CAS 330784-47-9

Avanafil

Descrizione:

Avanafil è un inibitore selettivo della fosfodiesterasi di tipo 5 (PDE5) utilizzato principalmente per il trattamento della disfunzione erettile. È caratterizzato da un rapido inizio d'azione, tipicamente entro 15-30 minuti dopo la somministrazione, rendendolo una scelta popolare tra i pazienti che cercano un sollievo rapido. La struttura chimica di Avanafil include un nucleo di pirazolo[3,4-d]pirimidina, che contribuisce alla sua attività farmacologica. Ha un'alta affinità per l'enzima PDE5, portando a livelli aumentati di monofosfato di guanosina ciclico (cGMP) nel corpo cavernoso, facilitando l'erezione peniena in risposta alla stimolazione sessuale. Avanafil è generalmente ben tollerato, con un profilo di effetti collaterali che può includere mal di testa, arrossamento, congestione nasale e mal di schiena. È importante notare che Avanafil non dovrebbe essere usato in concomitanza con nitrati a causa del rischio di ipotensione significativa. Come per qualsiasi farmaco, è essenziale che i pazienti consultino professionisti sanitari per un uso appropriato e potenziali interazioni.

Formula: C₂₃H₂₆ClN₇O₃

InChI: InChI=1S/C23H26ClN7O3/c1-34-19-6-5-15(10-18(19)24)11-27-21-17(22(33)28-13-20-25-7-3-8-26-20)12-29-23(30-21)31-9-2-4-16(31)14-32/h3,5-8,10,12,16,32H,2,4,9,11,13-14H2,1H3,(H,28,33)(H,27,29,30)/t16-/m0/s1

InChI key: InChIKey=WEAJZXNPAWBCOA-INIZCTEOSA-N

SMILES: C(O)[C@H]1N(C=2N=C(NCC3=CC(Cl)=C(OC)C=C3)C(C(NCC=4N=CC=CN4)=O)=CN2)CCC1

Sinonimi:

• (S)-2-(2-Hydroxymethyl-1-pyrrolidinyl)-4-(3-chloro-4-methoxybenzylamino)-5-[(2-pyrimidinylmethyl)carbamoyl]pyrimidine
• (S)-2-(2-Hydroxymethyl-1-pyrrolidinyl)-4-(3-chloro-4-methoxybenzylamino)-5-[N-(2-pyrimidinylmethyl)carbamoyl]pyrimidine
• (S)-4-[(3-Chloro-4-methoxybenzyl)amino]-2-[2-(hydroxymethyl)-1-pyrrolidinyl]-N-(2-pyrimidinylmethyl)-5-pyrimidinecarboxamide
• 4-[(3-Chloro-4-methoxybenzyl)amino]-2-[2-(hydroxymethyl)-1-pyrrolidinyl]-N-(2-pyrimidinylmethyl)-5-pyrimidinecarboxamide
• 4-[(3-chloro-4-methoxybenzyl)amino]-2-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]-N-(pyrimidin-2-ylmethyl)pyrimidine-5-carboxamide
• 4-[[(3-Chloro-4-methoxyphenyl)methyl]amino]-2-[(2S)-2-(hydroxymethyl)-1-pyrrolidinyl]-N-(2-pyrimidinylmethyl)-5-pyrimidinecarboxamide
• 5-Pyrimidinecarboxamide, 4-[[(3-chloro-4-methoxyphenyl)methyl]amino]-2-[(2S)-2-(hydroxymethyl)-1-pyrrolidinyl]-N-(2-pyrimidinylmethyl)-
• Spedra
• Ta 1790
• Avanafil

Avanafil

CAS: 330784-47-9

Colore e forma: Neat

Ref: 61-FOR3313.00

(S)-2-(2-Hydroxymethyl-1-pyrrolidinyl)-4-(3-chloro-4-methoxybenzylamino)-5-[(2-pyrimidinylmethyl)carbamoyl]pyrimidine

CAS: 330784-47-9

Formula: C₂₃H₂₆ClN₇O₃

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 483.9506

Ref: IN-DA0034HA

Avanafil

CAS: 330784-47-9

Avanafil

Purezza: ≥98%

Peso molecolare: 483.95g/mol

Ref: 54-BUP17735

Avanafil

CAS: 330784-47-9

Formula: C₂₃H₂₆ClN₇O₃

Colore e forma: White To Off-White Solid

Peso molecolare: 483.96

Ref: 4Z-A-291

4-[(3-Chloro-4-methoxybenzyl)amino]-2-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]-N-(pyrimidin-2-ylmethyl)pyrimidine-5-carboxamide

CAS: 330784-47-9

4-[(3-Chloro-4-methoxybenzyl)amino]-2-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]-N-(pyrimidin-2-ylmethyl)pyrimidine-5-carboxamide

