CAS 35943-35-2

Triciribina

Descrizione:

Triciribina, noto anche con il suo nome chimico 2-amino-5-(4-(2-(4-(2-amino-1,2-diidro-3H-pirrolo[3,4-b]chinolina-1-il)etil)fenil)-1H-pirazol-1-il)fenil)-1H-pirrolo-3-carbossilico, è un composto sintetico studiato principalmente per le sue potenziali applicazioni terapeutiche, in particolare in oncologia. È riconosciuto come un inibitore della chinasi proteica, che colpisce specificamente la via Akt, che gioca un ruolo cruciale nella sopravvivenza e proliferazione cellulare. Triciribina è stato studiato per la sua capacità di indurre apoptosi nelle cellule tumorali e migliorare l'efficacia di altri agenti anticancro. Il composto è caratterizzato dalla sua complessa struttura molecolare, che include più anelli aromatici e gruppi funzionali che contribuiscono alla sua attività biologica. In termini di solubilità, Triciribina mostra una solubilità moderata nei solventi organici, ma la sua solubilità in acqua è limitata, il che può influenzare la sua biodisponibilità. Con il proseguire della ricerca, la farmacocinetica, il profilo di sicurezza e il pieno potenziale terapeutico di Triciribina sono oggetto di indagine continua.

Formula: C₁₃H₁₆N₆O₄

InChI: InChI=1/C13H16N6O4/c1-18-11-7-5(10(14)17-18)2-19(12(7)16-4-15-11)13-9(22)8(21)6(3-20)23-13/h2,4,6,8-9,13,20-22H,3H2,1H3,(H2,14,17)

InChI key: InChIKey=HOGVTUZUJGHKPL-HTVVRFAVSA-N

SMILES: NC=1C=2C=3C(N(C2)[C@@H]4O[C@H](CO)[C@@H](O)[C@H]4O)=NC=NC3N(C)N1

Sinonimi:

• 1,4,5,6,8-Pentaazaacenaphthylen-3-amine, 1,5-dihydro-5-methyl-1-β-<span class="text-smallcaps">D</span>-ribofuranosyl-
• 1,4,5,6,8-pentaazaacenaphthylen-3-amine, 1,5-dihydro-5-methyl-1-beta-D-ribofuranosyl-
• 1,5-Dihydro-5-methyl-1-b-D-ribofuranosyl-1,4,5,6,8-pentaazaacennaphthylen-3-amine
• 1,5-Dihydro-5-methyl-1-β-<span class="text-smallcaps">D</span>-ribofuranosyl-1,4,5,6,8-pentaazaacenaphthylen-3-amine
• 35943-35-2
• 5-Methyl-1-Pentofuranosyl-1,5-Dihydro-1,4,5,6,8-Pentaazaacenaphthylen-3-Amine
• 5-Methyl-1-b-D-ribofuranosyl-1,5-dihydro-1,4,5,6,8-pentaazaacenaphthylen-3-amine
• 5-methyl-1-(beta-D-ribofuranosyl)-1,5-dihydro-1,4,5,6,8-pentaazaacenaphthylen-3-amine
• 6-Amino-4-methyl-8-(β-<span class="text-smallcaps">D</span>-ribofuranosyl)-4H,8H-pyrrolo[4,3,2-de]pyrimido[4,5-c]pyridazine
• AKT Inhibitor V
• Api-2
• NSC 154020
• Triciribidine
• 1,5-Dihydro-5-methyl-1-β-D-ribofuranosyl-1,4,5,6,8-pentaazaacenaphthylen-3-amine
• Triciribine
• 1,4,5,6,8-Pentaazaacenaphthylen-3-amine, 1,5-dihydro-5-methyl-1-β-D-ribofuranosyl-
• 6-Amino-4-methyl-8-(β-D-ribofuranosyl)-4H,8H-pyrrolo[4,3,2-de]pyrimido[4,5-c]pyridazine
• Triciribine hydrate
• RNF49
• Anti-Myosin ia
• TRICYCLIC NUCLEOSIDE
• MYO1A
• VD-0002
• Anti-MYO1A antibody produced in rabbit
• TCN
• Anti-Myhl
• 1,4,5,6,8-pentaazaacenaphthylene,3-amino-1,5-dihydro-5-methyl-1-beta-d-ribof
• 1,4,5,6,8-pentaazaacenaphthylen-3-amine,1,5-dihydro-5-methyl-1-beta-d-ribofura
• IAP1
• 4,5,6,8-pentaazaacenaphthylen-5-dihydro-5-methyl-1-beta-d-ribofuranosyl-1
• Brush border myosin I
• 1,5-Dihydro-5-methyl-1-beta-D-ribofuranosyl-1,4,5,6,8-pentaazaacenaphthylen-3-amine Triciribine
• AKT/PKB SIGNALING INHIBITOR-2
• hthylene
• ANTI-CIAP2 (BIRC3)(N-TERMINAL) antibody produced in rabbit
• 3-amine
• pentaazacentopthylene
• API-2 (Tricirbine)
• (2R,3R,4S,5R)-2-(3-aMino-5-Methyl-1,4,5,6,8-pentaazaacenaphthylen-1(5H)-yl)-5-(hydroxyMethyl)tetrahydrofuran-3,4-diol
• Myosin-Ia
• ANTI-MYO1A (CENTER S291) antibody produced in rabbit
• Anti-Dfna48
• DFNA48
• MIHC
• 6-AMINO-4-METHYL-8-(BETA-D-RIBOFURANOSYL)-4H,8H-PYRROLO[4,3,2-DE]PYRIMIDO[4,5-C]PYRIDAZINE
• 1,5-DIHYDRO-5-METHYL-1-BETA-D-RIBOFURANOSYL-1,4,5,6,8-PENTAAZAACENAPHTHYLEN-3-AMINE
• MYHL
• Inhibitor V
• 3-amino-1,5-dihydro-5-methyl-1-beta-d-ribofuranosyl-1,4,5,6,8-pentaazaacenap
• BBMI
• BIRC3
• uranosyl-
• nosyl-

