CAS 357-08-4

Cloridrato di naloxone

Descrizione:

Cloridrato di naloxone è un antagonista degli oppioidi utilizzato principalmente in medicina d'emergenza per contrastare l'overdose da oppioidi. È una polvere cristallina bianca o bianco sporco solubile in acqua, rendendolo adatto per somministrazione endovenosa, intramuscolare o sottocutanea. La formula chimica di Cloridrato di naloxone è C19H21NO4•HCl e ha un peso molecolare di circa 343,84 g/mol. Questo composto agisce legandosi in modo competitivo ai recettori degli oppioidi nel sistema nervoso centrale, invertendo efficacemente gli effetti degli oppioidi, come la depressione respiratoria e la sedazione. La naloxone ha un rapido inizio d'azione, tipicamente entro pochi minuti, e i suoi effetti possono durare da 30 a 90 minuti, a seconda della dose e della via di somministrazione. È importante notare che la naloxone non è efficace contro le overdose da droghe non oppioidi e può precipitare sintomi di astinenza in individui dipendenti da oppioidi. Cloridrato di naloxone è uno strumento critico nella salute pubblica per prevenire le morti correlate agli oppioidi ed è spesso disponibile in varie formulazioni, inclusi autoiniettori e spray nasali.

Formula: C₁₉H₂₂ClNO₄

InChI: InChI=1/C19H21NO4.ClH/c1-2-8-20-9-7-18-15-11-3-4-12(21)16(15)24-17(18)13(22)5-6-19(18,23)14(20)10-11;/h2-4,14,17,21,23H,1,5-10H2;1H/t14-,17+,18+,19-;/m1./s1

InChI key: InChIKey=RGPDIGOSVORSAK-STHHAXOLSA-N

SMILES: O[C@]12[C@@]34C=5C(O[C@]3(C(=O)CC1)[H])=C(O)C=CC5C[C@]2(N(CC=C)CC4)[H].Cl

Sinonimi:

• (-)-N-Allyl-14-hydroxynordihydromorphinone hydrochloride
• (5Alpha)-3,14-Dihydroxy-17-Prop-2-En-1-Yl-4,5-Epoxymorphinan-6-One Hydrochloride
• En 1530
• En 15304
• Morphinan-6-one, 17-allyl-4,5α-epoxy-3,14-dihydroxy-, hydrochloride
• Morphinan-6-one, 4,5-epoxy-3,14-dihydroxy-17-(2-propen-1-yl)-, hydrochloride (1:1), (5α)-
• Morphinan-6-one, 4,5-epoxy-3,14-dihydroxy-17-(2-propenyl)-, hydrochloride, (5α)-
• N-Allyldihydro-14-hydroxynormorphinone hydrochloride
• Nalone
• Nalonee
• Naloxone HCl
• Narcan
• Narcanti
• Narcoxone
• Nih 7890
• Normorphinone, N-allyl-7,8-dihydro-14-hydroxy-, hydrochloride
• l-Naloxone hydrochloride
• 17-allyl-4,5-alpha-epoxy-3,14-dihydroxy-morphinan-6-onhydrochloride
• 17-allyl-4,5-alpha-epoxy-3,14-dihydroxymorphinan-6-onehydrochloride
• en1530
• (5alpha)-17-allyl-4,5-epoxy-3,14-dihydroxymorphinan-6-one hydrochloride
• 4,5alpha-epoxy-3,14-dihydroxy-17-(2-propenyl)morphinan-6-one hydrochloride
• (5ALPHA)-4,5-EPOXY-3,14-DIHYDRO-17-(2-PROPENYL)MORPHINAN-6-ONE HYDROCHLORIDE
• l-n-allyl-14-hydroxynordihydromorphinonehydrochloride
• morphinan-6-one,4,5-epoxy-3,14-dihydroxy-17-(2-propenyl)-,hydrochloride,(5-a
• NALOXONE HYDROCHLORIDE CRYSTALLINE
• NALOXONE HYDROCHLORIDE OPIOID ANTAGONIST
• nih7890
• (5a)-4,5-Epoxy-3,14-dihydroxy-17-(2-propenyl)morphinan-6-one Hydrochloride
• NALOXONE HYDROCHLORIDE

Naloxone hydrochloride, 98%

CAS: 357-08-4

Naloxone hydrochloride, 357-08-4, is a salt form of naloxone, a specific opioid antagonist which competitively binds to opioid receptors in the central nervous system. Learn more.

Formula: C₁₉H₂₂ClNO₄

Purezza: 98%

Colore e forma: White to off-white, Crystals or powder or crystalline powder

Peso molecolare: 363.84

Ref: 02-J60013

Naloxone hydrochloride

CAS: 357-08-4

Naloxone hydrochloride

Formula: C₁₉H₂₁NO₄HCl

Purezza: 90.6%

Colore e forma: White To Off-White

Peso molecolare: 363.12374

Ref: 47-548

Naloxone HCl

CAS: 357-08-4

Formula: C₁₉H₂₁NO₄·HCl

Colore e forma: White To Off-White Solid

Peso molecolare: 327.38 36.46

Ref: 4Z-N-211

Naloxone Hydrochloride

CAS: 357-08-4

Formula: C₁₉H₂₁NO₄HCl

Peso molecolare: 327.4 : 36.46

Ref: ST-EA-CP-N37001

Naloxone Hydrochloride

Prodotto controllato

CAS: 357-08-4

Stability Hygroscopic
Applications Naloxone Hydrochloride is a specific opioid antagonist. Narcotic antagonist.
References Jasinski, D.R., et al.: J. Pharmacol. Exp. Ther., 157, 420 (1967), McNicholas, L.F., et al.: Drugs, 27, 81 (1984), Hasson, M.M.A., et al.: Anal. Profiles Drug Subs., 14, 453 (1985), Stowe, C., et al.: Ann. Pharmacother., 27, 447 (1993)

Formula: C₁₉H₂₁NO₄·ClH

Colore e forma: Neat

Peso molecolare: 363.84

Ref: TR-N285000

Naloxone hydrochloride

Prodotto controllato

CAS: 357-08-4

Naloxone hydrochloride is a competitive antagonist at mu-, delta- and kappa-opioid receptors. Naloxone binding to receptors blocks the effects of opioids such as morphine, heroin, or oxycodone. Naloxone has been shown to be effective in treating acute overdoses of these drugs and reversing the depression of respiratory function that accompanies opioid overdose. It is also used to alleviate withdrawal symptoms and in the treatment of neonatal abstinence syndrome (NAS). NAS is a condition that occurs when infants are exposed to addictive levels of opioids in utero and go through withdrawal after birth.

Formula: C₁₉H₂₁NO₄•HCl

Purezza: (%) Min. 95%

Colore e forma: Powder

Peso molecolare: 363.84 g/mol

Ref: 3D-FN26128