CAS 32385-11-8

Sisomicina

Descrizione:

Sisomicina è un antibiotico aminoglicosidico che viene utilizzato principalmente per trattare infezioni causate da batteri Gram-negativi. È derivato dalla fermentazione del batterio Micromonospora purpurea. Sisomicina mostra un ampio spettro di attività antibatterica, particolarmente efficace contro vari ceppi di Pseudomonas e specie di Enterobacter. Il meccanismo d'azione implica il legame con la subunità ribosomiale 30S, portando all'inibizione della sintesi proteica, che alla fine porta alla morte cellulare batterica. Sisomicina viene tipicamente somministrato per iniezione a causa della sua scarsa biodisponibilità orale. La sua farmacocinetica include l'escrezione renale, richiedendo aggiustamenti della dose nei pazienti con funzione renale compromessa. Sebbene generalmente ben tollerato, gli effetti collaterali potenziali possono includere nefrotossicità e ototossicità, preoccupazioni comuni associate agli aminoglicosidi. La struttura chimica di Sisomicina presenta più gruppi amminici, contribuendo alla sua solubilità e interazione con i ribosomi batterici. Come per tutti gli antibiotici, si raccomanda di effettuare test di suscettibilità appropriati per garantire l'efficacia contro patogeni specifici.

Formula: C₁₉H₃₇N₅O₇·H₂O₄S

InChI: InChI=1/C19H37N5O7.H2O4S/c1-19(27)7-28-18(13(26)16(19)24-2)31-15-11(23)5-10(22)14(12(15)25)30-17-9(21)4-3-8(6-20)29-17;1-5(2,3)4/h3,9-18,24-27H,4-7,20-23H2,1-2H3;(H2,1,2,3,4)/t9-,10+,11-,12+,13?,14-,15+,16-,17-,18-,19+;/m1./s1

InChI key: InChIKey=URWAJWIAIPFPJE-YFMIWBNJSA-N

SMILES: O([C@@H]1[C@@H](O)[C@H](O[C@H]2OC(CN)=CC[C@H]2N)[C@@H](N)C[C@H]1N)[C@@H]3[C@H](O)[C@@H](NC)[C@@](C)(O)CO3

Sinonimi:

• <span class="text-smallcaps">D</smallcap>-Streptamine, O-3-deoxy-4-C-methyl-3-(methylamino)-β-<smallcap>L</smallcap>-arabinopyranosyl-(1→6)-O-[2,6-diamino-2,3,4,6-tetradeoxy-α-<smallcap>D</span>-glycero-hex-4-enopyranosyl-(1→4)]-2-deoxy-
• Antibiotic 66-40
• Antibiotic 6640
• BactoCeaze
• Ensamycin
• O-3-Deoxy-4-C-methyl-3-(methylamino)-β-<span class="text-smallcaps">L</smallcap>-arabinopyranosyl-(1→6)-O-[2,6-diamino-2,3,4,6-tetradeoxy-α-<smallcap>D</smallcap>-glycero-hex-4-enopyranosyl-(1→4)]-2-deoxy-<smallcap>D</span>-streptamine
• Rickamicin
• Sch 13475
• Siseptin
• Sisomicin
• Sisomicina
• Sisomicine
• Dehydrogentamicin Cla
• D-Streptamine, O-3-deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranosyl-(1→6)-O-[2,6-diamino-2,3,4,6-tetradeoxy-α-D-glycero-hex-4-enopyranosyl-(1→4)]-2-deoxy-
• (1S,2S,3R,4S,6R)-4,6-diamino-3-{[(2S,3R)-3-amino-6-(aminomethyl)-3,4-dihydro-2H-pyran-2-yl]oxy}-2-hydroxycyclohexyl 3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranoside
• (1S,2S,3R,4S,6R)-4,6-diamino-3-{[(2S,3R)-3-amino-6-(aminomethyl)-3,4-dihydro-2H-pyran-2-yl]oxy}-2-hydroxycyclohexyl (2xi)-3-deoxy-4-C-methyl-3-(methylamino)-beta-L-erythro-pentopyranoside sulfate (salt)
• (1S,2S,3R,4S,6R)-4,6-diamino-3-{[3-amino-6-(aminomethyl)-3,4-dihydro-2H-pyran-2-yl]oxy}-2-hydroxycyclohexyl 3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranoside
• Sisomicin base
• 4,6-diamino-3-{[3-amino-6-(aminomethyl)-3,4-dihydro-2H-pyran-2-yl]oxy}-2-hydroxycyclohexyl 3-deoxy-4-C-methyl-3-(methylamino)pentopyranoside
• O-3-Deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranosyl-(1→6)-O-[2,6-diamino-2,3,4,6-tetradeoxy-α-D-glycero-hex-4-enopyranosyl-(1→4)]-2-deoxy-D-streptamine
• 6-O-(4-C-Methyl-3-methylamino-3-deoxy-β-L-arabinopyranosyl)-4-O-(2,6-diamino-2,3,4,6-tetradeoxy-α-D-glycero-4-hexenopyranosyl)-2-deoxy-D-streptamine
• O-3-Deoxy-4-C-methyl-3-(methylamino)--L-arabinopyranosyl-(1-6)-O-[2,6-diamino-2,3,4,6-tetradeoxy-a-D-glycero-hex-4-enopyranosyl-(1-4)]-2-deoxy- D-Streptamine
• Sisomicin (C1a oxidation peak)
• Sisomicin base (intermediates)
• SISOMYCIN
• O-3-deoxy-4C-methyl-3-(methylamino)--L-arabinopiranozyl-(1-6)-O[2,6-diamino-2,3,4,6-tetradeooxy-a-D-glycerohexy-4-enopiranozyl-(1-4)]-2-deoxy-D-streptamycin

