CAS 34580-14-8

fumarato di ketotifene

Descrizione:

fumarato di ketotifene è un composto farmaceutico utilizzato principalmente come antistaminico e stabilizzatore dei mastociti, spesso prescritto per la gestione di condizioni allergiche come asma e rinite allergica. È un derivato del composto ketotifene, noto per la sua capacità di inibire il rilascio di istamina e altri mediatori dai mastociti. fumarato di ketotifene è tipicamente presentato come una polvere cristallina bianca a bianco sporco, solubile in acqua e con un profilo relativamente stabile in condizioni di stoccaggio standard. La forma di sale fumarato ne migliora la solubilità e la biodisponibilità. Il composto agisce bloccando i recettori H1 dell'istamina e ha proprietà antinfiammatorie aggiuntive, rendendolo efficace nella riduzione dell'iperreattività bronchiale. La sua farmacocinetica prevede somministrazione orale, con una emivita notevole che consente dosaggi una o due volte al giorno. Come per qualsiasi farmaco, gli effetti collaterali potenziali possono includere sedazione, secchezza delle fauci e disturbi gastrointestinali, richiedendo un'attenta considerazione nei pazienti con specifiche condizioni di salute.

Formula: C₂₃H₂₃NO₅S

InChI: InChI=1/C19H19NOS.C4H4O4/c1-20-9-6-13(7-10-20)18-15-5-3-2-4-14(15)12-17(21)19-16(18)8-11-22-19;5-3(6)1-2-4(7)8/h2-5,8,11H,6-7,9-10,12H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1+

InChI key: InChIKey=YNQQEYBLVYAWNX-WLHGVMLRSA-N

SMILES: O=C1C2=C(C(C=3C(C1)=CC=CC3)=C4CCN(C)CC4)C=CS2.C(=C/C(O)=O)\C(O)=O

Sinonimi:

• 1-methyl-4-(10-oxo-9,10-dihydro-4H-benzo[4,5]cyclohepta[1,2-b]thiophen-4-ylidene)piperidinium
• 10H-Benzo(4,5)cyclohepta(1,2-b)thiophen-10-one, 4,9-dihydro-4-(1-methyl-4-piperidinylidene)-, (E)-2-butenedioate (1:1)
• 10H-Benzo[4,5]cyclohepta[1,2-b]thiophen-10-one, 4,9-dihydro-4-(1-methyl-4-piperidinylidene)-, (2E)-2-butenedioate (1:1)
• 4,9-Dihydro-4-(1-methyl-4-piperidinylidene)-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-one fumarate
• 4,9-Dihydro-4-(1-methyl-4-piperidylidene)-10H-benzo(4,5)cyclohepta(1,2-b)thiophen-10-one fumarate (1:1)
• 4,9-Dihydro-4-(1-methylpiperidin-4-yliden)-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-onfumarat
• 4,9-Dihydro-4-(1-methylpiperidin-4-ylidene)-10H-benzo(4,5)cyclohepta(1,2-b)thiophene-10-one fumarate
• 4-(1-methylpiperidin-4-ylidene)-4,9-dihydro-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-one
• 4-(1-methylpiperidin-4-ylidene)-4,9-dihydro-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-one (2E)-but-2-enedioate
• Alaway
• Allerkif
• HC 20,511 fumarate
• Hc 20511
• Ketotifen fumarate [USAN:JAN]
• Ketotifen hydrogen fumarate
• Totifen
• Unii-Hbd503Woro
• Zaditen
• Zaditor
• Zasten
• fumarate de 4,9-dihydro-4-(1-methylpiperidine-4-ylidene)-10H-benzo[4,5]cyclohepta[1,2-b]thiophene-10-one
• fumarato de 4,9-dihidro-4-(1-metilpiperidin-4-ilideno)-10H-benzo[4,5]ciclohepta[1,2-b]tiofeno-10-ona
• Ketotifen fumarate
• 10h-benzo(4,5)cyclohepta(1,2-b)thiophen-10-one,4,9-dihydro-4-(1-methyl-4-pipe
• KETOTIFEN FUMARATE EP
• KETOTIFEN FUMARATE SALT
• 4-(1-methyl-4-piperidylidene)-4h-benzo[4,5]cyclohepta[1,2-b]thiophen-10(9h)-one hydrogen fumarate
• Ketotifene fumarate
• 4,9-Dihydro-4-(1-methyl-4-piperidylidene)-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-one fumarate
• Anatifen
• hc20-511fumarate

Ketotifen Fumarate

CAS: 34580-14-8

Formula: C₁₉H₁₉NOS·C₄H₄O₄

Purezza: >98.0%(T)(HPLC)

Colore e forma: White to Almost white powder to crystal

Peso molecolare: 425.50

Ref: 3B-K0048

Ketotifen fumarate, 99%

CAS: 34580-14-8

Ketotifen fumaratin is an H1 receptor antagonist. In its ophthalmic form, it is used to treat allergic conjunctivitis, or the itchy red eyes caused by allergies. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label infor

