CAS 33419-42-0: Etoposide

Descrizione: Etoposide è un agente chemioterapico utilizzato principalmente nel trattamento di vari tipi di cancro, incluso il cancro testicolare e il cancro polmonare a piccole cellule. È classificato come un inibitore della topoisomerasi II, il che significa che interferisce con l'enzima responsabile della replicazione e riparazione del DNA, portando infine alla morte delle cellule tumorali. Etoposide viene tipicamente somministrato per via endovenosa o orale ed è noto per la sua efficacia in combinazione con altri farmaci chemioterapici. Il composto ha una formula molecolare di C21H22O8 e un peso molecolare di circa 366,39 g/mol. Etoposide è caratterizzato dalla sua capacità di indurre apoptosi nelle cellule tumorali, rendendolo uno strumento prezioso in oncologia. Tuttavia, può anche causare effetti collaterali, tra cui mielosoppressione, disturbi gastrointestinali e un aumento del rischio di malignità secondarie. A causa del suo meccanismo d'azione, un attento monitoraggio e gestione del dosaggio sono essenziali per minimizzare la tossicità massimizzando l'efficacia terapeutica. In generale, Etoposide rimane un agente importante nell'arsenale contro alcune malignità.

Formula: C₂₉H₃₂O₁₃

InChI: InChI=1S/C29H32O13/c1-11-36-9-20-27(40-11)24(31)25(32)29(41-20)42-26-14-7-17-16(38-10-39-17)6-13(14)21(22-15(26)8-37-28(22)33)12-4-18(34-2)23(30)19(5-12)35-3/h4-7,11,15,20-22,24-27,29-32H,8-10H2,1-3H3/t11-,15+,20-,21-,22+,24-,25-,26-,27-,29+/m1/s1

InChI key: InChIKey=VJJPUSNTGOMMGY-MRVIYFEKSA-N

SMILES: O=C1OCC2C(OC3OC4COC(OC4C(O)C3O)C)C5=CC=6OCOC6C=C5C(C7=CC(OC)=C(O)C(OC)=C7)C12

Sinonimi:

• (5R,5aR,8aR,9S)-9-[[4,6-O-(1R)-Ethylidene-β-<span class="text-smallcaps">D</span>-glucopyranosyl]oxy]-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one
• (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl 4,6-O-[(1R)-ethylidene]-alpha-L-gulopyranoside
• (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl 4,6-O-[(1R)-ethylidene]-beta-D-mannopyranoside
• (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl 4,6-O-[(1S)-ethylidene]-alpha-L-gulopyranoside
• (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl 4,6-O-[(1S)-ethylidene]-beta-D-mannopyranoside
• (8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl 4,6-O-[(1R)-ethylidene]-beta-D-glucopyranoside
• 4'-Demethyl-1-O-[4,6-O-(ethylidene)-β-D-glucopyranosyl]epipodophyllotoxin
• 4'-Demethylepipodophyllotoxin 9-(4,6-O-ethylidene-β-D-glucopyranoside)
• 4'-Demethylepipodophyllotoxin ethylidene-β-D-glucoside
• 4'-Demethylepipodophyllotoxin-(4,6-O-(R)-Ethylidene-Beta-D-Glucopyranoside)
• 4-Demethylepipodophyllotoxin-Beta-D-Ethylideneglucoside
• 4′-Demethyl-1-O-[4,6-O-(ethylidene)-β-<span class="text-smallcaps">D</span>-glucopyranosyl]epipodophyllotoxin
• 4′-Demethylepipodophyllotoxin 9-(4,6-O-ethylidene-β-<span class="text-smallcaps">D</span>-glucopyranoside)
• 4′-Demethylepipodophyllotoxin ethylidene-β-<span class="text-smallcaps">D</span>-glucoside
• Beposid
• Bioposide
• Celltop
• EPE
• Epipodophyllotoxin VP 16213
• Epipodophyllotoxin, 4'-demethyl-, 4,6-O-ethylidene-β-D-glucopyranoside
• Epipodophyllotoxin, 4′-demethyl-, 4,6-O-ethylidene-β-<span class="text-smallcaps">D</span>-glucopyranoside
• Eposed
• Eposin
• Ethopul
• Eto-Gry
• Etoposid
• Etoposido
• Etosid
• Furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 9-[(4,6-O-ethylidene-β-D-glucopyranosyl)oxy]-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-, [5R-[5α,5aβ,8aα,9β(R*)]]-
• Furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 9-[[4,6-O-(1R)-ethylidene-β-D-glucopyranosyl]oxy]-5,8,8a,9-tetrahy dro-5-(4-hydroxy-3,5-dimethoxyphenyl)-, (5R,5aR,8aR,9S)-
• Furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 9-[[4,6-O-(1R)-ethylidene-β-D-glucopyranosyl]oxy]-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-, (5R,5aR,8aR,9S)-
• Furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 9-[(4,6-O-ethylidene-β-<span class="text-smallcaps">D</span>-glucopyranosyl)oxy]-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-, [5R-[5α,5aβ,8aα,9β(R*)]]-
• Furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 9-[[4,6-O-(1R)-ethylidene-β-<span class="text-smallcaps">D</span>-glucopyranosyl]oxy]-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-, (5R,5aR,8aR,9S)-
• Fytop
• Fytosid
• Lastet
• Nsc 141540
• Nzytop
• Pyrano[3,2-d]-1,3-dioxin, furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one deriv.
• Sintopozid
• Topok
• Toposar
• Toposide
• VP 16 (pharmaceutical)
• VePesid
• Vepesid J
• Vp 16
• Vp 16-123
• Vp 16-213
• Zuyeyidal
• trans-Etoposide
• Furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 9-[(4,6-O-ethylidene-β-D-glucopyranosyl)oxy]-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-, [5R-[5α,5aβ,8aα,9β(R*)]]-
• (5R,5aR,8aR,9S)-9-[[4,6-O-(1R)-Ethylidene-β-D-glucopyranosyl]oxy]-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one
• Furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 9-[[4,6-O-(1R)-ethylidene-β-D-glucopyranosyl]oxy]-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-, (5R,5aR,8aR,9S)-

