CAS 327-78-6

Isocianato di 4-cloro-3-(trifluorometil)fenile

Descrizione:

Isocianato di 4-cloro-3-(trifluorometil)fenile, con il numero CAS 327-78-6, è un composto organico caratterizzato dal suo gruppo funzionale isocianato (-N=C=O) attaccato a un anello aromatico clorurato. Questo composto presenta un gruppo trifluorometilico (-CF3) nella posizione meta rispetto al gruppo isocianato, il che influisce significativamente sulla sua reattività chimica e sulle proprietà fisiche. È tipicamente un liquido o solido incolore o giallo pallido, a seconda della temperatura e della purezza. La presenza dei gruppi cloro e trifluorometilico migliora il suo carattere elettrofilo, rendendolo un intermedio utile nella sintesi organica, in particolare nella produzione di farmaci e agrochimici. A causa della sua funzionalità isocianato, può reagire con ammine e alcoli, formando uree e carbammati, rispettivamente. Tuttavia, è importante maneggiare questo composto con cura, poiché gli isocianati sono noti per essere tossici e possono causare irritazione respiratoria. Dovrebbero essere adottate misure di sicurezza adeguate quando si lavora con questa sostanza in un laboratorio o in un contesto industriale.

Formula: C₈H₃ClF₃NO

InChI: InChI=1/C8H3ClF3NO/c9-7-2-1-5(13-4-14)3-6(7)8(10,11)12/h1-3H

InChI key: InChIKey=NBJZEUQTGLSUOB-UHFFFAOYSA-N

SMILES: C(F)(F)(F)C1=CC(N=C=O)=CC=C1Cl

Sinonimi:

• 1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboximidamide
• 1-Chloro-4-isocyanato-2-(trifluoromethyl)benzene
• 3-Trifluoromethyl-4-chlorophenyl isocyanate
• 4-Chloro-1-isocyanato-3-trifluoromethylbenzene
• 4-Chloro-3-(trifluoro methyl)phenyl isocyanate
• 4-Chloro-3-(trifluoromethyl)phenylisocyanate
• 4-Chloro-α,α,α-trifluoro-m-tolyl isocyanate
• Benzene, 1-chloro-4-isocyanato-2-(trifluoromethyl)-
• Isocyanic acid, 4-chloro-α,α,α-trifluoro-m-tolyl ester
• Sorafenib intermediate 3
• 4-Chloro-3-(trifluoromethyl)phenyl isocyanate
• 3-TRIFLUOROMETHYL-4-CHLORO-PHENYL ISOCYANATE

4-Chloro-3-(trifluoromethyl)phenyl Isocyanate

CAS: 327-78-6

Formula: C₈H₃ClF₃NO

Purezza: >98.0%(GC)

Colore e forma: White to Almost white powder to lump

Peso molecolare: 221.56

Ref: 3B-C2778

4-Chloro-3-(trifluoromethyl)phenyl isocyanate, 97%

CAS: 327-78-6

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Formula: C₈H₃ClF₃NO

Purezza: 97%

Colore e forma: Crystals or powder or crystalline powder or fused solid or clear liquid as melt, Colorless to white

Peso molecolare: 221.56

Ref: 02-L12016

4-Chloro-3-(Trifluoromethyl)Phenyl Isocyanate

CAS: 327-78-6

Formula: C₈H₃ClF₃NO

Purezza: 95%

Colore e forma: Solid

Peso molecolare: 221.5637

Ref: IN-DA0033ZD

4-Chloro-3-(trifluoromethyl)phenyl isocyanate

CAS: 327-78-6

4-Chloro-3-(trifluoromethyl)phenyl isocyanate

Purezza: 98%

Peso molecolare: 221.56g/mol

Ref: 54-PC10386

4-Chloro-3-(trifluoromethyl)phenyl isocyanate

CAS: 327-78-6

4-Cl-3-(CF3)phenyl isocyanate made from o-chlorobenzotrifluoride and acetic anhydride.

Formula: C₈H₃ClF₃NO

Purezza: ≥98%

Colore e forma: Solid

Peso molecolare: 221.56

Ref: TM-T77702

4-Chloro-3-(trifluoromethyl)phenyl isocyanate

CAS: 327-78-6

4-Chloro-3-(trifluoromethyl)phenyl isocyanate

Purezza: ≥98%

Peso molecolare: 221.56g/mol

Ref: 54-BUP18562

4-Chloro-3-(trifluoromethyl)phenyl isocyanate

CAS: 327-78-6

Formula: C₈H₃ClF₃NO

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 221.56

Ref: 10-F024252

4-Chloro-3-(trifluoromethyl)phenyl Isocyanate

Prodotto controllato

CAS: 327-78-6

Applications 4-Chloro-3-(trifluoromethyl)phenyl isocyanate is used as a reagent to synthesize pyrimidinylaminobenzene derivatives, compounds that have antiproliferative activity against melanoma cell lines. 4-Chloro-3-(trifluoromethyl)phenyl isocyanate is also used to synthesize α-thymidine analogues that act as antimalarial agents.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Cui, H., et al.: J. Med. Chem., 55, 10948 (2012); Kim, H., et al.: Bull. Kor. Chem. Soc., 34, 2311 (2013)

Formula: C₈H₃ClF₃NO

Colore e forma: Neat

Peso molecolare: 221.56

Ref: TR-C421940

4-Chloro-3-(trifluoromethyl)phenyl isocyanate

CAS: 327-78-6

4-Chloro-3-(trifluoromethyl)phenyl isocyanate (4CTFPI) is a phenoxy that has significant antiproliferative activity and can be used to treat cancer. It can inhibit the growth of tumor cells by suppressing the production of growth factors and binding to the receptor for these factors, which leads to inhibition of cell division. 4CTFPI also inhibits tumor growth through its ability to induce apoptosis in cancer cells. 4CTFPI has been shown to have antitumor effects on sarcoma cells in vitro and in vivo with a low toxicity profile. This compound is not active against bacterial infections or fungi, but it does not show any carcinogenic effects.

Formula: C₈H₃ClF₃NO

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 221.56 g/mol

Ref: 3D-FC03027