CAS 3432-99-3

Acido 5,10-metilene-5,6,7,8-tetraidrofolico

Descrizione:

Acido 5,10-metilene-5,6,7,8-tetraidrofolico, comunemente noto come metilentetraidrofolato, è un derivato del folato, una vitamina B essenziale per vari processi biologici. Questo composto gioca un ruolo cruciale nel metabolismo del carbonio, in particolare nella sintesi di nucleotidi e aminoacidi, che sono vitali per la replicazione e riparazione del DNA. È caratterizzato dalla sua struttura di tetraidrofolato, che include un anello di pteridina, acido para-aminobenzoico e una coda di acido glutammico. Il gruppo metilenico nella posizione 5,10 è significativo per la sua funzione nel trasferimento di unità di carbonio. Questo composto è solubile in acqua ed è tipicamente coinvolto in reazioni enzimatiche catalizzate dalla metilentetraidrofolato reduttasi (MTHFR). Le carenze in questo composto possono portare a vari problemi di salute, tra cui anemia megaloblastica e livelli elevati di omocisteina, che sono associati a malattie cardiovascolari. Il suo ruolo nel metabolismo cellulare e il suo coinvolgimento nel ciclo di metilazione sottolineano la sua importanza nella salute e nutrizione umana.

Formula: C₂₀H₂₃N₇O₆

InChI: InChI=1/C20H23N7O6/c21-20-24-16-15(18(31)25-20)27-9-26(8-12(27)7-22-16)11-3-1-10(2-4-11)17(30)23-13(19(32)33)5-6-14(28)29/h1-4,12-13H,5-9H2,(H,23,30)(H,28,29)(H,32,33)(H4,21,22,24,25,31)/t12?,13-/m0/s1

InChI key: InChIKey=QYNUQALWYRSVHF-ABLWVSNPSA-N

SMILES: O=C1C=2N3C(CN(C3)C4=CC=C(C(N[C@@H](CCC(O)=O)C(O)=O)=O)C=C4)(CNC2NC(N)=N1)[H]

Sinonimi:

• (+)-5,10-Methylene-5,6,7,8-tetrahydrofolic acid
• (2s)-2-(4-(3-Amino-1-oxo-5,6,6a,7-tetrahydroimidazo[1,5-f]pteridin-8(1H,4H,9H)-yl)benzamido)pentanedioic acid
• 5,10-Methylene-(6RS)-tetrahydrofolic acid
• 5,10-Methylenetetrafolate
• 5,10-Methylenetetrahydrofolic acid
• <span class="text-smallcaps">L</span>-Glutamic acid, N-[4-(3-amino-1,2,5,6,6a,7-hexahydro-1-oxoimidazo[1,5-f]pteridin-8(9H)-yl)benzoyl]-
• Anx-510
• Folic acid, tetrahydro-N⁵,N¹⁰-methylene-
• Folitixorin
• Glutamic acid, N-[p-(3-amino-5,6,6a,7-tetrahydro-1-hydroxyimidazo[1,5-f]pteridin-8(9H)-yl)benzoyl]-, <span class="text-smallcaps">L</span>-
• Imidazo[1,5-f]pteridine, <span class="text-smallcaps">L</span>-glutamic acid deriv.
• L-glutamic acid, N-[4-(3-amino-5,6,6a,7-tetrahydro-1-hydroxyimidazo[1,5-f]pteridin-8(9H)-yl)benzoyl]-
• N-[4-(3-Amino-1,2,5,6,6a,7-hexahydro-1-oxoimidazo[1,5-f]pteridin-8(9H)-yl)benzoyl]-<span class="text-smallcaps">L</span>-glutamic acid
• N-[4-(3-amino-1-hydroxy-5,6,6a,7-tetrahydroimidazo[1,5-f]pteridin-8(9H)-yl)benzoyl]-L-glutamic acid
• N-{4-[(6aR)-3-amino-1-oxo-1,4,5,6,6a,7-hexahydroimidazo[1,5-f]pteridin-8(9H)-yl]benzoyl}-L-glutamic acid
• N⁵,N¹⁰-Methylene-5,6,7,8-tetrahydrofolic acid
• N⁵,N¹⁰-Methylenetetrahydrofolic acid
• N⁵,N¹⁰-Methylenetetrahydropteroylglutamic acid
• Imidazo[1,5-f]pteridine, L-glutamic acid deriv.
• Folic acid, tetrahydro-N5,N10-methylene-
• Glutamic acid, N-[p-(3-amino-5,6,6a,7-tetrahydro-1-hydroxyimidazo[1,5-f]pteridin-8(9H)-yl)benzoyl]-, L-
• L-Glutamic acid, N-[4-(3-amino-1,2,5,6,6a,7-hexahydro-1-oxoimidazo[1,5-f]pteridin-8(9H)-yl)benzoyl]-
• N-[4-(3-Amino-1,2,5,6,6a,7-hexahydro-1-oxoimidazo[1,5-f]pteridin-8(9H)-yl)benzoyl]-L-glutamic acid
• 5,10-METHYLENETETRAHYDROFOLICACID
• N5,N10-Methyl-
• N5,N10-MethylenetetrahydropteroylglutaMic Acid
• Levofolinate Methylene Impurity
• enetetrahydrofolic Acid
• N-[4-[(3-Amino-1,2,5,6,6a,7,8,9-octahydro-1-oxoimidazo[1,5-f]pteridin)-8-yl]benzoyl]-L-glutamic acid
• (Mixture of Diastereomers)
• Folic Acid Impurity 13 Monomer
• Folitixorin (~80%)

