CAS 32887-01-7

Mecillinam

Descrizione:

Mecillinam è un antibiotico beta-lattamico che appartiene alla classe delle penicilline, progettato specificamente per attaccare e inibire la sintesi della parete cellulare batterica. È particolarmente efficace contro alcuni batteri Gram-negativi, comprese ceppi di Escherichia coli e Proteus mirabilis. Mecillinam funziona legandosi alle proteine di legame della penicillina (PBP), che sono essenziali per il cross-linking degli strati di peptidoglicano nelle pareti cellulari batteriche, portando infine alla lisi cellulare e alla morte. Questo antibiotico è caratterizzato dalla sua tossicità relativamente bassa per le cellule umane, rendendolo un'opzione adatta per il trattamento delle infezioni del tratto urinario e di altre infezioni batteriche. Mecillinam viene spesso somministrato per via orale ed è noto per la sua stabilità in presenza di alcune beta-lattamasi, anche se può essere suscettibile ad altre. Le sue proprietà farmacocinetiche includono una buona assorbimento e distribuzione nel corpo, con l'escrezione renale che rappresenta una via principale di eliminazione. In generale, Mecillinam rappresenta un prezioso agente terapeutico nell'arsenale contro le infezioni batteriche, in particolare quelle causate da ceppi resistenti.

Formula: C₁₅H₂₃N₃O₃S

InChI: InChI=1S/C15H23N3O3S/c1-15(2)11(14(20)21)18-12(19)10(13(18)22-15)16-9-17-7-5-3-4-6-8-17/h9-11,13H,3-8H2,1-2H3,(H,20,21)/t10-,11+,13-/m1/s1

InChI key: InChIKey=BWWVAEOLVKTZFQ-NTZNESFSSA-N

SMILES: C(O)(=O)[C@@H]1N2[C@@]([C@H](N=CN3CCCCCC3)C2=O)(SC1(C)C)[H]

Sinonimi:

• (2S,5R,6R)-6-[(azepan-1-ylmethylidene)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
• (2S,5R,6R)-6-[[(Hexahydro-1H-azepin-1-yl)methylene]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
• (2S,5R,6R)-6-{[(E)-azepan-1-ylmethylidene]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
• 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[(hexahydro-1H-azepin-1-yl)methylene]amino]-3,3-dimethyl-7-oxo-, (+)-
• 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[(hexahydro-1H-azepin-1-yl)methylene]amino]-3,3-dimethyl-7-oxo-, (2S,5R,6R)-
• 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[(hexahydro-1H-azepin-1-yl)methylene]amino]-3,3-dimethyl-7-oxo-, [2S-(2α,5α,6β)]-
• 6-[[(Hexahydro-1H-azepin-1-yl)methylene]amino]penicillanic acid
• 6-[β-(Hexahydro-1H-azepin-1-yl)methylenamino]penicillanic acid
• 6β-[(Hexahydro-1H-azepin-1-yl)methyleneamino]penicillanic acid
• Amdinocillin
• Coactin
• Fl 1060
• Hexacillin
• Hexapen
• Mecilinamo
• Penicillin Hx
• [(2,2-dimethylpropanoyl)oxy]methyl (5R,6R)-6-{[(E)-azepan-1-ylmethylidene]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate

Mecillinam, 90+%

CAS: 32887-01-7

Effective against gram negative bacteria

Formula: C₁₅H₂₃N₃O₃S

Purezza: 90+%

Colore e forma: Powder, White to off-white

Peso molecolare: 325.43

Ref: 02-J66774

(2S,5R,6R)-6-(azepan-1-ylmethylideneamino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid

CAS: 32887-01-7

Formula: C₁₅H₂₃N₃O₃S

Colore e forma: Solid

Peso molecolare: 325.4264

Ref: IN-DA00JKJ5

Mecillinam

CAS: 32887-01-7

Mecillinam

Purezza: ≥95%

Peso molecolare: 325.43g/mol

Ref: 54-BUP11179

Mecillinam

CAS: 32887-01-7

Formula: C₁₅H₂₃N₃O₃S

Purezza: ≥ 95%

Colore e forma: White crystalline powder

Peso molecolare: 325.43

Ref: 7W-GA6807

Mecillinam-d12

CAS: 32887-01-7

Formula: C₁₅H₁₁D₁₂N₃O₃S

Colore e forma: Pale Yellow Solid

Peso molecolare: 337.50

Ref: 4Z-M-156002

Mecillinam

CAS: 32887-01-7

Formula: C₁₅H₂₃N₃O₃S

Peso molecolare: 325.43

Ref: 4Z-M-156001

Mecillinam

CAS: 32887-01-7

Mecillinam, an antibiotic, targets Gram-negative bacteria, mainly for urinary infections and some fevers.

Formula: C₁₅H₂₃N₃O₃S

Purezza: 95.53% - ≥95%

Colore e forma: Solid

Peso molecolare: 325.43

Ref: TM-T21369

Amdinocillin (>85%)

Prodotto controllato

CAS: 32887-01-7

Formula: C₁₅H₂₃N₃O₃S

Purezza: ~85%

Colore e forma: Neat

Peso molecolare: 325.43

Ref: TR-A576405

Amdinocillin

CAS: 32887-01-7

Amdinocillin is a semisynthetic antibiotic with broad-spectrum activity that is part of the aminopenicillin family. It is used in the treatment of bacterial infections such as those caused by Gram-negative bacteria, and to treat methicillin-resistant Staphylococcus (MRSA). The clinical isolate Amdinocillin has an inhibitory concentration (IC) of 0.25 μg/mL against Enterobacter aerogenes and Enterobacter cloacae, and it displays a synergistic effect in combination with other antibiotics. The mechanism of action is that prevents bacterial growth and proliferation by inhibiting cell wall synthesis and causing lysis, which allows for drug therapy against specific types of bacteria.

Formula: C₁₅H₂₃N₃O₃S

Purezza: (%) Min. 97%

Colore e forma: White Slightly Yellow Powder

Peso molecolare: 325.43 g/mol

Ref: 3D-AA17347

Mecillinam (MCL) extrapure, 95%

CAS: 32887-01-7

Formula: C₁₅H₂₃N₃O₃S

Purezza: min. 95.0%

Colore e forma: White to Light yellow to Light beige, Powder

Peso molecolare: 325.43

Ref: SR-54474

Amdinocillin

Prodotto controllato

CAS: 32887-01-7

Applications Active antibacterial against gram-negative bacteria.
References Cagnacci, S., et al.: J. Clin. Microbiol., 46, 2605 (2008), Obach, R., et al.: Drug Metab. Disposition, 36, 1385 (2008), Ma, C., et al.: J. Pharm. Biomed. Anal., 47, 677 (2008),

Formula: C₁₅H₂₃N₃O₃S

Colore e forma: White

Peso molecolare: 325.43

Ref: TR-A576300

Mecillinam, Antibiotic for Culture Media Use Only

CAS: 32887-01-7

Mecillinam is a beta-lactam antibiotic specifically designed for use in culture media. It is derived from the amidinopenicillin family, featuring a unique ability to interfere with bacterial cell wall synthesis. Its mode of action involves inhibiting penicillin-binding protein 2 (PBP2), an essential enzyme for cell wall elongation and maintenance in Gram-negative bacteria. This targeted inhibition results in the formation of spherical cells and subsequent cell lysis.

Formula: C₁₅H₂₃N₃O₃S

Purezza: Min. 95 Area-%

Peso molecolare: 325.43 g/mol

Ref: 3D-Q-201343