Formula: C₂₃H₂₃NO₅S

Purezza: 99%

Colore e forma: White to pale cream to pale yellow, Powder

Peso molecolare: 425.50

Ref: 02-J63708

Ketotifen Hydrogen Fumarate 1.0 mg/ml in Methanol (as free base)

CAS: 34580-14-8

Colore e forma: Single Solution

Ref: 61-AMP0180.00-01

Ketotifen Hydrogen Fumarate

CAS: 34580-14-8

Colore e forma: Neat

Ref: 61-FOR0180.00

KETOTIFEN HYDROGEN FUMARATE CRS

CAS: 34580-14-8

KETOTIFEN HYDROGEN FUMARATE CRS

Formula: C₂₃H₂₃NO₅S

Colore e forma: White. Yellow-Brown. Crystalline Powder.

Peso molecolare: 425.4974

Ref: 41-Y0001619

Ketotifen Fumarate

CAS: 34580-14-8

Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoi

Formula: C₁₉H₁₉NOS·C₄H₄O₄

Colore e forma: White Brownish Yellow Powder

Peso molecolare: 309.11874

Ref: 45-1356406

Ketotifen fumarate

CAS: 34580-14-8

Ketotifen fumarate (HC 20511 fumarate) is a cycloheptathiophene blocker of histamine H1 receptors and release of inflammatory mediators.

Formula: C₂₃H₂₃NO₅S

Purezza: 99.25% - 99.73%

Colore e forma: Solid

Peso molecolare: 425.50

Ref: TM-T0994

10H-Benzo[4,5]cyclohepta[1,2-b]thiophen-10-one, 4,9-dihydro-4-(1-methyl-4-piperidinylidene)-, (E)-2-butenedioate (1:1)

CAS: 34580-14-8

Formula: C₂₃H₂₃NO₅S

Purezza: 95%

Colore e forma: Solid

Peso molecolare: 425.4974

Ref: IN-DA003R69

Ketotifen Fumarate

CAS: 34580-14-8

Formula: C₁₉H₁₉NOS·C₄H₄O₄

Colore e forma: Off-White Solid

Peso molecolare: 309.43 116.07

Ref: 4Z-K-061

Ketotifen fumarate

CAS: 34580-14-8

Ketotifen fumarate

Purezza: ≥95%

Peso molecolare: 425.5g/mol

Ref: 54-BUP14763

Ketotifen fumarate

CAS: 34580-14-8

Ketotifen fumarate

Formula: C₁₉H₁₉NOS·C₄H₄O₄

Purezza: 99.7% (hplc) (Typical Value in Batch COA)

Colore e forma: Solid

Peso molecolare: 425.50g/mol

Ref: 54-BIK4000

Ketotifen fumarate

CAS: 34580-14-8

Formula: C₁₉H₁₉NOS·C₄H₄O₄

Purezza: ≥ 98%

Colore e forma: White to off-white powder

Peso molecolare: 425.50

Ref: 7W-GP2795

Ketotifen Hydrogen Fumarate

Prodotto controllato

CAS: 34580-14-8

Formula: C₁₉H₁₉NOS·C₄H₄O₄

Colore e forma: Neat

Peso molecolare: 425.50

Ref: 86-MM0180.00

Ketotifen Fumarate

Prodotto controllato

CAS: 34580-14-8

Applications Ketotifen is used as an antiasthmatic. Ketotifen is an antiallergic agent.
References Tsuji, F., et al.: Biol. Pharm. Bull., 33, 1050 (2010), Al O., et al.: J., Mol., Liq., 155, 103 (2010), Uccello-Barretta, G., et al.: Int. J. Pharm., 395, 122 (2010),

Formula: C₁₉H₁₉NOS·C₄H₄O₄

Colore e forma: White

Peso molecolare: 425.50

Ref: TR-K315100

Ketotifen fumarate

CAS: 34580-14-8

Ketotifen fumarate is an anti-inflammatory drug that belongs to the class of histamine H1 receptor antagonists. It has been shown to be effective in the treatment of inflammatory bowel diseases, such as Crohn’s disease and ulcerative colitis. Ketotifen fumarate also has biological properties, such as eosinophil cationic protein release inhibition, that are important for its therapeutic effects. In vitro studies have shown that ketotifen fumarate can inhibit h1-receptor mediated responses in a dose-dependent manner. The drug is metabolized by the liver enzyme CYP3A4 and has been shown to interact with other drugs metabolized through this pathway. Ketotifen fumarate is currently being used as a research tool in experimental models of infectious diseases, such as tuberculosis and influenza A virus infection.

Formula: C₂₃H₂₃NO₅S

Purezza: Min. 95%

Colore e forma: White Powder

Peso molecolare: 425.5 g/mol

Ref: 3D-FK01539