CAS 347841-46-7

Acido (3α,5β,7β)-3,7-diidrossicolan-24-oico-2,2,4,4-d4

Descrizione:

La sostanza chimica nota come "Acido (3α,5β,7β)-3,7-diidrossicolan-24-oico-2,2,4,4-d4," con il numero CAS 347841-46-7, è un derivato degli acidi biliari, specificamente una forma modificata dell'acido colico. Questo composto presenta gruppi idrossilici nelle posizioni 3 e 7 del nucleo steroideo, che sono critici per la sua attività biologica e solubilità. La presenza di deuterio (d4) indica che alcuni atomi di idrogeno nella molecola sono stati sostituiti da isotopi di deuterio, il che può essere utile negli studi di tracciamento e nella ricerca metabolica. Le modifiche strutturali contribuiscono alle sue proprietà uniche, influenzando la sua interazione con i sistemi biologici, incluso il suo ruolo nel metabolismo dei lipidi e nelle potenziali applicazioni terapeutiche. Come derivato di un acido biliare, può anche svolgere un ruolo nell'emulsificazione dei grassi e nell'aiuto alla digestione. In generale, questo composto esemplifica la complessità della chimica steroidea e le sue implicazioni nella biochimica e nella farmacologia.

Formula: C₂₄H₄₀O₄

InChI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/t14-,15+,16-,17-,18+,19+,20+,22+,23+,24-/m1/s1/i8D2,12D2

InChI key: InChIKey=RUDATBOHQWOJDD-QGCKUCIHSA-N

SMILES: C[C@@]12[C@]([C@]3([C@@]([C@]4(C)[C@](C[C@@H]3O)(C([C@H](O)C(C4)([2H])[2H])([2H])[2H])[H])(CC1)[H])[H])(CC[C@@]2([C@@H](CCC(O)=O)C)[H])[H]

Sinonimi:

• (3α,5β,7β)-3,7-Dihydroxycholan-24-oic-2,2,4,4-d₄ acid
• Cholan-24-oic-2,2,4,4-d₄ acid, 3,7-dihydroxy-, (3α,5β,7β)-
• Ursodeoxycholic-2,2,4,4-D4 Acid
• Cholan-24-oic-2,2,4,4-d4 acid, 3,7-dihydroxy-, (3α,5β,7β)-
• (3α,5β,7β)-3,7-Dihydroxycholan-24-oic-2,2,4,4-d4 acid
• Ursodeoxycholic Acid-d4 MaxSpec? Standard
• Ursodeoxycholic-d4 Acid
• URSODEOXYCHOLIC ACID (2,2,4,4-D4, 98%) 95% CHEMICAL PURITY
• Urosodeoxycholic Acid Impurity 28
• (4R)-4-[(3R,5R,7S,8R,9S,10S,13R,17R)-2,2,4,4-tetradeuterio-3,7-dihydroxy-10,13-dimethyl-3,5,6,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid
• Ursodeoxycholic acid-[d4] (Solution)
• Ursodeoxycholic Acid-2,2,4,4-d4 (Major)
• Ursodiol-d4 (Ursodeoxycholic Acid-d4)
• URSODEOXYCHOLIC ACID (2,2,4,4-D4, 98%) 100 UG/ML IN METHANOL
• (4R)-4-[(3R,5R,7S,8R,9S,10S,13R,14S,17R)-2,2,4,4-tetradeuterio-3,7-dihydroxy-10,13-dimethyl-3,5,6,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid

Ursodiol-d4 (Ursodeoxycholic Acid-d4)

CAS: 347841-46-7

Formula: C₂₄H₃₆D₄O₄

Colore e forma: White To Off-White Solid

Peso molecolare: 396.60

Ref: 4Z-U-021

Ursodeoxycholic Acid-d4

CAS: 347841-46-7

Ursodeoxycholic Acid-d4

Purezza: ≥98%

Peso molecolare: 396.6g/mol

Ref: 54-BUP01116

Ursodeoxycholic-2,2,4,4-d4Acid

CAS: 347841-46-7

Purezza: 98 atom % D

Colore e forma: White Solid

Peso molecolare: 396.60

Ref: 3U-D3819

Ursodeoxycholic Acid-d4

CAS: 347841-46-7

Ursodeoxycholic Acid-d4 (Ursodeoxycholic acid-2,2,4,4-d4) is the deuterium substituent of Ursodeoxycholic acid.

Formula: C₂₄H₄₀O₄

Purezza: 99.75%

Colore e forma: Solid

Peso molecolare: 396.6

Ref: TM-TMIH-0590

Ursodeoxycholic Acid-d4 (Major)

Prodotto controllato

CAS: 347841-46-7

Formula: C₂₄₂H₄H₃₆O₄

Colore e forma: White To Off-White

Peso molecolare: 396.60

Ref: TR-U850003

Ursodeoxycholic Acid-d4

Prodotto controllato

CAS: 347841-46-7

Applications Ursodeoxycholic Acid-d4 is a deuterated form of Ursodeoxcholic Acid (U850000), which is used as an anticholelithogenic. Ursodeoxcholic Acid is an epimer with Chenodiol with respect to the hydroxyl group at C7. Ursodeoxycholic Acid-d4 was used as an internal standard for rapid quantification of bile acids by liquid chromatography-tandem mass spectrometry.
References Tint, G.S., et al.: Gastroenterology, 91, 1007 (1986), Poupon, R.E, et al.: N. Engl. J. Med., 324, 1548 (1991), MacKenzie, P., et al.: J. Biol. Chem., 283, 36205 (2008); Scherer, M., et al.: J. Chromatogr. B, 877, 3920 (2009(

Formula: C₂₄₂H₄H₃₆O₄

Colore e forma: White To Off-White

Peso molecolare: 396.60

Ref: TR-U850007

Ursodeoxycholic acid-D4

Prodotto controllato

CAS: 347841-46-7

Ursodeoxycholic acid (UDCA) is a bile acid that belongs to the group of secondary bile acids. UDCA is used in the treatment of gallstones, primary biliary cirrhosis, and cholestatic liver diseases. UDCA is also used in the treatment of malignant tumours due to its ability to reduce cholesterol levels. Ursodeoxycholic acid-D4 has been shown to have a beneficial effect on serum cholesterol levels and has a protective effect against liver fibrosis and hepatocarcinogenesis. UDCA-D4 has been shown to be effective for the diagnosis of pancreatic cancer, hepatobiliary cancer, and bilirubin concentration. UDCA-D4 also improves the prognosis of patients with pancreatic cancer.

Formula: C₂₄H₃₆D₄O₄

Purezza: Min. 95%

Peso molecolare: 396.6 g/mol

Ref: 3D-XNA84146