CAS 317318-70-0

GW 501516

Descrizione:

GW 501516, noto anche come Cardarine, è un composto sintetico che appartiene alla classe di farmaci noti come modulatori selettivi del recettore androgeno (SARM). È stato inizialmente sviluppato per il trattamento di malattie metaboliche e cardiovascolari. GW 501516 funge da potente agonista del recettore delta attivato da proliferatori di perossisomi (PPARδ), che svolge un ruolo cruciale nella regolazione del metabolismo degli acidi grassi e dell'omeostasi energetica. Questo composto è noto per il suo potenziale di migliorare la resistenza e promuovere la perdita di grasso, rendendolo popolare tra atleti e bodybuilder, nonostante il suo status controverso nello sport a causa di preoccupazioni relative al miglioramento delle prestazioni. GW 501516 è stato studiato per i suoi effetti sui profili lipidici, sulla sensibilità all'insulina e sulla salute metabolica complessiva. Tuttavia, la sua sicurezza ed efficacia a lungo termine negli esseri umani rimangono sotto indagine e non è approvato per uso medico da parte delle agenzie regolatorie. Come con qualsiasi sostanza, l'uso di GW 501516 comporta potenziali rischi ed effetti collaterali, richiedendo cautela e una ricerca approfondita prima dell'uso.

Formula: C₂₁H₁₈F₃NO₃S₂

InChI: InChI=1/C21H18F3NO3S2/c1-12-9-16(7-8-17(12)28-10-19(26)27)29-11-18-13(2)25-20(30-18)14-3-5-15(6-4-14)21(22,23)24/h3-9H,10-11H2,1-2H3,(H,26,27)

InChI key: InChIKey=YDBLKRPLXZNVNB-UHFFFAOYSA-N

SMILES: C(SC1=CC(C)=C(OCC(O)=O)C=C1)C=2SC(=NC2C)C3=CC=C(C(F)(F)F)C=C3

Sinonimi:

• 2-(4-((2-(4-(Trifluoromethyl)phenyl)-4-methylthiazol-5-yl)methylthio)-2-methylphenoxy)acetic acid
• 2-[2-Methyl-4-[[[4-methyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl]methyl]thio]phenoxy]acetic acid
• 2-[2-Methyl-4-[[[4-methyl-2-[4-(trifluoromethyl)phenyl]thiazol-5-yl]methyl]thio]phenoxy]acetic acid
• Acetic acid, (2-methyl-4-(((4-methyl-2-(4-(trifluoromethyl)phenyl)-5-thiazolyl)methyl)thio)phenoxy)-
• Acetic acid, 2-[2-methyl-4-[[[4-methyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl]methyl]thio]phenoxy]-
• Gw 1516
• Gw 501516
• Gw501516
• [2-Methyl-4-[([4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl]methyl)thio]phenoxy]acetic acid
• {2-Methyl-4-[({4-Methyl-2-[4-(Trifluoromethyl)Phenyl]-1,3-Thiazol-5-Yl}Methyl)Sulfanyl]Phenoxy}Acetic Acid
• GW501516, Free Acid
• ENDUROBOL
• {2-Methyl-4-{{4-methyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl}methylthio}phenoxy}acetic acid
• Cardarine(GW501516, GSK-516)
• {2-Methyl-4-[4-Methyl-2-(4-trifluoroMethyl-phenyl)-thiazol-5-ylMethylsulfanyl]-phenoxy}-acetic acid
• 2-(2-methyl-4-((5-methyl-2-(4-(trifluoromethyl)phenyl)thiazol-4-yl)methylthio)phenoxy)acetic acid
• CARDARINE
• GW501516(GSK-516)
• Aceticacid, [2-Methyl-4-[[[4-Methyl-2-[4-(trifluoroMethyl)phenyl]-5-thiazolyl]Methyl]thio]phenoxy]-(9CI)
• 2-(4-((2-(4-(TRIFLUOROMETHYL)PHENYL)-5-METHYLTHIAZOL-4-YL)METHYLTHIO)-2-METHYLPHENOXY)ACETIC ACID
• 2-[2-methyl-4-[[4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl]methylsulfanyl]phenoxy]acetic acid
• GW 501516, >=98%
• 2-(4-((2-(4-(Trifluoromethyl)phenyl)-5-methylthiazol-4-yl)methylthio)-2-methylphenoxy)acetic
• GW501516/GW1516/GW-1516/GW501516
• GSK-516
• Methyl-methyl-trifluoromethylphenyl -thiazolyl-methylsulfanyl-phenoxy-acetic Acid
• 2-(4-((2-(4-(Trifluoromethyl)phenyl)-4-methylthiazol-5-yl)methylthio)-2-methylphenoxy)acetic a
• GW 1516 ,GSK-516
• GW-501615

