CAS 38048-32-7

S-(4-Nitrobenzil)-6-tioinosina

Descrizione:

S-(4-Nitrobenzil)-6-tioinosina è un composto chimico che appartiene alla classe degli analoghi dei nucleosidi, specificamente purine modificate. Presenta una struttura di tioinosina, in cui l'atomo di zolfo sostituisce l'ossigeno nello zucchero ribosio, migliorando la sua attività biologica. La presenza del gruppo 4-nitrobenzile contribuisce alle sue proprietà uniche, influenzando potenzialmente la sua interazione con obiettivi biologici. Questo composto è spesso studiato per il suo ruolo nella ricerca biochimica, in particolare nel contesto del metabolismo dei nucleosidi e delle sue potenziali applicazioni terapeutiche. Può mostrare varie attività biologiche, comprese proprietà antivirali o antitumorali, a causa delle sue modifiche strutturali. Il numero CAS 38048-32-7 identifica in modo univoco questa sostanza nei database chimici, facilitando il suo studio e la sua applicazione nella ricerca scientifica. Come molti analoghi dei nucleosidi, la sua solubilità, stabilità e reattività possono variare, rendendo essenziale considerare questi fattori nei progetti sperimentali. In generale, S-(4-Nitrobenzil)-6-tioinosina rappresenta un composto significativo nel campo della chimica medicinale e della biochimica.

Formula: C₁₇H₁₇N₅O₆S

InChI: InChI=1/C17H17N5O6S/c23-5-11-13(24)14(25)17(28-11)21-8-20-12-15(21)18-7-19-16(12)29-6-9-1-3-10(4-2-9)22(26)27/h1-4,7-8,11,13-14,17,23-25H,5-6H2/t11-,13-,14-,17-/m1/s1

InChI key: InChIKey=DYCJFJRCWPVDHY-LSCFUAHRSA-N

SMILES: O[C@H]1[C@H](N2C=3C(N=C2)=C(SCC4=CC=C(N(=O)=O)C=C4)N=CN3)O[C@H](CO)[C@H]1O

Sinonimi:

• 6-[(4-Nitrobenzyl)thio]-9-β-D-ribofuranosylpurine
• 6-S-[(4-Nitrophenyl)methyl]-6-thioinosine
• S-(p-Nitrobenzyl)-6-mercapto-9-β-D-ribofuranosylpurine
• Inosine, 6-S-[(4-nitrophenyl)methyl]-6-thio-
• S-(4-Nitrobenzyl)-6-thioinosine
• NSC 296962
• S-(4-Nitrobenzyl)-6-thioinosine (NBTI, NBMPR)
• 6-(p-nitrobenzylthio)inosine
• 6-[(4-NITROBENZYL)THIO]-9-BETA-D-RIBOFURANOSYLPURINE
• 6-(((4-nitrophenyl)methyl)thio)-9-beta-d-ribofuranosyl-9h-purin
• 6-[(4-Nitrobenzyl)-mercapto]-inosine
• S-(p-Nitrobenzyl)-6-mercapto-9--D-ribofuranosylpurine
• 6-(((4-nitrophenyl)methyl)thio)-9-beta-d-ribofuranosyl-9h-purine
• 6-[(4-Nitrobenzyl)thio]-9-β-D-ribofuranosyl-9H-purine
• S-(4-Nitrobenzyl)-6-thioinosine,99%
• 6-[[(4-Nitrophenyl)methyl]thio]-9-(β-D-ribofuranosyl)-9H-purine
• NBMPR, NBTI, 6-[(4-Nitrobenzyl)thio]-9-β-D-ribofuranosylpurine
• nitrobenzylthioinosine
• S-(P-NITROBENZYL)-6-THIOINOSINE
• S-(4-NITROBENZYL)-6-THIOINOSINE (NBTI) P OTENT ADENOSINE UPTA
• NBTI
• 4-Nitrobenzyl-6-mercaptoinosine
• (2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(6-((4-nitrobenzyl)thio)-9H-purin-9-yl)tetrahydrofuran-3,4-diol
• S-(P-NITROBENZYL)-6-THIOINOSINE 98+%
• NBMPR

(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(6-((4-nitrobenzyl)thio)-9H-purin-9-yl)tetrahydrofuran-3,4-diol

CAS: 38048-32-7

Formula: C₁₇H₁₇N₅O₆S

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 419.4118

Ref: IN-DA003U66

Nitrobenzylthioinosine

CAS: 38048-32-7

Nitrobenzylthioinosine

Purezza: ≥98%

Peso molecolare: 419.41g/mol

Ref: 54-BUP11914

6-[(4-Nitrobenzyl)Thio]-9-β-D-Ribofuranosylpurine

CAS: 38048-32-7

6-[(4-Nitrobenzyl)Thio]-9-β-D-Ribofuranosylpurine

Purezza: 98%

Peso molecolare: 419.41g/mol

Ref: 54-OR1023078

S-(4-Nitrobenzyl)-6-thioinosine

CAS: 38048-32-7

Formula: C₁₇H₁₇N₅O₆S

Peso molecolare: 419.41

Ref: 7W-GN6805

Nitrobenzylthioinosine

CAS: 38048-32-7

Nitrobenzylthioinosine (NBMPR) is an inhibitor of ENT1 transporter that binds to ENT1 transporter with high affinity.

Formula: C₁₇H₁₇N₅O₆S

Purezza: 99.69% - 99.74%

Colore e forma: Off-White Solid

Peso molecolare: 419.41

Ref: TM-T8551

6-[(4-Nitrobenzyl)thio]-9-β-D-ribofuranosylpurine

CAS: 38048-32-7

Purezza: 98.0%

Peso molecolare: 419.4100036621094

Ref: 10-F547423

S-(4-Nitrobenzyl)-6-thioinosine

CAS: 38048-32-7

S-(4-Nitrobenzyl)-6-thioinosine (SBT) is a nucleoside with biochemical properties that are similar to those of adenosine. SBT is an equilibrative nucleoside, which means that it can bind to both DNA and RNA. It has been shown to be effective in inhibiting the growth of cancer cells in vitro by binding to DNA. SBT binds to the purine nucleotide transporter and prevents the uptake of uridine, adenosine, and other nucleosides into the cell. This process leads to a decrease in intracellular concentrations of these nucleosides. SBT also binds to divalent metal ions such as copper or zinc, which may affect its activity on cancer cells.

Formula: C₁₇H₁₇N₅O₆S

Purezza: Min. 98 Area-%

Colore e forma: White Off-White Powder

Peso molecolare: 419.41 g/mol

Ref: 3D-NN09410

S-(4-Nitrobenzyl)-6-thioinosine

Prodotto controllato

CAS: 38048-32-7

Applications S-(4-Nitrobenzyl)-6-thioinosine is a nucleoside analog and an inhibitor of the human equilibrative nucleoside transporter (hENT1) (1,2,3). Nucleoside transporter inhibitors are useful compounds to investigate anticancer, antiviral, cardioprotective, and neuroprotective agents.
References (1) Zhu, Z., et al.: J. Med. Chem., 46, 831 (2003) (2) Baldwin, S., et al.: J. Biol. Chem., 280, 15880 (2005) (3) Barnes, K., et al.: Circ. Res., 99, 510 (2006)

Formula: C₁₇H₁₇N₅O₆S

Colore e forma: Neat

Peso molecolare: 419.41

Ref: TR-N493695