CAS 3094-09-5

Doxifluridina

Descrizione:

Doxifluridina, con il numero CAS 3094-09-5, è un analogo di pirimidina fluorurata utilizzato principalmente nella terapia del cancro. È strutturalmente correlato al nucleoside timidina e funziona come un antimetabolita, inibendo la sintesi del DNA interferendo con l'azione della timidilato sintasi. Questo meccanismo lo rende particolarmente efficace contro le cellule tumorali a rapida divisione. Doxifluridina viene tipicamente somministrato nella sua forma di profarmaco, che viene convertita nel suo metabolita attivo all'interno del corpo. Il composto presenta un profilo di tossicità relativamente basso rispetto ad altri agenti chemioterapici, rendendolo un'opzione preziosa nelle terapie combinate per varie malignità. In termini di proprietà fisiche, Doxifluridina è una polvere cristallina bianca o bianco sporco, solubile in acqua, e ha un peso molecolare moderato. La sua farmacocinetica coinvolge processi di assorbimento, distribuzione, metabolismo ed escrezione che sono cruciali per la sua efficacia terapeutica. In generale, Doxifluridina rappresenta uno strumento importante nell'arsenale della farmacoterapia oncologica, particolarmente per i tumori gastrointestinali.

Formula: C₉H₁₁FN₂O₅

InChI: InChI=1/C9H11FN2O5/c1-3-5(13)6(14)8(17-3)12-2-4(10)7(15)11-9(12)16/h2-3,5-6,8,13-14H,1H3,(H,11,15,16)/t3-,5-,6?,8?/m1/s1

InChI key: InChIKey=ZWAOHEXOSAUJHY-ZIYNGMLESA-N

SMILES: O[C@H]1[C@@H](O[C@H](C)[C@H]1O)N2C(=O)NC(=O)C(F)=C2

Sinonimi:

• (2Xi)-5'-Deoxy-5-Fluorouridine
• 5'-Deoxy-5-fluorouridine
• 5'-Dfur
• 5-Fluoro-5'-deoxyuridine
• 5-Fluorodesoxyuridine
• 5′-dFUrd
• Flutron
• Fulturon
• Furtulon
• Ro 21-9738
• Uridine, 5′-deoxy-5-fluoro-
• Doxifluridine
• 5Urd, 5-Fluoro-5deoxyuridine
• Doxifluridine (furtulon)
• 5'-Deoxy-fluorouridine(DFUR)/Doxifluridine
• (+)-5-FLUORO-5'-DEOXYURIDINE 97%
• 5'-DEOXYFLUOROURIDINE
• 5-FLURO-5’-DEOXYURIDINE
• DOXIFLUIRDINE
• 5Deoxy-5-fluorouridine, 5DFUR, 5dFUrd, Ro-21-9738
• Doxifluidine
• DOXIFLURIDINE(SUBJECTTOPATENTFREE)

5'-Deoxy-5-fluorouridine

CAS: 3094-09-5

Formula: C₉H₁₁FN₂O₅

Purezza: >98.0%(T)(HPLC)

Colore e forma: White to Almost white powder to crystal

Peso molecolare: 246.19

Ref: 3B-D3579

Capecitabine EP Impurity B

CAS: 3094-09-5

Formula: C₉H₁₁FN₂O₅

Peso molecolare: 246.19

Ref: ST-EA-CP-C52002

CAPECITABINE IMPURITY B CRS

CAS: 3094-09-5

CAPECITABINE IMPURITY B CRS

Formula: C₁₅H₂₂FN₃O₆

Peso molecolare: 359.3501

Ref: 41-Y0001644

Capecitabine Related Compound B (5'-deoxy-5-fluorouridine)

CAS: 3094-09-5

Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoi

Formula: C₉H₁₁FN₂O₅

Colore e forma: White Powder

Peso molecolare: 246.0652

Ref: 45-1090728

Uridine, 5'-deoxy-5-fluoro-

CAS: 3094-09-5

Formula: C₉H₁₁FN₂O₅

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 246.1924

Ref: IN-DA0031Q7

Doxifluridine

CAS: 3094-09-5

Doxifluridine (AMC 0101) is a fluoropyrimidine derivative and oral prodrug of the antineoplastic agent 5-fluorouracil (5-FU) with antitumor activity.

