CAS 32986-56-4

Tobramicina

Descrizione:

Tobramicina è un antibiotico aminoglicosidico utilizzato principalmente per trattare infezioni causate da batteri Gram-negativi, in particolare Pseudomonas aeruginosa. È efficace contro una serie di infezioni batteriche, specialmente in pazienti con fibrosi cistica o con sistemi immunitari compromessi. La sostanza è caratterizzata dalla sua capacità di inibire la sintesi proteica batterica legandosi alla subunità ribosomiale 30S, portando a una lettura errata dell'mRNA e, infine, alla morte cellulare. Tobramicina viene tipicamente somministrato per inalazione, iniezione o applicazione topica, a seconda della posizione e della gravità dell'infezione. È noto per la sua tossicità relativamente bassa rispetto ad altri aminoglicosidi, anche se può comunque causare nefrotossicità e ototossicità, richiedendo un attento monitoraggio della funzione renale e dell'udito durante il trattamento. La struttura chimica di Tobramicina include più gruppi idrossile e amminici, contribuendo alla sua solubilità e attività biologica. Come per tutti gli antibiotici, l'emergere di resistenza è una preoccupazione, rendendo essenziale un uso appropriato e l'adesione ai regimi prescritti per mantenere la sua efficacia.

Formula: C₁₈H₃₇N₅O₉

InChI: InChI=1/C20H41N5O7/c21-5-8-1-7(10(22)4-13(8)27)2-9-11(23)3-12(24)19(16(9)28)32-20-18(30)15(25)17(29)14(6-26)31-20/h7-20,26-30H,1-6,21-25H2

InChI key: InChIKey=NLVFBUXFDBBNBW-PBSUHMDJSA-N

SMILES: O([C@@H]1[C@@H](O)[C@H](O[C@H]2O[C@H](CN)[C@@H](O)C[C@H]2N)[C@@H](N)C[C@H]1N)[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O

Sinonimi:

