CAS 367514-87-2

Lurasidone

Descrizione:

Lurasidone è un farmaco antipsicotico atipico utilizzato principalmente nel trattamento della schizofrenia e del disturbo bipolare. Funziona come un antagonista del recettore della dopamina D2 e un antagonista del recettore della serotonina 5-HT2A, il che contribuisce ai suoi effetti terapeutici. La formula chimica di Lurasidone è C24H25ClN2O2S e presenta una struttura di tienobenzodiazepina. Lurasidone è noto per il suo profilo di effetti collaterali relativamente favorevole rispetto ad altri antipsicotici, in particolare in termini di effetti collaterali metabolici. Viene tipicamente somministrato per via orale e ha una biodisponibilità moderata, con la sua farmacocinetica influenzata dall'assunzione di cibo. Il farmaco viene metabolizzato principalmente dall'enzima epatico CYP3A4, che può essere influenzato da altri farmaci che inducono o inibiscono questo enzima. Gli effetti collaterali comuni possono includere sedazione, akatisia e disturbi gastrointestinali. In generale, Lurasidone rappresenta un significativo progresso nella gestione dei disturbi psicotici, offrendo un equilibrio tra efficacia e tollerabilità.

Formula: C₂₈H₃₆N₄O₂S

InChI: InChI=1/C28H36N4O2S/c33-27-24-18-9-10-19(15-18)25(24)28(34)32(27)17-21-6-2-1-5-20(21)16-30-11-13-31(14-12-30)26-22-7-3-4-8-23(22)35-29-26/h3-4,7-8,18-21,24-25H,1-2,5-6,9-17H2/t18-,19+,20-,21-,24+,25-/m0/s1

InChI key: InChIKey=PQXKDMSYBGKCJA-CVTJIBDQSA-N

SMILES: O=C1[C@]2([C@]([C@]3(C[C@@]2(CC3)[H])[H])(C(=O)N1C[C@H]4[C@H](CN5CCN(CC5)C=6C=7C(SN6)=CC=CC7)CCCC4)[H])[H]

Sinonimi:

• (3aR,4S,7R,7aS)-2-((1R,2R)-2-(4-(1,2-Benzothiazol-3-yl)piperazin-1-ylmethyl)cyclohexylmethyl)hexahydro-4,7-methano-2H-isoindole-1,3-dione
• (3aR,4S,7R,7aS)-2-[[(1R,2R)-2-[[4-(1,2-Benzisothiazol-3-yl)-1-piperazinyl]methyl]cyclohexyl]methyl]hexahydro-4,7-methano-1H-isoindole-1,3(2H)-dione
• (3aR,4S,7R,7aS)-2-{[(1R,2R)-2-{[4-(1,2-benzothiazol-3-yl)piperazin-1-yl]methyl}cyclohexyl]methyl}hexahydro-1H-4,7-methanoisoindole-1,3(2H)-dione
• 2-[[(1R,2R)-2-[[4-(1,2-Benzoisothiazol-3-yl)-1-piperazinyl]methyl]cyclohexyl]methyl]hexahydro-(3aS,4R,7S,7aR)-4,7-methano-1H-isoindole-1,3(2H)-dione
• 4,7-Methano-1H-isoindole-1,3(2H)-dione, 2-[[(1R,2R)-2-[[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]methyl]cyclohexyl]methyl]hexahydro-, (3aR,4S,7R,7aS)-
• Lurasidone
• 4-{[(1R,2R)-2-{[4-(2$l^{4}-thia-6-azatricyclo[5.4.0.0^{2,6}]undeca-1(11),2,4,7,9-pentaen-5-yl)piperazin-1-yl]Methyl}cyclohexyl]Methyl}-4-azatricyclo[5.2.1.0^{2,6}]deca-1(9),2(6),7-triene-3,5-dione
• Lurasidone Base
• Lurasidone, >=98%
• Lurasidone (SM13496)
• urasidone

Lurasidone

CAS: 367514-87-2

Formula: C₂₈H₃₆N₄O₂S

Purezza: >98.0%(HPLC)(N)

Colore e forma: White to Orange to Green powder to crystaline

Peso molecolare: 492.68

Ref: 3B-L0280

(3aR,4S,7R,7aS)-2-((1R,2R)-2-(4-(1,2-Benzothiazol-3-yl)piperazin-1-ylmethyl)cyclohexylmethyl)hexahydro-4,7-methano-2H-isoindole-1,3-dione

CAS: 367514-87-2

Formula: C₂₈H₃₆N₄O₂S

Purezza: 99%

Colore e forma: Solid

Peso molecolare: 492.6760

Ref: IN-DA0037AT

Lurasidone

CAS: 367514-87-2

Lurasidone

Purezza: 99%

Peso molecolare: 492.68g/mol

Ref: 54-OR1028250

Lurasidone

CAS: 367514-87-2

Lurasidone

Purezza: ≥98%

Peso molecolare: 492.68g/mol

Ref: 54-BUP06576

Lurasidone

CAS: 367514-87-2

Lurasidone (SM-13496) is an antagonist of both dopamine D2 and 5-HT7(IC50=1.68 and 0.495 nM, respectively).It also a partial agonist of 5-HT1A receptor(IC50 : 6

Formula: C₂₈H₃₆N₄O₂S

Purezza: 99.78% - 99.91%

Colore e forma: Solid

Peso molecolare: 492.68

Ref: TM-T21337

Lurasidone

Prodotto controllato

CAS: 367514-87-2

Applications Lurasidone (cas# 367514-87-2) is a useful research chemical.

Formula: C₂₈H₃₆N₄O₂S

Colore e forma: Neat

Peso molecolare: 492.68

Ref: TR-L474958

Lurasidone

Prodotto controllato

CAS: 367514-87-2

Lurasidone is an atypical antipsychotic medication, which is a synthetic compound developed through pharmaceutical chemical synthesis. It functions primarily as a dopamine D2 and serotonin 5-HT2A receptor antagonist, while also exhibiting partial agonism at certain serotonin receptors and antagonism at other neurotransmitter sites such as alpha-2 adrenergic receptors.Lurasidone is widely utilized in the medical field for the treatment of psychiatric disorders, notably schizophrenia and bipolar depression. Its multifaceted receptor activity profile helps in modulating neurotransmission imbalances associated with these conditions. By targeting specific neural pathways, lurasidone can effectively alleviate symptoms of psychosis, improve mood stability, and enhance overall cognitive function in patients. Researchers and clinicians value lurasidone for its efficacy in symptom management alongside a favorable side effect profile compared to older antipsychotics. Its pharmacological properties make it an important tool in advancing therapeutic approaches for complex psychiatric disorders.

Formula: C₂₈H₃₆N₄O₂S

Purezza: Min. 95%

Peso molecolare: 492.68 g/mol

Ref: 3D-SPA51487