Etoposide

CAS: 33419-42-0

• Formula: C₂₉H₃₂O₁₃
• Purezza: >98.0%(HPLC)
• Colore e forma: White to Almost white powder to crystal
• Peso molecolare: 588.56

Etoposide

CAS: 33419-42-0

Etoposide is used as a inhibits DNA synthesis and is very active against cells in …

• Formula: C₂₉H₃₂O₁₃
• Colore e forma: Powder or crystals or crystalline powder
• Peso molecolare: 588.56

Etoposide for system suitability CRS

CAS: 33419-42-0

• Formula: C₂₉H₃₂O₁₃
• Peso molecolare: 588.5566

Etoposide CRS

CAS: 33419-42-0

• Formula: C₂₉H₃₂O₁₃
• Colore e forma: Crystalline Powder. White. Powder.
• Peso molecolare: 588.5566

Etoposide

CAS: 33419-42-0

Other glycosides, natural or reproduced by synthesis, and their salts, ethers, esters and other derivatives

• Formula: C₂₉H₃₂O₁₃
• Colore e forma: White Off-White Powder
• Peso molecolare: 588.18429

Etoposide

CAS: 33419-42-0

Etoposide (VP-16-213) is a topoisomerase II inhibitor that inhibits DNA synthesis by forming a complex …

• Formula: C₂₉H₃₂O₁₃
• Purezza: 99.19% - 99.94%
• Colore e forma: Crystals From Methanol Solid
• Peso molecolare: 588.56

(5R,5aR,8aR,9S)-9-[[4,6-O-(1R)-Ethylidene-β-D-glucopyranosyl]oxy]-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one

CAS: 33419-42-0

• Formula: C₂₉H₃₂O₁₃
• Purezza: 98%
• Colore e forma: Solid
• Peso molecolare: 588.5566

Etoposide

CAS: 33419-42-0

• Formula: C₂₉H₃₂O₁₃
• Purezza: (HPLC) ≥ 98.0%
• Colore e forma: White or almost white crystalline powder
• Peso molecolare: 588.56

Etoposide, USP grade

CAS: 33419-42-0

• Formula: C₂₉H₃₂O₁₃
• Purezza: (anhydrous basis) 95.0 - 105.0 %
• Colore e forma: White or almost white crystalline powder
• Peso molecolare: 588.56

Etoposide-13C-d3

CAS: 33419-42-0

• Formula: C₂₈₁₃CH₂₉D₃O₁₃
• Colore e forma: Off-White Solid
• Peso molecolare: 592.57

Etoposide

CAS: 33419-42-0

• Formula: C₂₉H₃₂O₁₃
• Colore e forma: Neat
• Peso molecolare: 588.56

Etoposide

CAS: 33419-42-0

Etoposide is a chemotherapy medication used for the treatments of a number of types of …

• Formula: C₂₉H₃₂O₁₃
• Purezza: 95%~99%
• Peso molecolare: 588.562

Etoposide

CAS: 33419-42-0

• Formula: C₂₉H₃₂O₁₃
• Colore e forma: Neat
• Peso molecolare: 588.56

Etoposide

CAS: 33419-42-0

• Formula: C₂₉H₃₂O₁₃
• Colore e forma: White To Off-White Solid
• Peso molecolare: 588.56

Etoposide

CAS: 33419-42-0

• Formula: C₂₉H₃₂O₁₃
• Purezza: By hplc: 99.51% by area. (Typical Value in Batch COA)
• Colore e forma: pale yellow solid
• Peso molecolare: 588.56g/mol

Etoposide RS

CAS: 33419-42-0

• Colore e forma: White

Etoposide-d3

CAS: 33419-42-0

Applications A labelled DNA topoisomerase II inhibitor. Semi-synthetic derivative of podophyllotoxin, related structurally to Teniposide. …

• Formula: C₂₉H₂₉D₃O₁₃
• Colore e forma: Neat
• Peso molecolare: 591.58

Etoposide-d4

CAS: 33419-42-0

Applications Etoposide-d4, is the labeled analogue of Etoposide (E933750), a DNA topoisomerase II inhibitor. Semi-synthetic …

• Formula: C₂₉H₂₈D₄O₁₃
• Colore e forma: Neat
• Peso molecolare: 592.58

Etoposide

CAS: 33419-42-0

• Formula: C₂₉H₃₂O₁₃
• Colore e forma: Off-White
• Peso molecolare: 588.56

Etoposide

CAS: 33419-42-0

Etoposide is a cytotoxic drug used in cancer chemotherapy. It inhibits DNA replication through inhibition …

• Formula: C₂₉H₃₂O₁₃
• Purezza: Min. 98 Area-%
• Colore e forma: White Powder
• Peso molecolare: 588.55 g/mol