• (1S,2S,3R,4S,6R)-4,6-diamino-3-[(2,6-diamino-2,3,6-trideoxy-alpha-D-ribo-hexopyranosyl)oxy]-2-hydroxycyclohexyl 3-amino-3-deoxy-alpha-D-glucopyranoside
• 3'-Deoxykanamycin B
• 4-Amino-2-[4,6-Diamino-3-[[2-Amino-5-(Aminomethyl)-4-Hydroxy-Cyclohexyl]Methyl]-2-Hydroxy-Cyclohexoxy]-6-(Hydroxymethyl)Tetrahydropyran-3,5-Diol
• <span class="text-smallcaps">D</smallcap>-Streptamine, O-3-amino-3-deoxy-α-<smallcap>D</smallcap>-glucopyranosyl-(1→6)-O-[2,6-diamino-2,3,6-trideoxy-α-<smallcap>D</span>-ribo-hexopyranosyl-(1→4)]-2-deoxy-
• D-Streptamine, O-3-amino-3-deoxy-α-D-glucopyranosyl-(1→6)-O-[2,6-diamino- 2,3,6-trideoxy-α-D-ribo-hexopyranosyl-(1→4)]-2-deoxy-
• Deoxykanamycin B
• Nebramycin 6
• Nebramycin VI
• Nebramycin factor 6
• Nf 6
• Nsc 180514
• O-3-Amino-3-deoxy-α-<span class="text-smallcaps">D</smallcap>-glucopyranosyl-(1→6)-O-[2,6-diamino-2,3,6-trideoxy-α-<smallcap>D</smallcap>-ribo-hexopyranosyl-(1→4)]-2-deoxy-<smallcap>D</span>-streptamine
• O-3-Amino-3-deoxy-α-D-glucopyranosyl-(1→4)-O-[2,6-diamino-2,3,6-trideoxy-α-D-ribo-hexopyranosyl-(1→6)]-2-deoxystreptamine
• O-3-Amino-3-deoxy-α-D-glucopyranosyl-(1→6)-O-[2,6-diamino-2,3,6-trideoxy-α-D-ribo-hexopyranosyl-(1→4)]-2-deoxy-D-streptamine
• Streptamine, O-3-amino-3-deoxy-α-D-glucopyranosyl-(1→4)-O-[2,6-diamino-2,3,6-trideoxy-α-D-ribo-hexopyranosyl-(1→6)]-2-deoxy-, D-
• Tobi Podhaler
• Tobracin
• Tobradistin
• Tobralex
• Tobramax
• Tobramaxin
• Tobramicin
• Tobramicina
• Tobramycetin
• Tobramycin Base
• Tobramycin, Free Base
• Tobramycine
• Tobrex
• Tobrin
• Vantobra
• Tobramycin
• o-3-amino-3-deoxy-alpha-d-glucopyranosyl-(1-6)-o-[2,6-diamino-2,3,6-trideoxy-a
• TOBRAMYCIN (RE-EXPORT OF REJECTED MATERIAL RETURN TO VENDOR)
• TobramycinSulphate49842-07-1/Base
• 3’-deoxykanamycinb
• Tobramycin, Antibiotic for Culture Media Use Only
• Tobramycin,O-[3-Amino-3-deoxy-α-D-glucopyranosyl-(1→6)]-O-[2,6-diamino-2,3,6-trideoxy-α-D-ribohexopyranosyl-(1→4)]-2-deoxy-D-streptamine
• O-3-Amino-3-deoxy-alpha-D-glucopyranosyl-(1-6)-O-(2,6-
• Streptamine, O-3-amino-3-deoxy-a-D-glucopyranosyl-(14)-O-[2,6-diamino-2,3,6-trideoxy-a-D-ribo-hexopyranosyl-(16)]-2-deoxy-, D- (8CI)
• o-[3-amino-3-deoxy-α-d-glucopyranosyl-(1→6)]-o-[2,6-diamino-2,3,6-trideoxy-α-d-ribohexopyranosyl-(1→4)]-2-deoxy-d-streptamine
• (2S,3R,4S,5S,6R)-4-amino-2-[(1S,2S,3R,4S,6R)-4,6-diamino-3-[(2R,3R,5S,6R)-3-amino-6-(aminomethyl)-5-hydroxy-oxan-2-yl]oxy-2-hydroxy-cyclohexyl]oxy-6-(hydroxymethyl)oxane-3,5-diol
• 1-epitobramycin
• O-3-Amino-3-deoxy-alpha-D-glucopyranosyl-(1-4)-O-(2,6-diamino-2,3,6-trideoxy-alpha-D-ribohexopyranosyl-(1-4))-2-deoxy-D-streptamine
• streptamine,o-3-amino-3-deoxy-alpha-d-glucopyranosyl-(1-4)-o-(2,6-diamino-2,3,
• Tobramycin (base and/or unspecified salts)
• obracin
• gernebcin
• 4-[2,6-diamino-2,3,6-trideoxy-alpha-d-glycopyranosyl]-6-[3-amino-3-deoxy-alpha
• nebcin
• nebramycin6
• d-6-trideoxy-alpha-d-ribohexopyranosyl-(1-6))-2-deoxy
• >D-Streptamine, O-3-amino-3-deoxy-.alpha.-D-glucopyranosyl-(1?6)-O-2,6-diamino-2,3,6-trideoxy-.alpha.-D-ribo-hexopyranosyl-(1?4)-2-deoxy-
• O-[3-Amino-3-deoxy-a-D-glucopyranosyl-(1[R]6)]-O-[2,6-diamino-2,3,6-trideoxy-a-D-ribohexopyranosyl-(1[R]4)]-2-deoxy-D-streptamine
• distobram
• -d-glycopyranosyl]-2-deoxystreptamine
• O-[3-AMINO-3-DEOXY-ALPHA-D-GLUCOPYRANOSYL-(1->6)]-O-[2,6-DIAMINO-2,3,6-TRIDEOXY-ALPHA-D-RIBOHEXOPYRANOSYL-(1->4)]-2-DEOXY-D-STREPTAMINE
• O-3-Amino-3-deoxy-a-D-glucopyranosyl-(14)-O-[2,6-diamino-2,3,6-trideoxy-a-D-ribo-hexopyranosyl-(16)]-2-deoxystreptamine
• 6-trideoxy-alpha-d-ribo-hexopyranosyl-(1-4))-2-deoxy-
• tobra
• TobraMycin Base API
• nebramycinvi
• lpha-d-ribohexopyranosyl-(1-4)]-2-deoxy-d-streptamine
• d-6-tyrideoxy-alpha-d-ribohexopyranosyl-(1-6))-2-deoxy
• obramycin
• D-Streptamine, O-3-amino-3-deoxy-a-D-glucopyranosyl-(16)-O-[2,6-diamino-2,3,6-trideoxy-a-D-ribo-hexopyranosyl-(14)]-2-deoxy- (9CI)
• O-[3-Amino-3-deoxy-α-D-glucopyranosyl-(1→6)]-O-[2,6-diamino-2,3,6-trideoxy-α-D-ribohexopyranosyl-(1→4)]-2-deoxy-D-streptamine
• deoxykanamycinb
• nebramycinfactor6
• nebicina
• nf6
• Tobramycin (350 mg)
• O-[3-Amino-3-deoxy-alpha-D-glucopyranosyl-(1→6)]-O-[2,6-diamino-2,3,6-trideoxy-alpha-D-ribohexopyranosyl-(1→4)]-2-deoxy-D-streptamine