Formula: C₉H₁₁FN₂O₅

Purezza: 99.47% - 99.86%

Colore e forma: White Solid

Peso molecolare: 246.19

Ref: TM-T1600

5'-DFUR-13C5 (5'-Deoxy-5-fluorouridine, Doxifluridine-13C5)

CAS: 3094-09-5

Formula: C₉H₁₁FN₂O₅

Peso molecolare: 251.22

Ref: 4Z-C-355

Capecitabine EP Impurity B (5'-DFUR, Doxifluridine)

CAS: 3094-09-5

Formula: C₉H₁₁FN₂O₅

Colore e forma: White To Off-White Solid

Peso molecolare: 246.19

Ref: 4Z-C-354

Doxifluridine

CAS: 3094-09-5

Doxifluridine

Purezza: ≥98%

Peso molecolare: 246.19g/mol

Ref: 54-BUP19641

1-(5-Deoxy-β-D-ribofuranosyl)-5-fluoropyrimidine-2,4(1H,3H)-dione (5'-Deoxy-5-fluorouridine)

CAS: 3094-09-5

Colore e forma: Neat

Ref: 86-MM0992.06

(+)-5-Fluoro-5'-deoxyuridine

CAS: 3094-09-5

(+)-5-Fluoro-5'-deoxyuridine

Formula: C₉H₁₁FN₂O₅

Purezza: 98%

Colore e forma: white solid

Peso molecolare: 246.19g/mol

Ref: 54-PC5775

5-Fluoro-5''-deoxyuridine

CAS: 3094-09-5

Formula: C₉H₁₁FN₂O₅

Peso molecolare: 246.19

Ref: 7W-GP7931

5’-Deoxyfluorouridine-13C,15N2

Prodotto controllato

CAS: 3094-09-5

Applications 5’-Deoxyfluorouridine-13C,15N2 is a compound useful in organic synthesis.

Formula: C₈CH₁₁FN₂O₅

Colore e forma: Neat

Peso molecolare: 249.17

Ref: TR-D235727

5’-Deoxy-5-fluorouridine

Prodotto controllato

CAS: 3094-09-5

Impurity USP Capecitabine Related Compound B
Applications 5’-Deoxy-5-fluorouridine is a metabolite of the chemotherapeutic agent Capecitabine (C175650). 5’-Deoxy-5-fluorouridine is an antitumor agent efficient in tumors, cell lines or in fibroblasts tranformed by H-ras or trk oncogenes.
References Ingle, J., et al.: Cancer, 67, 886 (1991); Harvey, J., et al.: J. Clin. Oncol., 17, 1474 (1999); Asai-Sato, M., et al.: Int. J. Cancer, 115, 539 (2005); Rastelli, F., et al.: Tumori, 94, 370 (2008);

Formula: C₉H₁₁FN₂O₅

Colore e forma: Neat

Peso molecolare: 246.19

Ref: TR-D235725

Doxifluridine

Prodotto controllato

CAS: 3094-09-5

Impurity USP Capecitabine Related Compound B / Capecitabine EP Impurity B
Applications A prodrug of 5-Flurouridine. A fluorinated pyrimidine nucleoside with cytostatic activity.
References De Cesare, M., et al.: Cancer Res., 49, 5969 (1994), Di Bartolomeo, M., et al.: Tumori, 81, 147 (1995)

Formula: C₉H₁₁FN₂O₅

Colore e forma: Neat

Peso molecolare: 246.19

Ref: TR-D556750

5'-Deoxy-5-fluorouridine

CAS: 3094-09-5

5'-Deoxy-5-fluorouridine (5FU) is a nucleoside that is used in the treatment of cancer. It is an antimetabolite that inhibits the synthesis of DNA, RNA, and proteins by reversibly inhibiting ribonucleotide reductase. 5FU also inhibits epidermal growth factor receptor (EGFR), which leads to apoptosis in cancerous cells. The concentration–time curve for 5FU has been determined using tissue culture and hl-60 cells as biological samples. This drug has been shown to be effective against metastatic colorectal cancer when administered with other chemotherapeutic drugs.

Formula: C₉H₁₁FN₂O₅

Purezza: Min. 98 Area-%

Colore e forma: White Powder

Peso molecolare: 246.2 g/mol

Ref: 3D-ND02968

Doxifluridine

CAS: 3094-09-5

Purezza: 98%

Peso molecolare: 246.19

Ref: 10-F787567