5,10-METHYLENETETRAHYDROFOLATE

CAS: 3432-99-3

Formula: C₂₀H₂₃N₇O₆

Purezza: 95%

Colore e forma: Solid

Peso molecolare: 457.4399

Ref: IN-DA00C95H

(2S)-2-(4-(3-Amino-1-oxo-1,2,5,6,6a,7-hexahydroimidazo[1,5-f]pteridin-8(9H)-yl)benzamido)pentanedioic acid

CAS: 3432-99-3

(2S)-2-(4-(3-Amino-1-oxo-1,2,5,6,6a,7-hexahydroimidazo[1,5-f]pteridin-8(9H)-yl)benzamido)pentanedioic acid

Purezza: 95%

Peso molecolare: 457.45g/mol

Ref: 54-OR1053159

Calcium Folinate EP Impurity I (Folitixorin) (Mixture of Diastereomers)

CAS: 3432-99-3

Formula: C₂₀H₂₃N₇O₆

Peso molecolare: 457.45

Ref: 4Z-C-466006

Folitixorin (~80%)(Mixture of Diastereomers)

CAS: 3432-99-3

Stability Hygroscopic, Moisture Sensitive, Temperature Sensitive
Applications A stable folate lyophilized compound suitable for use in the treatment of cancer and other therapies.
References Park, H., et al.: Science, 268, 1866 (1995), Banerjee, R., et al.: J. Biol. Chem., 282, 14916 (2007), Klar, T., et al.: J. Mol. Biol., 366, 954 (2007),

Formula: C₂₀H₂₃N₇O₆

Colore e forma: Neat

Peso molecolare: 457.44

Ref: TR-F680350

Folitixorin-d4 Disodium Salt (>80%) (Mixture of Diastereomers)

Prodotto controllato

CAS: 133978-76-4, 3432-99-3

Formula: C₂₀H₁₇D₄N₇Na₂O₆

Colore e forma: Neat

Peso molecolare: 505.43

Ref: TR-F680352

5,10-Methylene-5,6,7,8-tetrahydrofolic acid - mixture of diastereomers

CAS: 3432-99-3

5,10-Methylene-5,6,7,8-tetrahydrofolic acid is a molecule that is found in cells. It is an essential cofactor for many biological processes. The folate form of 5,10-methylene-5,6,7,8-tetrahydrofolic acid (5MTHF) can be synthesized by the enzyme methylenetetrahydrofolate reductase. This enzyme uses N5,N10-methenyltetrahydrofolate as a substrate and converts it to 5MTHF. The enzyme activity of methylenetetrahydrofolate reductase can be inhibited by methotrexate. In this case 5MTHF will not be produced and the body's supply of folate will decrease. The structural analysis of 5MTHF has been performed using titration calorimetry and x-ray crystallography.

Formula: C₂₀H₂₃N₇O₆

Purezza: 80%Min

Colore e forma: Powder

Peso molecolare: 457.44 g/mol

Ref: 3D-FM31365

Folitixorin

CAS: 3432-99-3

Folitixorin (ANX-510) is an active folate derivative and coenzyme associated with thymidine synthesis, with potential antitumour activity.

Formula: C₂₀H₂₃N₇O₆

Purezza: 95.94%

Colore e forma: Solid

Peso molecolare: 457.44

Ref: TM-T21315

Calcium Folinate EP Impurity I

CAS: 3432-99-3

Formula: C₂₀H₂₃N₇O₆

Peso molecolare: 457.44

Ref: ST-EA-CP-C509007