Tobramycin

CAS: 32986-56-4

Formula: C₁₈H₃₇N₅O₉

Purezza: >94.0%(T)

Colore e forma: White to Orange to Green powder to crystal

Peso molecolare: 467.52

Ref: 3B-T2503

Tobramycin, 900&mu;g/mg

CAS: 32986-56-4

Tobramycin, 900g/mg

Formula: C₁₈H₃₇N₅O₉

Colore e forma: White to pale cream, Powder

Peso molecolare: 467.52

Ref: 02-J66040

SECOND INTERNATIONAL STANDARD FOR TOBRAMYCIN

CAS: 32986-56-4

SECOND INTERNATIONAL STANDARD FOR TOBRAMYCIN

Formula: C₁₈H₃₇N₅O₉

Peso molecolare: 467.5145

Ref: 41-ISA_82_510

TOBRAMYCIN CRS

CAS: 32986-56-4

TOBRAMYCIN CRS

Ref: 41-T1500000

TOBRAMYCIN FOR IDENTIFICATION CRS

CAS: 32986-56-4

TOBRAMYCIN FOR IDENTIFICATION CRS

Formula: C₁₈H₃₇N₅O₉

Colore e forma: White. Powder.

Peso molecolare: 467.5145

Ref: 41-Y0001210

Tobramycin

CAS: 32986-56-4

Aminoglycoside antibiotics

Formula: C₁₈H₃₇N₅O₉

Colore e forma: White Off-White Powder

Peso molecolare: 467.25913

Ref: 45-1667508

Tobramycin

CAS: 32986-56-4

Tobramycin (NSC-180514) is an aminoglycoside, broad-spectrum antibiotic produced by Streptomyces tenebrarius.

Formula: C₁₈H₃₇N₅O₉

Purezza: 99.21% - 99.87%

Colore e forma: White Solid

Peso molecolare: 467.51

Ref: TM-T1255

Tobramycin

CAS: 32986-56-4

Formula: C₁₈H₃₇N₅O₉

Purezza: 95%

Colore e forma: Solid

Peso molecolare: 467.5145

Ref: IN-DA00I6BT

Tobramycin

CAS: 32986-56-4

Tobramycin

Formula: C₁₈H₃₇N₅O₉

Purezza: >97% by area (tlc) (Typical Value in Batch COA)