API-2

CAS: 35943-35-2

Formula: C₁₃H₁₆N₆O₄

Purezza: 95%

Colore e forma: Solid

Peso molecolare: 320.3039

Ref: IN-DA00C0BN

Triciribine

CAS: 35943-35-2

Formula: C₁₃H₁₆N₆O₄·xH₂O

Peso molecolare: 320.30 (anhydrous)

Ref: 7W-GN7110

Triciribine

CAS: 35943-35-2

Triciribine

Purezza: ≥98%

Peso molecolare: 320.3g/mol

Ref: 54-BUP04786

(2R,3R,4S,5R)-2-(3-Amino-5-Methyl-1,4,5,6,8-Pentaazaacenaphthylen-1(5H)-Yl)-5-(Hydroxymethyl)Tetrahydrofuran-3,4-Diol

CAS: 35943-35-2

(2R,3R,4S,5R)-2-(3-Amino-5-Methyl-1,4,5,6,8-Pentaazaacenaphthylen-1(5H)-Yl)-5-(Hydroxymethyl)Tetrahydrofuran-3,4-Diol

Purezza: 98%

Peso molecolare: 320.3g/mol

Ref: 54-OR1023082

Tricirbine-13C5

CAS: 35943-35-2

Formula: C₅C₈H₁₆N₆O₄

Peso molecolare: 325.25

Ref: 4Z-T-166003

Triciribine

CAS: 35943-35-2

Triciribine (NSC-154020) is a DNA synthesis inhibitor, and it also inhibits Akt and HIV-1/2.

Formula: C₁₃H₁₆N₆O₄

Purezza: 99.01% - 99.87%

Colore e forma: Solid

Peso molecolare: 320.3

Ref: TM-T6065

Tricirbine

CAS: 35943-35-2

Formula: C₁₃H₁₆N₆O₄

Peso molecolare: 320.31

Ref: 4Z-T-166001

Triciribine

CAS: 35943-35-2

Protein kinase B inhibitor;

Formula: C₁₃H₁₆N₆O₄

Purezza: Min. 95%

Colore e forma: White/Off-White Solid

Peso molecolare: 320.3 g/mol

Ref: 3D-NT08796

Triciribine

Prodotto controllato

CAS: 35943-35-2

Applications Triciribine is an antitumor tricyclic nucleoside. Triciribine acts as a potent, small-molecule inhibitor of AKT phosphorylation in subjects with solid tumors contining activated AKT. Triciribine is also a selective inhibitor of HIV-1 and HIV-2, including strains known to be resistant to AZT or TIBO.
References Garrett, C.R. et al.: Invest. New Drugs, 29, 1381 (2011); Ptak, R.G. et al.: AIDS Res. Human Retrovir., 14, 1315 (1998); Bennett, L.L. et al.: BIochem. Pharmacol., 27, 233 (1978);

Formula: C₁₃H₁₆N₆O₄

Colore e forma: Neat

Peso molecolare: 320.30

Ref: TR-T774245