CAS 31373-65-6

Hippuril-L-istidil-L-leucina

Descrizione:

Hippuril-L-istidil-L-leucina, identificato dal suo numero CAS 31373-65-6, è un derivato di dipeptide che consiste negli aminoacidi istidina e leucina legati da un legame peptidico a un gruppo di acido ipurico. Questo composto presenta caratteristiche tipiche dei peptidi, inclusa la capacità di partecipare a varie reazioni e interazioni biochimiche grazie ai suoi gruppi funzionali. È probabile che sia solubile in solventi polari, come l'acqua, grazie alla presenza di gruppi amminici e carbossilici che possono partecipare a legami idrogeno. La presenza di istidina contribuisce alla sua potenziale capacità tampone, mentre la leucina può migliorare le interazioni idrofobiche. Hippuril-L-istidil-L-leucina può avere applicazioni nella ricerca biochimica, in particolare in studi relativi alla sintesi di peptidi, interazioni proteiche e vie metaboliche. La sua stabilità e reattività possono essere influenzate da fattori ambientali come pH e temperatura, che sono critici per il suo comportamento nei sistemi biologici. In generale, questo composto rappresenta un'area affascinante di studio all'interno della chimica dei peptidi e della biochimica.

Formula: C₂₁H₂₇N₅O₅

InChI: InChI=1S/C21H27N5O5/c1-13(2)8-17(21(30)31)26-20(29)16(9-15-10-22-12-24-15)25-18(27)11-23-19(28)14-6-4-3-5-7-14/h3-7,10,12-13,16-17H,8-9,11H2,1-2H3,(H,22,24)(H,23,28)(H,25,27)(H,26,29)(H,30,31)/t16-,17-/m0/s1

InChI key: InChIKey=AAXWBCKQYLBQKY-IRXDYDNUSA-N

SMILES: [C@H](CC1=CN=CN1)(C(N[C@@H](CC(C)C)C(O)=O)=O)NC(CNC(=O)C2=CC=CC=C2)=O

Sinonimi:

• <span class="text-smallcaps">L</smallcap>-Leucine, N-[N-(N-benzoylglycyl)-<smallcap>L</span>-histidyl]-
• <span class="text-smallcaps">L</smallcap>-Leucine, N-benzoylglycyl-<smallcap>L</span>-histidyl-
• Hippuryl-<span class="text-smallcaps">L</smallcap>-histidyl-<smallcap>L</span>-leucine
• Hippuryl-His-Leu
• Leucine, N-(N-hippuroyl-<span class="text-smallcaps">L</smallcap>-histidyl)-, <smallcap>L</span>-
• N-Benzoylglycyl-<span class="text-smallcaps">L</smallcap>-histidyl-<smallcap>L</span>-leucine
• N-Benzoylglycyl-L-histidyl-L-leucine
• Hippuryl-L-histidyl-L-leucine
• L-Leucine, N-benzoylglycyl-L-histidyl-
• L-Leucine, N-[N-(N-benzoylglycyl)-L-histidyl]-
• Leucine, N-(N-hippuroyl-L-histidyl)-, L-

Hippuryl-His-Leu-OH

CAS: 31373-65-6

Substrate for a spectrophotometric assay of angiotensin I-converting enzyme. ACE cleavage of Hip-His-Leu yields hippuric acid and His-Leu (G-2310), which can be quantified by generating a fluorescent adduct with o-phthalaldehyde. Schwager et al. developed a high-throughput fluorometric assay for ACE employing Hip-His-Leu.

Formula: C₂₁H₂₇N₅O₅

Purezza: ≥ 99%

Colore e forma: White Lyophilisate

Peso molecolare: 429.48

Ref: 01-4002147

Hippuryl-his-leu-oh

CAS: 31373-65-6

Formula: C₂₁H₂₇N₅O₅

Purezza: 98%

Peso molecolare: 429.4696

Ref: IN-DA007JNH

(S)-2-((S)-2-(2-Benzamidoacetamido)-3-(1H-imidazol-4-yl)propanamido)-4-methylpentanoic acid

CAS: 31373-65-6

(S)-2-((S)-2-(2-Benzamidoacetamido)-3-(1H-imidazol-4-yl)propanamido)-4-methylpentanoic acid

Purezza: 98%

Peso molecolare: 429.48g/mol

Ref: 54-OR1073976

Hippuryl-His-Leu-OH

CAS: 31373-65-6

Hippuryl-His-Leu-OH tests for angiotensin I enzyme activity, allowing His-Leu detection by fluorescence.

Formula: C₂₁H₂₇N₅O₅

Colore e forma: Solid

Peso molecolare: 429.47

Ref: TM-T76610

Bz-Gly-His-Leu • H2O [Hippuryl-Histidyl-Leucine]

CAS: 31373-65-6

Bz-Gly-His-Leu is a peptide that has the amino acid sequence of Hippuryl-Histidyl-Leucine. The peptide binds to Angiotensin I Converting Enzyme I Substrates and prevents the enzyme from converting Angiotensin I to Angiotensin II, thereby lowering blood pressure. Bz-Gly-His-Leu has been shown to be effective in reducing blood pressure in patients with congestive heart failure as well as those with normal cardiac function.

Formula: C₂₁H₂₇N₅O₅•H₂O

Purezza: Min. 95%

Peso molecolare: 447.49 g/mol

Ref: 3D-SGL-3064

Hippuryl-His-Leu-OH

CAS: 31373-65-6

Hippuryl-His-Leu-OH is a peptide that inhibits the activity of angiotensin converting enzyme (ACE) at a concentration of 50 μM. It has been shown to inhibit cyclase and other enzymes in vitro. The binding of this compound to ACE prevents the conversion of angiotensin I to angiotensin II, which is a potent vasoconstrictor. Hippuryl-His-Leu-OH also has inhibitory properties against atrial natriuretic peptide (ANP), and can be used as an antihypertensive agent. This drug has been shown to have growth factor β1 activities, and can be used for the treatment of cardiac diseases such as myocardial infarction. Structural analysis shows that this drug binds to the active site of ACE, inhibiting its activity by blocking access to substrate or by altering substrate specificity.

Formula: C₂₁H₂₇N₅O₅

Purezza: Min. 95%

Colore e forma: White Powder

Peso molecolare: 429.47 g/mol

Ref: 3D-FH110864