Purezza: 98%

Peso molecolare: 483.95064g/mol

Ref: 54-OR302290

Avanafil Impurity 12

CAS: 330784-47-9

Formula: C₂₈H₃₀ClN₉O₃

Colore e forma: Off-White Solid

Peso molecolare: 576.06

Ref: 4Z-A-2917

Avanafil 100 µg/mL in Acetonitrile:Dimethylsulfoxide

CAS: 330784-47-9

Formula: C₂₃H₂₆ClN₇O₃

Colore e forma: Single Solution

Peso molecolare: 483.95

Ref: 04-A10333900DL-100

Avanafil

CAS: 330784-47-9

Formula: C₂₃H₂₆ClN₇O₃

Purezza: >98.0%(T)(HPLC)

Colore e forma: White to Light yellow powder to crystal

Peso molecolare: 483.96

Ref: 3B-A3476

Avanafil

Prodotto controllato

CAS: 330784-47-9

Formula: C₂₃H₂₆ClN₇O₃

Colore e forma: Neat

Peso molecolare: 483.95

Ref: 86-MM3313.00

Avanafil

CAS: 330784-47-9

Formula: C₂₃H₂₆ClN₇O₃

Colore e forma: Neat

Peso molecolare: 483.95

Ref: 04-C10333900

Avanafil

CAS: 330784-47-9

Avanafil (TA1790) is a selective inhibitor of phosphodiesterase type 5 (PDE5) and is used as therapy of erectile dysfunction.

Formula: C₂₃H₂₆ClN₇O₃

Purezza: 99.03% - >99.99%

Colore e forma: White Solid

Peso molecolare: 483.95

Ref: TM-T2334

Avanafil-d5

CAS: 330784-47-9

Formula: C₂₃H₂₁D₅ClN₇O₃

Peso molecolare: 488.99

Ref: 4Z-A-2968

Avanafil Impurity 15

CAS: 330784-47-9

Formula: C₂₄H₂₄ClN₇O₄

Peso molecolare: 509.96

Ref: 4Z-A-2923

Avanafil

CAS: 330784-47-9

Formula: C₂₃H₂₆ClN₇O₃

Purezza: ≥ 98.0% (dried basis)

Colore e forma: White to off-white crystalline powder

Peso molecolare: 483.95

Ref: 7W-GX0016

Aucubin Impurity 1

CAS: 330784-47-9

Formula: C₂₇H₃₄O₁₅

Peso molecolare: 598.55

Ref: 4Z-A-291002

Avanafil

Prodotto controllato

CAS: 330784-47-9

Applications A phosphodiesterase (PDE5) inhibitor, used to treat erectile dysfunction.
References Hatzimouratidis, K., et al.: Drugs, 68, 231 (2008);

Formula: C₂₃H₂₆ClN₇O₃

Colore e forma: White

Peso molecolare: 483.95

Ref: TR-A794670

Avanafil - Bio-X ™

CAS: 330784-47-9

Avanafil is a phosphodiesterase-5 (PDE5) inhibitor drug that can be used as a treatment for male erectile dysfunction. It works by inhibiting the production of PDE5, which is an enzyme that regulates the levels of cGMP in the penis. Elevated levels of cGMP, results in an increase of blood flow to the penis.

Formula: C₂₃H₂₆ClN₇O₃

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 483.95 g/mol

Ref: 3D-BC300048

Avanafil

CAS: 330784-47-9

Avanafil is a drug that can be used as a treatment for male erectile dysfunction. It works by inhibiting the production of PDE5, which is an enzyme that regulates the levels of cGMP in the penis. Avanafil has been shown to be effective when taken at a dose of 100 mg; this is because it takes about 30 minutes for avanafil to reach its peak level. Avanafil has a chemical stability that is greater than 12 hours, with an average lifespan of 24 hours. The drug also has no major drug interactions and does not inhibit any other drugs from working.

Formula: C₂₃H₂₆ClN₇O₃

Purezza: Min. 98 Area-%

Colore e forma: White Powder

Peso molecolare: 483.95 g/mol

Ref: 3D-FC18033

Avanafil-13C-d3

Prodotto controllato

CAS: 330784-47-9

Formula: CC₂₃D₃H₂₅ClN₇O₂

Colore e forma: Neat

Peso molecolare: 485.989

Ref: TR-A794674

Avanafil-d5

Prodotto controllato

CAS: 330784-47-9

Applications Unlabeled compound, Avanafil (A794670), is a phosphodiesterase (PDE5) inhibitor, used to treat erectile dysfunction.
References Hatzimouratidis, K., et al.: Drugs, 68, 231 (2008);

Formula: C₂₃H₂₁D₅ClN₇O₃

Colore e forma: Neat

Peso molecolare: 488.98

Ref: TR-A794673