CAS 3190-71-4

N-carbossianidrido di γ-benzil L-glutammato

Descrizione:

N-carbossianidrido di γ-benzil L-glutammato (CAS 3190-71-4) è un imide ciclico derivato dall'acido L-glutammico, caratterizzato dalla sua struttura unica che include un gruppo benzilico attaccato alla posizione gamma della catena laterale del glutammato. Questo composto è un tipo di N-carboxianidride (NCA), noto per il suo ruolo nella sintesi di polipeptidi e proteine attraverso la polimerizzazione ad apertura di anello. Tipicamente è un solido bianco a bianco sporco che è solubile in solventi organici come il diclorometano e il dimetilformammide. La presenza del gruppo benzilico migliora le sue proprietà idrofobiche, rendendolo utile in varie applicazioni, inclusi sistemi di somministrazione di farmaci e biomateriali. Inoltre, N-carbossianidrido di γ-benzil L-glutammato è sensibile all'umidità e deve essere maneggiato in un'atmosfera inerte per prevenire l'idrolisi. La sua reattività e capacità di formare polimeri stabili lo rendono un composto prezioso nella chimica organica sintetica e nella scienza dei materiali.

Formula: C₁₃H₁₃NO₅

InChI: InChI=1S/C13H13NO5/c15-11(18-8-9-4-2-1-3-5-9)7-6-10-12(16)19-13(17)14-10/h1-5,10H,6-8H2,(H,14,17)

InChI key: InChIKey=UGCBVSDSTGUPBC-UHFFFAOYSA-N

SMILES: C(CC(OCC1=CC=CC=C1)=O)C2NC(=O)OC2=O

Sinonimi:

• (+)-(S)-Glutamic acid γ-benzyl ester N-carboxyanhydride
• (S)-benzyl 3-(2,5-dioxooxazolidin-4-yl)propanoate
• 2,5-Dioxo-4-Oxazolidinepropanoic acidPhenylmethyl ester
• 4-Oxazolidinepropanoic acid, 2,5-dioxo-, phenylmethyl ester, (4S)-
• 4-Oxazolidinepropanoic acid, 2,5-dioxo-, phenylmethyl ester, (S)-
• 4-Oxazolidinepropionic acid, 2,5-dioxo-, benzyl ester, <span class="text-smallcaps">L</span>-
• 5-Benzyl <span class="text-smallcaps">L</span>-glutamate N-carboxyanhydride
• 5-Benzyl L-Glutamate N-Carboxyanhydride
• <span class="text-smallcaps">L</span>-Glutamic acid carboxyanhydride γ-benzyl ester
• <span class="text-smallcaps">L</span>-Glutamic acid-γ-benzyl ester N-carboxyanhydride
• <span class="text-smallcaps">L</span>-γ-Benzylglutamic acid carboxyanhydride
• Benzyl glutamate N-carboxyanhydride
• Glu(OBzl)-NCA
• H-Glu(Bzl)-NCA
• H-Glu(Obzl)-Nca
• N-Carboxy-γ-benzyl-<span class="text-smallcaps">L</span>-glutamate anhydride
• N-Carboxyanhydride γ-benzyl <span class="text-smallcaps">L</span>-glutamate
• benzyl 3-[(4S)-2,5-dioxo-1,3-oxazolidin-4-yl]propanoate
• γ-Benzyl <span class="text-smallcaps">L</span>-N-carboxyglutamic anhydride
• γ-Benzyl <span class="text-smallcaps">L</span>-glutamate N-carboxyanhydride
• γ-Benzyl <span class="text-smallcaps">L</span>-glutamate-N-carboxylic anhydride
• γ-Benzyl N-carboxy-<span class="text-smallcaps">L</span>-glutamic anhydride
• γ-Benzyl glutamate N-carboxyanhydride
• γ-Benzyl glutamate NCA
• γ-Benzyl-<span class="text-smallcaps">L</span>-glutamic acid N-carboxyanhydride
• γ-Benzyl-<span class="text-smallcaps">L</span>-glutamic acid carboxyanhydride
• γ-Benzyl-N-carboxy-<span class="text-smallcaps">L</span>-glutamate anhydride
• 4-Oxazolidinepropionic acid, 2,5-dioxo-, benzyl ester, L-

H-GLU(OBZL)-NCA

CAS: 3190-71-4

Formula: C₁₃H₁₃NO₅

Purezza: 97%

Colore e forma: Solid

Peso molecolare: 263.2460

Ref: IN-DA00C0SA

(S)-Benzyl 3-(2,5-dioxooxazolidin-4-yl)propanoate

CAS: 3190-71-4

(S)-Benzyl 3-(2,5-dioxooxazolidin-4-yl)propanoate

Purezza: 99%

Peso molecolare: 263.25g/mol

Ref: 54-OR80482

(4S)-2,5-Dioxo-4-oxazolidinepropanoic Acid Phenylmethyl Ester

Prodotto controllato

CAS: 3190-71-4

Stability Unstable in Solution
Applications (4S)-2,5-Dioxo-4-oxazolidinepropanoic Acid Phenylmethyl Ester was used in the synthesis and physicochemical characterization of reduction-sensitive block copolymer for intracellular delivery of doxorubicin.
References Jain, R., et al.: Langmuir, 28, 15323 (2012);

Formula: C₁₃H₁₃NO₅

Colore e forma: Neat

Peso molecolare: 263.25

Ref: TR-D486830

5-Benzyl L-glutamate N-carboxyanhydride

CAS: 3190-71-4

5-Benzyl L-glutamate N-carboxyanhydride is a reactive derivative of L-glutamic acid, where the amino acid has been cyclised as an N-carboxyanhydride (NCA), a class of reagent known as Leuchs’ anhydrides. 5-Benzyl L-glutamate N-carboxyanhydride reacts with nucleophiles such as alcohols and amines to form esters and amides respectively. The opening of the N-carboxyanhydride to an ester or amide releases the amino acid amine which can also react as a nucleophile leading to polymerisation. These poly-amide polymers have been investigated as delivery platforms of Small Interfering RNA (si-RNA).

Formula: C₁₃H₁₃NO₅

Purezza: Min. 95 Area-%

Colore e forma: White Off-White Powder

Peso molecolare: 263.25 g/mol

Ref: 3D-FB63140

ε-Benzyl-L-glutamic acid carboxylic anhydride

CAS: 3190-71-4

Formula: C₁₃H₁₃NO₅

Purezza: 95%

Colore e forma: Solid

Peso molecolare: 263.249

Ref: 10-F044842