CAS 33017-11-7

Frammento di peptide C 3-33

Descrizione:

Frammento di peptide C 3-33, associato al numero CAS 33017-11-7, è un peptide derivato dalla molecola di proinsulina, specificamente dalla regione del peptide connettivo (C-peptide). Questo frammento è composto da aminoacidi da 3 a 33 della sequenza del C-peptide, che gioca un ruolo cruciale nel processamento della proinsulina in insulina. Il C-peptide stesso viene rilasciato nel flusso sanguigno in quantità equimolari con l'insulina, fungendo da utile biomarcatore per la produzione di insulina nel corpo. Il frammento 3-33 è di interesse nella ricerca relativa al diabete e ai disturbi metabolici, poiché potrebbe avere implicazioni per comprendere la secrezione e l'azione dell'insulina. Caratteristicamente, questo peptide è idrofobico, il che influisce sulla sua solubilità e interazione con i sistemi biologici. Viene tipicamente sintetizzato utilizzando tecniche di sintesi peptidica in fase solida e può essere analizzato attraverso metodi come la spettrometria di massa e la cromatografia liquida ad alte prestazioni (HPLC). La sua attività biologica e le potenziali applicazioni terapeutiche sono oggetto di ricerca in corso, in particolare nel contesto della gestione e del trattamento del diabete.

Formula: C₁₂₉H₂₁₁N₃₅O₄₈

Sinonimi:

• Proinsulin C-peptide (human)
• C-Peptide, Proinsulin
• Human proinsulin C-peptide

C-Peptide (human)

CAS: 33017-11-7

Bachem ID: 4068086.

Formula: C₁₂₉H₂₁₁N₃₅O₄₈

Purezza: 96.0%

Colore e forma: White Lyophilisate

Peso molecolare: 3020.3

Ref: 01-4068086

C-Peptide (human)

CAS: 33017-11-7

The measurement of the C-peptide under standardized conditions provides a sensitive, well accepted, and clinically validated assessment of β-cell function. The C-peptide measurement is the most suitable primary outcome for clinical trials of therapies aimed at preserving or improving endogenous insulin secretion in type 1 diabetes patients. C-peptide also shows hormonal activity. Clinical studies demonstrated that C-peptide administration in type 1 diabetes patients, who lack the peptide, alleviates the diabetes-induced renal and nerve dysfunctions.

Formula: C₁₂₉H₂₁₁N₃₅O₄₈

Purezza: 96.2%

Colore e forma: White

Peso molecolare: 3020.3

Ref: 01-4009494

Proinsulin C-peptide (human)

CAS: 33017-11-7

C-peptide, a 31-amino acid, links Proinsulin A & B chains for correct folding and function.

Formula: C₁₂₉H₂₁₁N₃₅O₄₈

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 3020.26

Ref: TM-TP1651

Proinsulin C-peptide (human)

CAS: 33017-11-7

Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool

Formula: C₁₂₉H₂₁₁N₃₅O₄₈

Peso molecolare: 3,020.26 g/mol

Ref: 3D-PP49951

C-Peptide (Human)

CAS: 33017-11-7

C-peptide is a peptide hormone that is cleaved from proinsulin in the pancreatic beta cells. Both C-peptide and insulin are released by the beta cells in the event of glycaemia. Due to it having a relatively long half life, compared to insulin, and the fact it is not immediately metabolised by the liver, makes C-peptide a useful biomarker to monitor beta cell function. Increased levels of C-peptide occurring in patients with insulin resistant type 2 diabetes mellitus, have been associated with macrovascular complications and cardiovascular morbidity. During in vitro studies it has also been found that C-peptide prevents endothelial cell reactive oxygen species from being formed and therefore oxidative stress is reduced. This also may lead to anti-inflammatory and anti-apoptotic responses.

Formula: C₁₂₉H₂₁₁N₃₅O₄₈

Purezza: Min. 95%

Peso molecolare: 3,020.27 g/mol

Ref: 3D-PCP-3725-PI

C-Peptide (human) acetate salt

CAS: 33017-11-7

C-Peptide (human) acetate salt H-Glu-Ala-Glu-Asp-Leu-Gln-Val-Gly-Gln-Val-Glu-Leu-Gly-Gly-Gly-Pro-Gly-Ala -Gly Ser Leu Gln Pro Leu Ala Leu Glu Gly Ser Leu Gln Pro Leu Ala is a peptide that has been purified from the pancreas of human and bovine sources. It is used in blood sampling and rate constant experiments to measure the response element on a signal peptide. This experiment can be used to study insulin production, as well as other biological samples. C Peptide (human) acetate salt H Glu Ala Glu Asp Leu Gln Val Gly Gln Val Glu Leu Gly Gly Gly Pro Gly Ala Gly Ser Leu Gln Pro Leu Ala has inhibitory properties against

Formula: C₁₂₉H₂₁₁N₃₅O₄₈

Purezza: Min. 95%

Peso molecolare: 3,020.26 g/mol

Ref: 3D-FP110235

C-Peptide (human) trifluoroacetate salt

CAS: 33017-11-7

C-Peptide is a monoclonal antibody that binds to the β-cell and inhibits insulin release. It has been used in diagnosis of type 1 diabetes mellitus. C-Peptide is a hormone that regulates blood glucose levels by controlling the rate of glucose production in the liver, as well as by inhibiting the breakdown of glycogen in the liver. The C-terminal amino acid sequence Glu-Ala-Glu-Asp-Leu-Gln-Val-Gly-Gln-Val-Glu -Leu-Gly can be cleaved from the peptide by trifluoroacetic acid to yield free Gln, which can then be detected using mass spectrometry. Growth factors such as IGF1, FGF21, and HGF have been shown to increase C peptide levels in diabetic patients.

Formula: C₁₂₉H₂₁₁N₃₅O₄₈

Purezza: Min. 95%

Peso molecolare: 3,020.26 g/mol

Ref: 3D-FP108679