CAS 37558-16-0

forbolo 12,13-dibutirrato

Descrizione:

forbolo 12,13-dibutirrato (PDBu) è un estere di fobolo sintetico derivato dal composto naturale fobolo, che si ottiene dalla resina della pianta Euphorbia. È caratterizzato dalla sua capacità di agire come un potente promotore tumorale e un attivatore della proteina chinasi C (PKC), rendendolo uno strumento prezioso nella ricerca sul cancro e negli studi di segnalazione cellulare. PDBu è un composto lipofilo, che gli consente di penetrare facilmente nelle membrane cellulari e interagire con i bersagli cellulari. La sua struttura include due gruppi butirrato esterificati allo scheletro di fobolo, aumentando la sua attività biologica rispetto ad altri esteri di fobolo. PDBu è spesso utilizzato in ambienti di laboratorio per indurre differenziazione in vari tipi di cellule e per studiare i meccanismi di trasduzione del segnale. Inoltre, è stato dimostrato che influenza vari processi cellulari, tra cui proliferazione, apoptosi ed espressione genica. A causa dei suoi potenti effetti biologici, PDBu è maneggiato con cura negli ambienti di ricerca e il suo utilizzo è soggetto a linee guida normative.

Formula: C₂₈H₄₀O₈

InChI: InChI=1/C28H40O8/c1-7-9-20(30)35-24-16(4)27(34)18(22-25(5,6)28(22,24)36-21(31)10-8-2)12-17(14-29)13-26(33)19(27)11-15(3)23(26)32/h11-12,16,18-19,22,24,29,33-34H,7-10,13-14H2,1-6H3

InChI key: InChIKey=BQJRUJTZSGYBEZ-YVQNUNKESA-N

SMILES: O(C(CCC)=O)[C@@]12[C@@](C1(C)C)([C@]3([C@](O)([C@H](C)[C@H]2OC(CCC)=O)[C@]4([C@](O)(CC(CO)=C3)C(=O)C(C)=C4)[H])[H])[H]

Sinonimi:

• (1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1,1a,1b,4,4a,5,7a,7b,8,9-decahydro-9aH-cyclopropa[3,4]benzo[1,2-e]azulene-9,9a-diyl dibutanoate
• 12,13-Di-O-butyrylphorbol
• 4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1,1a,1b,4,4a,5,7a,7b,8,9-decahydro-9aH-cyclopropa[3,4]benzo[1,2-e]azulene-9,9a-diyl dibutanoate
• 4β-Phorbol 12,13-dibutyrate
• 9aH-Cyclopropa[3,4]benz[1,2-e]azulene, butanoic acid deriv.
• Butanoic acid, (1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-1,1a,1b,4,4a,5,7a,7b,8,9-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-9aH-cyclopropa(3,4)benz(1,2-e)azulene-9,9a-diyl ester
• Butanoic acid, 1,1a,1b,4,4a,5,7a,7b,8,9-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-9aH-cyclopropa[3,4]benz[1,2-e]azulene-9,9a-diyl ester, [1aR-(1aα,1bβ,4aβ,7aα,7bα,8α,9β,9aα)]-
• Butanoic acid, 1,1a,1b,4,4a,5,7a,7b,8,9-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-9ah-cyclopropa(3,4)benz(1,2-e)azulene-9,9a-diyl ester, (1aR-(1a-alpha,1b-beta,4a-beta,7a-alpha,7b-alpha,8-alpha,9-beta,9a-alpha))-
• Nsc 622507
• Phorbol dibutyrate
• Phorbol 12,13-dibutyrate
• Phorbol-12,13-dibutyrate
• C03634
• (1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-1a,1b,4,4a,5,7a,7b,8,9,9a-Decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1H-cyclopropa[3,4]benz[1,2-e]azulen-9,9a-diylbutanoicacidester
• (1aR)-1,1aα,1bβ,4,4a,7aα,7b,8,9,9a-Decahydro-5-oxo-3-(hydroxymethyl)-1,1,6,8α-tetramethyl-5H-cyclopropa[3,4]benz[1,2-e]azulene-4aα,7bα,9β,9aα-tetrol 9,9a-dibutyrate
• Phorbol 12,13-Dibutyrate >99%
• Phorbol-12,13-dibutyrate - CAS 37558-16-0 - Calbiochem
• (1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-4a,7b-dihydroxy-3-(hydroxyMethyl)-1,1,6,8-tetraMethyl-5-oxo-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-1H-cyclopropa[3,4]benzo[1,2-e]azulene-9,9a-diyl dibutyrate
• PHORBOL 12,13-DIBUTYRATE, 4BETA
• Phorbol 12,13-dibutanoate
• hyl)-1,1,6,8-tetramethyl-5-oxo-9ah-cyclopropa(3,4)benz(1,2-e)azulene-9,9a-diy
• butanoicacid,1,1a,1b,4,4a,5,7a,7b,8,9-decahydro-4a,7b-dihydroxy-3-(hydroxymet
• lester,(1ar-(1a-alpha,1b-beta,4a-beta,7a-alpha,7b-alpha,8-alpha,9-beta,9a-al
• (1aR)-1,1aα,1bβ,4,4a,7aα,7b,8,9,9a-Decahydro-4aβ,7bα-dihydroxy-3-hydroxymethyl-1,1,6,8α-tetramethyl-5-oxo-5H-cyclopropa[3,4]benz[1,2-e]azulene-9β,9aα-diol 9,9a-dibutyrate
• 9β,9aα-Bis(butyryloxy)-1,1aα,1bβ,4,4a,7aα,7b,8,9,9a-decahydro-4aβ,7bα-dihydroxy-3-(hydroxymethyl)-1,1,6,8α-tetramethyl-5H-cyclopropa[3,4]benz[1,2-e]azulen-5-one

