CAS 33279-57-1

k-Strofantoside

Descrizione:

k-Strofantoside, con il numero CAS 33279-57-1, è un glicoside cardiaco derivato dai semi del genere Strophanthus, in particolare da Strophanthus gratus. È caratterizzato dalla sua capacità di inibire l'enzima Na+/K+ ATPasi, il che porta a un aumento delle concentrazioni intracellulari di sodio e calcio, migliorando infine la contrattilità cardiaca. Questo composto presenta una struttura che include un nucleo steroideo con un gruppo zuccherino, contribuendo alla sua attività biologica. k-Strofantoside è noto per le sue potenziali applicazioni terapeutiche nel trattamento di condizioni cardiache, in particolare insufficienza cardiaca e aritmie, grazie ai suoi effetti inotropi positivi. Tuttavia, ha anche una finestra terapeutica ristretta, richiedendo un attento monitoraggio del dosaggio per evitare tossicità. La sostanza è tipicamente somministrata in un ambiente medico controllato e la sua farmacocinetica può essere influenzata da vari fattori, comprese variabili specifiche del paziente e farmaci concomitanti. Come con altri glicosidi cardiaci, è essenziale considerare i potenziali effetti collaterali, come disturbi gastrointestinali e aritmie, quando si valuta il suo uso nella pratica clinica.

Formula: C₄₂H₆₄O₁₉

InChI: InChI=1/C42H64O19/c1-19-36(61-38-35(51)33(49)31(47)27(60-38)17-56-37-34(50)32(48)30(46)26(15-43)59-37)25(54-3)13-29(57-19)58-21-4-9-40(18-44)23-5-8-39(2)22(20-12-28(45)55-16-20)7-11-42(39,53)24(23)6-10-41(40,52)14-21/h12,18-19,21-27,29-38,43,46-53H,4-11,13-17H2,1-3H3/t19-,21+,22?,23+,24-,25+,26-,27-,29+,30-,31-,32+,33+,34-,35-,36-,37-,38+,39-,40+,41+,42+/m1/s1

InChI key: InChIKey=GILGYKHFZXQALF-FBPIOBPTSA-N

SMILES: C(=O)[C@@]12[C@@]3([C@]([C@]4(O)[C@](C)(CC3)[C@H](CC4)C=5COC(=O)C5)(CC[C@]1(O)C[C@@H](O[C@H]6C[C@H](OC)[C@H](O[C@@H]7O[C@H](CO[C@@H]8O[C@H](CO)[C@@H](O)[C@H](O)[C@H]8O)[C@@H](O)[C@H](O)[C@H]7O)[C@@H](C)O6)CC2)[H])[H]

Sinonimi:

• (3beta,5beta)-3-((O-beta-D-glucopyranosyl-(1.6)-O-beta-D-glucopyranosyl-(1.4)-2,6-dideoxy-3-O-methyl-beta-D-ribo-hexopyranosyl)oxy)-5,14-dihydroxy-19-oxocard-20(22)-enolide
• (3beta,5beta,17xi)-3-{[beta-D-glucopyranosyl-(1->6)-beta-D-glucopyranosyl-(1->4)-2,6-dideoxy-3-O-methyl-beta-D-ribo-hexopyranosyl]oxy}-5,14-dihydroxy-19-oxocard-20(22)-enolide
• (3β,5β)-3-[(O-β-<span class="text-smallcaps">D</smallcap>-Glucopyranosyl-(1→6)-O-β-<smallcap>D</smallcap>-glucopyranosyl-(1→4)-2,6-dideoxy-3-O-methyl-β-<smallcap>D</span>-ribo-hexopyranosyl)oxy]-5,14-dihydroxy-19-oxocard-20(22)-enolide
• 3-{[hexopyranosyl-(1->6)hexopyranosyl-(1->4)-2,6-dideoxy-3-O-methylhexopyranosyl]oxy}-5,14-dihydroxy-19-oxocard-20(22)-enolide
• 5-beta-Card-20(22)-enolide, 3-beta-((O-beta-D-glucopyranosyl-(1-6)-O-beta-D-glucopyranosyl-(1-4)-2,6-dideoxy-3-O-methyl-beta-D-ribo-hexopyranosyl)oxy)-5,14-dihydroxy-19-oxo-
• Card-20(22)-enolide, 3-((O-beta-D-glucopyranosyl-(1-6)-O-beta-D-glucopyranosyl-(1-4)-2,6-dideoxy-3-O-methyl-beta-D-ribo-hexopyranosyl)oxy)-5,14-dihydroxy-19-oxo-, (3beta,5beta)- (9CI)
• Card-20(22)-enolide, 3-[(O-β-<span class="text-smallcaps">D</smallcap>-glucopyranosyl-(1→6)-O-β-<smallcap>D</smallcap>-glucopyranosyl-(1→4)-2,6-dideoxy-3-O-methyl-β-<smallcap>D</span>-ribo-hexopyranosyl)oxy]-5,14-dihydroxy-19-oxo-, (3β,5β)-
• Nsc 7530
• Strophanthidin + cymarose + beta-glucose + alpha-glucose
• Strophanthidin + cymarose + beta-glucose + alpha-glucose [German]
• Strophanthoside-K
• k-Strofantozyd
• k-Strofantozyd [Polish]
• k-Strophanthidin-gamma
• k-Strophanthoside
• k-Strophantosid
• k-Strophantosid [German]
• k-Strophantoside
• (3β,5β)-3-[(O-β-D-Glucopyranosyl-(1→6)-O-β-D-glucopyranosyl-(1→4)-2,6-dideoxy-3-O-methyl-β-D-ribo-hexopyranosyl)oxy]-5,14-dihydroxy-19-oxocard-20(22)-enolide
• Card-20(22)-enolide, 3-[(O-β-D-glucopyranosyl-(1→6)-O-β-D-glucopyranosyl-(1→4)-2,6-dideoxy-3-O-methyl-β-D-ribo-hexopyranosyl)oxy]-5,14-dihydroxy-19-oxo-, (3β,5β)-
• copyranosyl-(1-4)-2,6-dideoxy-3-o-methyl-beta-d-ribo-hexopyranosyl)oxy)-5,14-d
• K-strophanthin variable mixture
• 3β-[4-O-[6-O-(β-D-Glucopyranosyl)-β-D-glucopyranosyl]-2,6-dideoxy-3-O-methyl-β-D-ribo-hexopyranosyloxy]-5,14-dihydroxy-19-oxo-5β-card-20(22)-enolide
• STROPHANTHOSIDE, K-(RG)
• Strophanthosid-K
• ihydroxy-19-oxo-

K-Strophanthoside

CAS: 33279-57-1

K-Strophanthoside analytical standard provided with chromatographic purity, to be used as reference material for qualitative determination.

Formula: C₄₂H₆₄O₁₉

Purezza: (HPLC) ≥90%

Colore e forma: Powder

Peso molecolare: 872.96

Ref: 11-0858

K-strophanthoside

CAS: 33279-57-1

Natural glycoside

Formula: C₄₂H₆₄O₁₉

Purezza: ≥ 90.0 % (HPLC)

Colore e forma: Powder

Peso molecolare: 872.96

Ref: 5G-82206

K-Strophanthoside

CAS: 33279-57-1

K-Strophanthoside is a cardiac glycoside, which is a bioactive compound derived from the seeds of certain Strophanthus species, a genus of plants native to Africa. This compound exhibits its mode of action by inhibiting the sodium-potassium ATPase enzyme on cell membranes, leading to an increase in intracellular sodium levels. Consequently, the sodium-calcium exchanger is affected, resulting in elevated intracellular calcium concentrations. This cascade enhances cardiac contractility, which can be beneficial in treating certain types of heart failure.

Formula: C₄₂H₆₄O₁₉

Purezza: Min. 95%

Peso molecolare: 872.9 g/mol

Ref: 3D-IBA27957

k-Strophanthoside

CAS: 33279-57-1

k-Strophanthoside is a natural product for research related to life sciences. The catalog number is TN4362 and the CAS number is 33279-57-1.

Formula: C₄₂H₆₄O₁₉

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 872.95

Ref: TM-TN4362