Sisomicin

CAS: 32385-11-8

Formula: C₁₉H₃₇N₅O₇

Purezza: 97%

Colore e forma: Solid

Peso molecolare: 447.5264

Ref: IN-DA00C0C4

Sisomicin

CAS: 32385-11-8

Sisomicin is a broad-spectrum aminoglycoside antibiotic isolated from Micromonospora inyoensis. It is highly active against staphylococci.

Formula: C₁₉H₃₇N₅O₇

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 447.53

Ref: TM-T20675

Sisomicin (Netilmicin EP Impurity A)

CAS: 32385-11-8

Formula: C₁₉H₃₇N₅O₇

Colore e forma: White To Off-White Solid

Peso molecolare: 447.53

Ref: 4Z-S-080002

Sisomicin

CAS: 32385-11-8

Peso molecolare: 447.53

Ref: 7W-GA4392

Sisomicin

Prodotto controllato

CAS: 32385-11-8

Applications Sisomicin is an Antibacterial. Gentamicin-like aminoglycoside antibiotic; has broad spectrum antibiotic activity.
References Weinstein, M.J., et al.: J. Antibiot., 23, 551 (1970), Sculier, J.P., et al.: J. Antimicrob. Chemother., 9, 63 (1982), Noone, P., et al.: Drugs, 27, 548 (1984),

Formula: C₁₉H₃₇N₅O₇

Colore e forma: Neat

Peso molecolare: 447.53

Ref: TR-S488500

Sisomicin

CAS: 32385-11-8

Sisomicin is an aminoglycoside antibiotic with action on bacterial protein synthesis inhibition and is used for treating severe bacterial infections resistant to other aminoglycosides.

Formula: C₁₉H₃₇N₅O₇

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 447.53 g/mol

Ref: 3D-AS27839

Netilmicin EP Impurity A

CAS: 32385-11-8

Formula: C₁₉H₃₇N₅O₇

Peso molecolare: 447.53

Ref: ST-EA-CP-N94001

Sisomicin Sulfate

CAS: 32385-11-8, 53179-09-2

Formula: C₁₉H₃₇N₅O₇H₂SO₄

Purezza: >98.0%(HPLC)

Colore e forma: White to Almost white powder to crystal

Peso molecolare: 692.71

Ref: 3B-I1049