Phorbol 12,13-Dibutyrate

CAS: 37558-16-0

Formula: C₂₈H₄₀O₈

Purezza: 98%

Peso molecolare: 504.6124

Ref: IN-DA00BXZ4

Phorbol 12,13-dibutyrate

CAS: 37558-16-0

Formula: C₂₈H₄₀O₈

Purezza: ≥ 98.0%

Colore e forma: White to pale yellow or yellow solid

Peso molecolare: 504.61

Ref: 7W-GL3377

Phorbol 12,13-Dibutyrate

CAS: 37558-16-0

Phorbol 12,13-Dibutyrate

Formula: C₂₈H₄₀O₈

Purezza: >99%

Colore e forma: solid

Peso molecolare: 504.61239g/mol

Ref: 54-BIP1016

Phorbol 12,13-dibutyrate

CAS: 37558-16-0

Phorbol 12,13-dibutyrate (Phorbol dibutyrate) is a PKC activator that induces contraction of isolated rabbit vascular smooth muscle.

Formula: C₂₈H₄₀O₈

Purezza: 99.32% - 99.37%

Colore e forma: Solid

Peso molecolare: 504.61

Ref: TM-T16526

Phorbol 12,13-dibutyrate

CAS: 37558-16-0

Phorbol 12,13-dibutyrate is a potent inducer of protein kinase C (PKC) and is used as a tool to study PKC activity. It has been shown to induce the phosphorylation of certain proteins in human cells. This compound also induces the release of inflammatory mediators from polymorphonuclear leucocytes, which are white blood cells. Phorbol 12,13-dibutyrate is also used as a model system for studying the human papillary muscle and its biochemical properties. The effects of phorbol 12,13-dibutyrate on hl-60 cells have been studied extensively. This compound inhibits protein synthesis by preventing the binding of aminoacyl-tRNA to the ribosome and by inhibiting translocation of mRNA into the cytoplasm.

Formula: C₂₈H₄₀O₈

Purezza: Min. 95 Area-%

Colore e forma: Powder

Peso molecolare: 504.61 g/mol

Ref: 3D-MBA55816