Colore e forma: white powder

Peso molecolare: 467.51448g/mol

Ref: 54-BIT0802

Tobramycin, EP grade

CAS: 32986-56-4

Formula: C₁₈H₃₇N₅O₉

Purezza: ≤ 0.5%

Colore e forma: White to off-white powder

Peso molecolare: 467.5

Ref: 7W-GA9008

Tobramycin

CAS: 32986-56-4

Tobramycin

Purezza: ≥98%

Peso molecolare: 467.51g/mol

Ref: 54-BUP15965

Tobramycin

CAS: 32986-56-4

Formula: C₁₈H₃₇N₅O₉

Purezza: ≥ 900μg/mg (anhydrous basis)

Colore e forma: White or almost white powder

Peso molecolare: 467.5

Ref: 7W-GA9878

Tobramycin

Prodotto controllato

CAS: 32986-56-4

Formula: C₁₈H₃₇N₅O₉

Colore e forma: Neat

Peso molecolare: 467.51

Ref: 04-CA17588000

Tobramycin

CAS: 32986-56-4

Tobramycin

Formula: C₁₈H₃₇N₅O₉

Colore e forma: White Solid

Peso molecolare: 467.5145

Ref: 47-333

Tobramycin

Prodotto controllato

CAS: 32986-56-4

Applications Single factor antibiotic comprising about 10% of nebramycin, the aminoglycosidic antibiotic complex produced by Streptomyces tenebrarius. Antibacterial.
References Koch, K.F., et al.: Antimicrob. Agents Chemother., 309 (1970), Welles, J.S., et al.: Toxicol. Appl. Pharmacol., 22, 332 (1972), Dash, A.K., et al.: Anal. Profiles Drug Subs. Excip., 24, 579 (1996),

Formula: C₁₈H₃₇N₅O₉

Colore e forma: White To Off-White

Peso molecolare: 467.51

Ref: TR-T524000

Tobramycin-D, 18O Acetic Acid Salt

Prodotto controllato

CAS: 32986-56-4

Formula: C₁₈H₃₆DN₅O₈O·(xCH₃COOH)

Colore e forma: Off White Solid

Peso molecolare: 470.52 +(x60.05)

Ref: TR-T524003

Tobramycin Sulphate Salt

CAS: 32986-56-4, 49842-07-1

Formula: C₁₈H₃₇N₅O₉•x(H₂O₄S)

Colore e forma: Neat

Peso molecolare: 467.51+x(98.08)

Ref: TR-T524033

Tobramycin Deuterated

Prodotto controllato

CAS: 32986-56-4

Stability Hygroscopic
Applications Single factor antibiotic comprising about 10% of nebramycin, the aminoglycosidic antibiotic complex produced by Streptomyces tenebrarius. Antibacterial.A representative lot contains d4, d5, d6, d7, d8, and d9.
References Koch, K.F., et al.: Antimicrob. Agents Chemother., 309 (1970), Welles, J.S., et al.: Toxicol. Appl. Pharmacol., 22, 332 (1972), Dash, A.K., et al.: Anal. Profiles Drug Subs. Excip., 24, 579 (1996),

Formula: C₁₈H₃₇N₅O₉forundeuterated

Colore e forma: Dark Yellow

Peso molecolare: 467.51

Ref: TR-T524002

Tobramycin

CAS: 32986-56-4

Tobramycin used to treat severe infections with gram-negative bacteria and it is often applied in combination with beta-lactams. It has similar antimicrobial effects to gentamicin and is effective against all Enterobacteriacae, but more effective than gentamicin against P. aeruginosa, which is why it is often used for gentamicin-resistant strains, especially in the case of cystic fibrosis.

Formula: C₁₈H₃₇N₅O₉

Purezza: Min. 97 Area-%

Colore e forma: White Powder

Peso molecolare: 467.51 g/mol

Ref: 3D-AT161114

Tobramycin - high purity

CAS: 32986-56-4

Inhibitor of protein synthesis; aminoglycoside

Formula: C₁₈H₃₇N₅O₉

Purezza: Min. 900 Ug/Mg

Colore e forma: Powder

Peso molecolare: 467.51 g/mol

Ref: 3D-AT16493