CAS 339990-02-2

L-a-Asparagina, N-acetil-L-leucil-L-prolil-L-fenilalanil-L-fenilalanil-

Descrizione:

La L-a-Asparagina, N-acetil-L-leucil-L-prolil-L-fenilalanina-L-fenilalanina, identificata dal numero CAS 339990-02-2, è un peptide sintetico che consiste in una sequenza di amminoacidi, tra cui asparagina, leucina, prolina e fenilalanina. Questo composto è caratterizzato dal suo specifico arrangiamento di questi amminoacidi, che contribuisce alle sue proprietà uniche e alle potenziali attività biologiche. I peptidi come questo spesso mostrano varie funzioni nei sistemi biologici, inclusi ruoli nella segnalazione, attività enzimatica e supporto strutturale. La modifica N-acetil tipicamente migliora la stabilità e la solubilità del peptide, rendendolo più adatto per varie applicazioni nella ricerca e nella farmacologia. Inoltre, la presenza di amminoacidi aromatici, come la fenilalanina, può influenzare le interazioni del peptide con altre biomolecole. In generale, questo composto rappresenta una struttura complessa che può essere di interesse negli studi relativi alla biochimica, farmacologia e sintesi di peptidi.

Formula: C₃₅H₄₆N₆O₈

Sinonimi:

• 10:PN: WO03050139 SEQID: 15 claimed protein
• 3: PN: WO0134631 PAGE: 35 claimedprotein
• As 602704
• Ac-Leu-Pro-Phe-Phe-Asp-Nh2

Acetyl-(Pro¹⁸,Asp²¹)-Amyloid β-Protein (17-21) amide

CAS: 339990-02-2

The pentapeptide Ac-LPFFD-NH₂ (iAβ5p) is an analog of product H-4876 with small chemical modifications which enhance its stability against proteolytic degradation. iAβ5p acts as a β-sheet breaker peptide and crosses the blood-brain barrier at a higher rate than most proteins and peptides known to be selectively taken up by the brain so that it is assumed that the peptide is being specifically transported to the brain. A significant increase in neuronal survival and decrease in brain inflammation associated with the reduction of amyloid plaques in two different transgenic Alzheimer`s disease (AD) models is additionally reported for iAβ5p.

Formula: C₃₅H₄₆N₆O₈

Purezza: > 95%

Colore e forma: White Powder

Peso molecolare: 678.79

Ref: 01-4045708

Ac-Leu-Pro-Phe-Phe-Asp-NH2

CAS: 339990-02-2

Ac-Leu-Pro-Phe-Phe-Asp-NH2 is a potential therapeutic for Alzheimer's disease. It has been shown to reduce the production of reactive oxygen species and inhibit the formation of amyloid beta oligomers. Ac-Leu-Pro-Phe-Phe-Asp-NH2 also reduces the frequency of protofibrils, which are aggregates that may play a role in Alzheimer's disease pathology. This peptide has been shown to have a protective effect on cell populations, which may lead to therapeutics that can delay or prevent Alzheimer's disease. Ac-Leu-Pro-Phe-Phe-Asp NH2 is an inhibitor of amyloid beta peptides and modulates their aggregation into protofibrils.

Formula: C₃₅H₄₆N₆O₈

Purezza: Min. 95%

Peso molecolare: 678.89 g/mol

Ref: 3D-PAB-3632-PI

Acetyl-(Pro18,Asp21)-Amyloid b-Protein (17-21) amide

CAS: 339990-02-2

Acetyl-(Pro18,Asp21)-Amyloid b-Protein (17-21) amide is a peptide that was generated by incubating β-amyloid with the protease papain. This peptide has been shown to induce population and biochemical changes in cells, including focusing of β-amyloid aggregates. It also induces reactive oxygen species and promotes extracellular protofibril formation. Acetyl-(Pro18,Asp21)-Amyloid b-Protein (17-21) amide is a conjugate of acetylated lysine residues and amyloid β-protein that can be used as an anti-amyloid therapeutic. The peptide is characterized by dichroism spectroscopy, which has revealed its specific binding to the fibrils' surface.

Formula: C₃₅H₄₆N₆O₈

Purezza: Min. 95%

Peso molecolare: 678.78 g/mol

Ref: 3D-FA109732