Cardarine

CAS: 317318-70-0

Colore e forma: Neat

Ref: 04-C11041800

GW 501516

CAS: 317318-70-0

Formula: C₂₁H₁₈F₃NO₃S₂

Peso molecolare: 453.49

Ref: 4Z-G-237004

GW 501516

CAS: 317318-70-0

GW 501516 (Endurobol) is a effective and highly specifc PPARβ/δ agonist (EC50: 1 nM), with 1000-fold selectivity over hPPARα/γ.

Formula: C₂₁H₁₈F₃NO₃S₂

Purezza: 98.91% - 99.64%

Colore e forma: White Solid

Peso molecolare: 453.50

Ref: TM-T6151

GW501516

CAS: 317318-70-0

Ref: 7W-GW9340

GW 501516 - Bio-X ™

Prodotto controllato

CAS: 317318-70-0

This product is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Formula: C₂₁H₁₈F₃NO₃S₂

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 453.5 g/mol

Ref: 3D-BG300099

GW 501516

Prodotto controllato

CAS: 317318-70-0

Agonist of peroxisome proliferator-activated receptor δ/β (PPARδ/β). The compound activates the nuclear receptor PPARδ downstream signalling and affects hepatic AMPK levels. It boosts the activity of the lipin 1-PPARα-PPARγ coactivator 1 (PGC-1)-α pathway and increases hepatic fatty acid oxidation. It was reported that GW 501516 prevents high-fat diet induced hypertriglyceridemia.

Formula: C₂₁H₁₈F₃NO₃S₂

Purezza: Min. 95%

Colore e forma: White Powder

Peso molecolare: 453.50 g/mol

Ref: 3D-FM23721

GW 501516

Prodotto controllato

CAS: 317318-70-0

Stability No Data available
Applications An experimental drug meant to control lipids and increase the level of HDL, or good cholesterol, in the bloodstream.A cell-permeable, thiazolyl compound that acts as a potent, high affinity, PPARδ agonist. Exhibits selectivity for PPARδ compared to PPARα and PPARγ. Does not exibit any activity against other nuclear or non-nuclear receptors. Reported to increase cholesterol efflux and ABAC1 expression in macrophages, fibroblasts, and intestinal cells. GW 501516 has been found to enhance endurance in mice without any training.
References Oliver, W.R., et al.: Proc. Natl. Acad. Sci., USA, 98, 5306 (2001), Sznaidman, M.L., et al.: Bioorg. Med. Chem. Lett., 13, 1517 (2003), Wang, Y.X., et al.: Cell, 113, 159 (2003); Chem. and Eng. News, p. 9, May 8, 2017

Formula: C₂₁H₁₈F₃NO₃S₂

Colore e forma: Neat

Peso molecolare: 453.50

Ref: TR-G931500

GW 501516

CAS: 317318-70-0

Formula: C₂₁H₁₈F₃NO₃S₂

Purezza: 97%

Colore e forma: Solid

Peso molecolare: 453.4977

Ref: IN-DA007ION