci, il monitoraggio dei livelli sierici e della risposta del paziente è cruciale per garantire sicurezza ed efficacia durante il trattamento.

Formula: C₄₂H₆₆O₁₄

InChI: InChI=1/C42H66O14/c1-20-37(49-6)28(43)17-35(50-20)55-39-22(3)52-36(19-30(39)45)56-38-21(2)51-34(18-29(38)44)53-24-11-13-40(4)23(15-24)7-8-25-27(40)16-32(46)41(5)26(12-14-42(25,41)48)31-9-10-33(47)54-31/h9,20-30,32,34-39,43-46,48H,7-8,10-19H2,1-6H3/t20?,21?,22?,23-,24+,25-,26-,27+,28?,29?,30?,32-,34?,35?,36?,37?,38?,39?,40+,41+,42+/m1/s1

InChI key: InChIKey=IYJMSDVSVHDVGT-PEQKVOOWSA-N

SMILES: O[C@@]12[C@@](C)([C@H](CC1)C3=CC(=O)OC3)[C@H](O)C[C@]4([C@]2(CC[C@]5([C@]4(C)CC[C@H](O[C@H]6C[C@H](O)[C@H](O[C@H]7C[C@H](O)[C@H](O[C@H]8C[C@H](O)[C@H](OC)[C@@H](C)O8)[C@@H](C)O7)[C@@H](C)O6)C5)[H])[H])[H]

Sinonimi:

• (3beta,5beta,12beta,17xi)-3-{[2,6-dideoxy-4-O-methyl-beta-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl]oxy}-12,14-dihydroxycard-20(22)-enolide
• (3β,5β,12β)-3-[(O-2,6-Dideoxy-4-O-methyl-β-<span class="text-smallcaps">D</smallcap>-ribo-hexopyranosyl-(1→4)-O-2,6-dideoxy-β-<smallcap>D</smallcap>-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-<smallcap>D</span>-ribo-hexopyranosyl)oxy]-12,14-dihydroxycard-20(22)-enolide
• 4′′′-Methyldigoxin
• 4′′′-O-Methyldigoxin
• 4′′′-β-Methyldigoxin
• Card-20(22)-enolide, 3-[(O-2,6-dideoxy-4-O-methyl-β-<span class="text-smallcaps">D</smallcap>-ribo-hexopyranosyl-(1→4)-O-2,6-dideoxy-β-<smallcap>D</smallcap>-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-<smallcap>D</span>-ribo-hexopyranosyl)oxy]-12,14-dihydroxy-, (3β,5β,12β)-
• Digoxin, 4′′′-O-methyl-
• Lanirapid
• Lanitop
• Medigoxin
• Methyldigoxin
• beta-Methyldigoxin
• β-Methyldigoxin
• (3β,5β,12β)-3-[(O-2,6-Dideoxy-4-O-methyl-β-D-ribo-hexopyranosyl-(1→4)-O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-D-ribo-hexopyranosyl)oxy]-12,14-dihydroxycard-20(22)-enolide
• Card-20(22)-enolide, 3-[(O-2,6-dideoxy-4-O-methyl-β-D-ribo-hexopyranosyl-(1→4)-O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-D-ribo-hexopyranosyl)oxy]-12,14-dihydroxy-, (3β,5β,12β)-
• β-Methyl Digoxin
• -β-Methyl Digoxin
• Metildigoxin RS
• Digoxin, 4'''-O-methyl- (8CI)
• Metildigoxin
• Metildigoxin USP/EP/BP
• 3β-[[4-O-[4-O-(4-O-Methyl-2,6-dideoxy-β-D-ribo-hexopyranosyl)-2,6-dideoxy-β-D-ribo-hexopyranosyl]-2,6-dideoxy-β-D-ribo-hexopyranosyl]oxy]-12β,14-dihydroxy-5β,14β-card-20(22)-enolide

Metildigoxin

CAS: 30685-43-9

Formula: C₄₂H₆₆O₁₄

Colore e forma: White To Off-White Solid

Peso molecolare: 794.98

Ref: 4Z-M-721

Metildigoxin RS

CAS: 30685-43-9

Colore e forma: White To Light Yellowish White Solid Crystalline Powder

Ref: 2K-1162000021

β-Methyl Digoxin

CAS: 30685-43-9

Applications Cardiotonic. Obtained by the O-methylation of Digoxin.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Hunter, J., et al.: J. Biol. Chem., 268, 14991 (1993), Greiner, B., et al.: J. Clin. Invest., 104, 147 (1999), Jun, A., et al.: J. Pharm.Pharm. Sci., 4, 263 (2001), Sugiyama, D., et al.: Drug Metab. Dispos., 30, 220 (2002),

Formula: C₄₂H₆₆O₁₄

Colore e forma: Neat

Peso molecolare: 794.97

Ref: TR-M301850

β-Methyldigoxin

CAS: 30685-43-9

B-methyldigoxin is a drug that can be used to study the role of P-gp in drug transport. It has been shown to inhibit P-gp function and thus increase the amount of digoxin transported into the cells. This drug also inhibits cyclooxygenase, which is responsible for the production of prostaglandins, leading to anti-inflammatory effects. B-methyldigoxin has been shown to lower systolic pressure in rats with bowel disease and has been found to have cardiac effects in rats with congestive heart failure. The clinical relevance of this drug is not known, but it may be useful for treating geriatric patients or those with autoimmune diseases, as well as those who have had a cardiac event or are at risk for congestive heart failure.

Formula: C₄₂H₆₆O₁₄

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 794.97 g/mol

Ref: 3D-FM09709

β-Methyl Digoxin

CAS: 30685-43-9

Formula: C₄₂H₆₆O₁₄

Peso molecolare: 794.97

Ref: ST-EA-CP-D1200012