CAS 342790-21-0

L-Treonina, L-a-aspartil-L-treonil-L-istidil-L-fenilalanil-L-prolil-L-isoleucil-L-cisteinil-L-isoleucil-L-fenilalanil-L-cisteinil-L-cisteinilglicil-L-cisteinil-L-cisteinil-L-istidil-L-arginil-L-seril-L-lisil-L-cisteinilglicil-L-metionil-L-cisteinil

Descrizione:

La sostanza a cui ti riferisci, con il nome "L-Treonina, L-a-aspartil-L-treonil-L-istidil-L-fenilalanina-L-prolina-L-isoleucina-L-cisteina-L-isoleucina-L-fenilalanina-L-cisteina-L-cisteina-L-cisteina-L-istidil-L-arginina-L-serina-L-lisina-L-glicina-L-metionina-L-cisteina" e numero CAS "342790-21-0", è un peptide complesso composto da più aminoacidi. Questa sostanza è caratterizzata dalla sua sequenza di L-aminoacidi, che sono i mattoni delle proteine. La presenza di vari aminoacidi, tra cui treonina, acido aspartico, istidina, fenilalanina, prolina, isoleucina, cisteina, arginina, serina, lisina e metionina, suggerisce che possa avere diverse funzioni biologiche e potenziali applicazioni in biochimica e medicina. La struttura del peptide probabilmente influisce sulla sua solubilità, stabilità e interazione con i sistemi biologici. Inoltre, la presenza di residui di cisteina indica potenziale per la formazione di legami disolfuro, che possono influenzare la conformazione tridimensionale e la funzionalità del peptide. In generale, questa sostanza potrebbe essere di interesse nella ricerca relativa alla sintesi proteica, all'attività enzimatica e allo sviluppo terapeutico.

Formula: C₁₁₃H₁₇₀N₃₄O₃₁S₉

Sinonimi:

• HepcidinHepc25 (human)
• Hepcidin-25 (human)
• Hepcidin-25
• H-Asp-Thr-His-Phe-Pro-Ile-Cys-Ile-Phe-Cys-Cys-Gly-Cys-Cys-His-Arg-Ser-Lys-Cys-Gly-Met-Cys-Cys-Lys-Thr-Oh

Hepcidin / LEAP-1

CAS: 342790-21-0

Hepcidin, also known as LEAP-1 (liver-expressed antimicrobial peptide) or Hepcidin-25 is a hormone of 25 amino acids.
Hepcidin is a cationic, cysteine-rich and tightly folded peptide stabilized by 4 disulfide bonds that plays a major role in innate immunity and iron homeostasis.
Hepcidin inhibits iron transport by binding to the iron export channel ferroportin which is located on the basolateral surface of gut enterocytes and the plasma membrane of reticuloendothelial cells (macrophages). Hepcidin breaks down the transporter protein in the lysosome. Inhibiting ferroportin prevents iron exportation and iron is retained in cells.
Hepcidin is regulated by iron through a complex of integral hemochromatosis proteins, like HFE, HJV and transferrin receptor 2.
Hepcidin is also characterized by is antimicrobial activity in several vertebrate species, exerting its antimicrobial effect against both Gram-positive and Gram-negative bacteria as well as yeast, with for example an IC50 value against Saccharomyces cerevisae of 18 µM.

Formula: C₁₁₃H₁₇₀N₃₄O₃₁S₉

Purezza: Min. 95%

Peso molecolare: 2,789.4 g/mol

Ref: 3D-PLP-4392-S

Hepcidin/LEAP-1 (Human) (Bulk)

CAS: 342790-21-0

Human Hepcidin peptide hormone product also know as LEAP-1 (liver-expressed antimicrobial peptide), where the disulfides are formed by random oxidation. Hepcidin is a peptide hormone that is synthesized in the liver and is an important regulator of iron homeostasis. Through binding to ferroportin Hepcidin prevents the exportation of iron thus reducing the amount of circulating iron. Furthermore through inflammatory cytokine induction Hepcidin leads to the internalization and degradation of ferroportin thus further reducing the amount of iron in circulation. This in turn make conditions unfavourable to invading pathogens. This demonstrates Hepcidin's ability as an anti-microbial peptide. This antimicrobial behaviour can be used in research into the elimination of pathogens but also in combatting diseases where iron dysregulation is prevalant.

Formula: C₁₁₃H₁₇₀N₃₄O₃₁S₉

Purezza: Min. 95%

Peso molecolare: 2,789.4 g/mol

Ref: 3D-PLP-3771-PI