CAS 30868-30-5

Pirazofurina

Descrizione:

Pirazofurina è un analogo di nucleoside sintetico con notevoli proprietà antivirali, che colpisce principalmente i virus a RNA. È caratterizzato dalla sua struttura ad anello di pirazolo, essenziale per la sua attività biologica. Il composto mostra un meccanismo d'azione che implica l'inibizione della sintesi di RNA virale, rendendolo un potenziale agente terapeutico contro varie infezioni virali. Pirazofurina è solubile in acqua e presenta una stabilità moderata in condizioni fisiologiche. Il suo profilo farmacologico include efficacia antivirale, sebbene il suo utilizzo possa essere limitato da fattori come tossicità e sviluppo di resistenza nelle popolazioni virali. La ricerca ha indicato che potrebbe anche possedere effetti immunomodulatori, contribuendo alla sua attività antivirale complessiva. Come per molti analoghi di nucleosidi, è fondamentale considerare attentamente il dosaggio e la somministrazione per massimizzare i benefici terapeutici riducendo al minimo gli effetti avversi. Studi in corso continuano a esplorare le sue potenziali applicazioni nel trattamento delle malattie virali, in particolare nel contesto delle minacce virali emergenti.

Formula: C₉H₁₃N₃O₆

InChI: InChI=1/C9H13N3O6/c10-9(17)4-6(15)3(11-12-4)8-7(16)5(14)2(1-13)18-8/h2,5,7-8,13-16H,1H2,(H2,10,17)(H,11,12)/t2-,5-,7-,8+/m1/s1

InChI key: InChIKey=XESARGFCSKSFID-FLLFQEBCSA-N

SMILES: O[C@H]1[C@@H](O[C@H](CO)[C@H]1O)C=2C(O)=C(C(N)=O)NN2

Sinonimi:

• (1S)-1,4-anhydro-1-(5-carbamoyl-4-hydroxy-1H-pyrazol-3-yl)-D-ribitol
• (1S)-1-{(5E)-5-[amino(hydroxy)methylidene]-4-oxo-4,5-dihydro-1H-pyrazol-3-yl}-1,4-anhydro-D-ribitol
• (1S)-1-{(5Z)-5-[amino(hydroxy)methylidene]-4-oxo-4,5-dihydro-1H-pyrazol-3-yl}-1,4-anhydro-D-ribitol
• 1-{(5E)-5-[amino(hydroxy)methylidene]-4-oxo-4,5-dihydro-1H-pyrazol-3-yl}-1,4-anhydropentitol
• 1H-Pyrazole-5-carboxamide, 4-hydroxy-3-beta-D-ribofuranosyl-
• 1H-Pyrazole-5-carboxamide, 4-hydroxy-3-β-<span class="text-smallcaps">D</span>-ribofuranosyl-
• 4-Hydroxy-3-beta-<span class="text-smallcaps">D</span>-ribofuranosylpyrazole-5-carboxamide
• 4-Hydroxy-3-beta-D-ribofuranosylpyrazole-5-carboxamide
• 4-Hydroxy-3-β-<span class="text-smallcaps">D</span>-ribofuranosyl-1H-pyrazole-5-carboxamide
• Antibiotic A 23813
• NSC 143095
• Pirazofurin
• Przf
• Pyrazole-3-carboxamide, 4-hydroxy-5-beta-L-ribofuranosyl-
• Pyrazomycin
• Pyrozofurin
• beta-Pyrazomycin
• β-Pyrazofurin
• β-Pyrazomycin
• 1H-Pyrazole-5-carboxamide, 4-hydroxy-3-β-D-ribofuranosyl-
• Pyrazofurin
• 4-Hydroxy-3-β-D-ribofuranosyl-1H-pyrazole-5-carboxamide
• 3-beta-d-ribofuranosyl-4-hydroxypyrazole-5-carboxamide
• compound47599
• nsc143095
• 47599
• 4-HYDROXY-3-BETA-D-RIBOFURANOSYL-1H-PYRAZOLE-5-CARBOXAMIDE MONOHYDRATE
• 4-hydroxy-3-beta-d-ribofuranosyl-1h-pyrazole-5-carboxamide
• A-23813
• 4-hydroxy-3-beta-d-ribofuranosyl-1h-pyrazole-5-carboxamid
• PYRAZOFURIN MONOHYDRATE

4-HYDROXY-3-β-D-RIBOFURANOSYL-1H-PYRAZOLE-5-CARBOXAMIDE MONOHYDRATE

CAS: 30868-30-5

Formula: C₉H₁₃N₃O₆

Purezza: 97%

Colore e forma: Solid

Peso molecolare: 259.2160

Ref: IN-DA00BE0N

3-((2S,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-hydroxy-1H-pyrazole-5-carboxamide

CAS: 30868-30-5

3-((2S,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-hydroxy-1H-pyrazole-5-carboxamide

Purezza: 97%

Peso molecolare: 259.22g/mol

Ref: 54-OR1074824

Pyrazofurin

CAS: 30868-30-5

Pyrazofurin is an antiviral drug that inhibits viral DNA synthesis by inhibiting the enzyme ribonucleotide reductase. It has been shown to be effective for bowel disease in mice and murine hepatoma cells. Pyrazofurin binds to the pyrazole ring of the enzyme, thereby inhibiting its activity and preventing the formation of uridine triphosphate (UTP) from uridine monophosphate (UMP). This compound also has anti-cancer activities, which may be due to its ability to inhibit cell growth by targeting enzymes that are expressed at high levels in cancer tissues. Pyrazofurin is used as a biological sample to measure enzyme activities such as dextran sulfate and other substances that can be detected through colorimetric or fluorometric assays.

Formula: C₁₁H₁₄F₃N₃O₈

Purezza: Min. 95%

Peso molecolare: 373.24 g/mol

Ref: 3D-FBA86830

Pyrazofurin

CAS: 30868-30-5

Pyrazofurin, a pyrimidine analogue, blocks cell growth and DNA synthesis by targeting UMP synthase & orotate-phosphoribosyltransferase (IC50: 0.06-0.37 μM).

Formula: C₉H₁₃N₃O₆

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 259.22

Ref: TM-T16690