CAS 327036-89-5

4-benzil-2-metil-1,2,4-tiadiazolidina-3,5-dione

Descrizione:

4-benzil-2-metil-1,2,4-tiadiazolidina-3,5-dione è un composto eterociclico caratterizzato da un anello a cinque membri contenente atomi di zolfo e azoto. Questo composto presenta un nucleo di tiadiazolidina, che è un derivato del tiadiazolo, ed è sostituito con un gruppo benzilico e un gruppo metilico, contribuendo alle sue uniche proprietà chimiche. La presenza dei gruppi funzionali dione indica che ha due funzionalità carboniliche (C=O), che possono partecipare a varie reazioni chimiche, comprese le aggiunte nucleofile e le reazioni di condensazione. La struttura molecolare suggerisce potenziali applicazioni in chimica medicinale, in particolare nello sviluppo di farmaci, grazie alla presenza della struttura di tiadiazolidina, nota per la sua attività biologica. Inoltre, il composto può presentare interessanti proprietà fisiche come la solubilità in solventi organici e specifici punti di fusione o ebollizione, influenzati dalle sue interazioni molecolari. In generale, 4-benzil-2-metil-1,2,4-tiadiazolidina-3,5-dione rappresenta una struttura versatile con potenziali implicazioni in vari campi chimici e biologici.

Formula: C₁₀H₁₀N₂O₂S

InChI: InChI=1/C10H10N2O2S/c1-11-9(13)12(10(14)15-11)7-8-5-3-2-4-6-8/h2-6H,7H2,1H3

SMILES: Cn1c(=O)n(Cc2ccccc2)c(=O)s1

Sinonimi:

• 1,2,4-Thiadiazolidine-3,5-dione, 2-methyl-4-(phenylmethyl)-
• Tdzd-8

4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione

CAS: 327036-89-5

Formula: C₁₀H₁₀N₂O₂S

Purezza: >98.0%(HPLC)

Colore e forma: White Solid Form

Peso molecolare: 222.26

Ref: 3B-B4436

4-​Benzyl-​2-​methyl-​1,​2,​4-​thiadiazolidine-​3,​5-​dione

CAS: 327036-89-5

Formula: C₁₀H₁₀N₂O₂S

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 222.2636

Ref: IN-DA00C6HT

TDZD-8

CAS: 327036-89-5

TDZD-8

Formula: C₁₀H₁₀N₂O₂S

Purezza: 99.01% (Typical Value in Batch COA)

Colore e forma: white solid

Peso molecolare: 222.26g/mol

Ref: 54-BISN0325

TDZD-8

CAS: 327036-89-5

TDZD-8

Purezza: ≥95%

Peso molecolare: 222.26g/mol

Ref: 54-BUP10327

TDZD-8

CAS: 327036-89-5

Formula: C₁₀H₁₀N₂O₂S

Purezza: ≥ 97.5%

Colore e forma: White to light-yellow to beige powder

Peso molecolare: 222.26

Ref: 7W-GL4346

TDZD-8

CAS: 327036-89-5

TDZD-8 (NP 01139) is an inhibitor of GSK-3β, with an IC50 of 2 μM; minimal inhibitory effect observed on CDK1, casein kinase II, PKA and PKC.

Formula: C₁₀H₁₀N₂O₂S

Purezza: 97.13% - 99.61%

Colore e forma: White Solid

Peso molecolare: 222.26

Ref: TM-T6187

TDZD 8 - Bio-X ™

CAS: 327036-89-5

This product is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Formula: C₁₀H₁₀N₂O₂S

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 222.26 g/mol

Ref: 3D-BT300032

TDZD-8

CAS: 327036-89-5

M02610 - TDZD-8

Formula: C₁₀H₁₀N₂O₂S

Purezza: 90%

Peso molecolare: 222.26

Ref: 10-M02610

4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione

Prodotto controllato

CAS: 327036-89-5

Applications Glycogen Synthase Kinase-3ß is a highly conserved ubiquitously expressed serine/threonine protein kinase involved in signal transduction cascades of multiple cellular processes. TDZD-8 is a thiadiazolidinone (TDZD) analogue that acts as a highly selective, non-ATP competitive inhibitor of GSK-3ß ( IC50 =2nM). Binds to the active site of GSK-3ß. Does not significantly affect the activities of Cdk-1/cyclin B, CK-II, PKA, and PKC (IC50 >100nM).
References Martinez, A., et al.: J. Med. Chem., 45, 1292 (2002)

Formula: C₁₀H₁₀N₂O₂S

Colore e forma: Neat

Peso molecolare: 222.26

Ref: TR-B285725

TDZD 8

CAS: 327036-89-5

TDZD 8 is a selective, non-ATP competitive inhibitor of the glycogen synthase kinase GSK3β. TDZD 8 inhibits GSK3β with IC50 of 2 μM and was reported to not significantly affect Cdk-1/cyclin B, casein kinase CK-II, protein kinase A and C (PKA, PKC) activities. TDZD 8 was also identified as an inhibitor of the main protease in coronaviruses. In an in vitro study, TDZD 8 was characterised as an aggregate-based inhibitor as the presence of Triton-X decreased the inhibitory potency to Mpro protease of the SARS-CoV-2 virus (IC50 without Triton-X: 2.15 μM).

Formula: C₁₀H₁₀N₂O₂S

Purezza: Min. 98 Area-%

Colore e forma: Powder

Peso molecolare: 222.26 g/mol

Ref: 3D-FB18327