CAS 37784-17-1

N-Boc-D-prolina

Descrizione:

N-Boc-D-prolina, con il numero CAS 37784-17-1, è un derivato dell'aminoacido prolina, caratterizzato dalla presenza di un gruppo protettivo tert-butyloxycarbonyl (Boc) sull'atomo di azoto. Questa modifica ne migliora la stabilità e la solubilità, rendendolo un intermedio prezioso nella sintesi di peptidi e nella chimica organica. N-Boc-D-prolina è tipicamente un solido cristallino bianco a bianco sporco, ed è solubile in comuni solventi organici come il diclorometano e il dimetilformamide, ma meno solubile in acqua. Il gruppo Boc funge da moiety protettivo che può essere rimosso in condizioni acide, consentendo la deprotezione selettiva del gruppo amminico quando necessario. Questo composto è spesso utilizzato nella sintesi di peptidi e altre molecole bioattive, grazie alla sua capacità di facilitare la formazione di legami peptidici mantenendo la chiralità del residuo D-prolina. Le sue caratteristiche strutturali e reattività lo rendono un importante mattone nella chimica medicinale e nello sviluppo di farmaci.

Formula: C₁₀H₁₆NO₄

InChI: InChI=1/C10H17NO4/c1-10(2,3)15-9(14)11-6-4-5-7(11)8(12)13/h7H,4-6H2,1-3H3,(H,12,13)/p-1/t7-/m1/s1

SMILES: CC(C)(C)OC(=O)N1CCC[C@@H]1C(=O)[O-]

Sinonimi:

• (2R)-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylate
• 1-Boc-D-proline
• Boc-D-Pro-OH
• Boc-D-proline

N-(tert-Butoxycarbonyl)-D-proline

CAS: 37784-17-1

Formula: C₁₀H₁₇NO₄

Purezza: >98.0%(T)(HPLC)

Colore e forma: White to Almost white powder to crystal

Peso molecolare: 215.25

Ref: 3B-B2977

N-Boc-D-proline, 98+%

CAS: 37784-17-1

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Sci

Formula: C₁₀H₁₇NO₄

Purezza: 98+%

Colore e forma: White, Crystals or powder or crystalline powder

Peso molecolare: 215.25

Ref: 02-L08826

Boc-D-Pro-OH

CAS: 37784-17-1

Bachem ID: 4000664.

Formula: C₁₀H₁₇NO₄

Purezza: > 99.5%

Colore e forma: White

Peso molecolare: 215.25

Ref: 01-4000664

N-Boc-D-proline

CAS: 37784-17-1

Formula: C₁₀H₁₇NO₄

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 215.2463

Ref: IN-DA0035CW

N-Boc-D-proline

CAS: 37784-17-1

N-Boc-D-proline

Purezza: 98%

Colore e forma: White Powder

Peso molecolare: 215.25g/mol

Ref: 54-OR307074

N-Boc-D-proline

CAS: 37784-17-1

Formula: C₁₀H₁₇NO₄

Purezza: ≥ 98.0%

Colore e forma: White powder or crystals

Peso molecolare: 215.25

Ref: 7W-GM9500

Boc-D-Pro-OH

CAS: 37784-17-1

M03316 - Boc-D-Pro-OH

Formula: C₁₀H₁₇NO₄

Purezza: 97%

Colore e forma: Solid, Crystalline Powder or Powder

Peso molecolare: 215.249

Ref: 10-M03316

N-Boc-D-proline

CAS: 37784-17-1

Formula: C₁₀H₁₇NO₄

Peso molecolare: 215.25

Ref: 4Z-P-166060

tert-Butoxycarbonyl-D-proline

Prodotto controllato

CAS: 37784-17-1

Applications tert-Butoxycarbonyl-D-proline is Boc protected D-proline (P755990). It is used to prepare trichostatin A and trapoxin B analogs as histone deacetylase inhibitors. It is also used to prepare potent and selective nonpeptide inhibitors of caspases 3 and 7.
References Jung, M., et al.: Bioorg. Med. Chem. Lett., 7, 1655 (1997); Lee, D., et al.: J. Med. Chem,, 44, 2015 (2001)

Formula: C₁₀H₁₇NO₄

Colore e forma: Neat

Peso molecolare: 215.25

Ref: TR-B692535

N-Boc-D-proline

CAS: 37784-17-1

N-Boc-D-proline is a lipase inhibitor that is used in the preparation of quinine, aldehyde, and carboxylate. N-Boc-D-proline has been shown to inhibit the activity of the sodium channels, which may be due to its ability to bind to the termini of these channels. The inhibition of sodium channels can lead to a decrease in nerve excitability and seizures. N-Boc-D-proline was synthesized by an organocatalytic method using sodium bicarbonate as the catalyst. It was found that this compound was stereoselective with respect to its activity on different enantiomers of chiral substrates. Preparative methods for N-Boc-D-proline include column chromatography or crystallization with diethyl ether or ethyl acetate. The isolated yield is about 99%.

Formula: C₁₀H₁₇NO₄

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 215.25 g/mol

Ref: 3D-FB11371

Boc-D-Pro-OH

CAS: 37784-17-1

Boc-D-Pro-OH is a model compound for the synthesis of peptides. Boc-D-Pro-OH has been used in many surface-enhanced Raman spectroscopy studies to investigate the stereochemistry of glycosidic bonds. It has also been used in pharmacokinetic studies to investigate the drug's absorption, distribution, metabolism, and excretion (ADME) properties. The solute is soluble in water due to its hydrophilic nature. Boc-D-Pro-OH is an enantiomer of Boc-L-Pro-OH and a functional group that contains a trifluoromethyl group. This chemical can be used in Tools for Peptide Synthesis with other compounds to form peptides with specific amino acid sequences.

Formula: C₁₀H₁₇NO₄

Purezza: Min. 95%

Peso molecolare: 215.25 g/mol

Ref: 3D-BDP-2610

BOC-D-Proline extrapure, 99%

CAS: 37784-17-1

Formula: C₁₀H₁₇NO₄

Purezza: min. 99%

Colore e forma: White, Crystalline compound

Peso molecolare: 215.30

Ref: SR-93481