CAS 38176-02-2

(+)-[3-ciano-3-(3,4-dimetossifenile)es-6-il](5,6-dimetossifenetile)metilammonio cloruro

Descrizione:

La sostanza chimica nota come "(+)-[3-ciano-3-(3,4-dimetossifenile)es-6-il](5,6-dimetossifenetile)metilammonio cloruro" con il numero CAS 38176-02-2 è un composto di ammonio quaternario caratterizzato dalla sua struttura complessa, che include un gruppo ciano, molteplici sostituenti metossilici e una catena esilica. Questo composto presenta proprietà tipiche dei sali di ammonio quaternario, come la solubilità in solventi polari e una potenziale attività biologica. La presenza di gruppi metossilici suggerisce che potrebbe avere una lipofilia migliorata, che può influenzare la sua interazione con le membrane biologiche. Inoltre, il gruppo ciano può conferire caratteristiche uniche di reattività e stabilità. In quanto sale di cloruro, è probabile che sia di natura ionica, contribuendo alla sua solubilità in ambienti acquosi. La stereochimica specifica indicata dalla designazione "(+)" suggerisce che potrebbe presentare proprietà chirali, che possono influenzare il suo profilo farmacologico e le interazioni nei sistemi biologici. In generale, le caratteristiche strutturali uniche di questo composto potrebbero renderlo di interesse nella chimica medicinale e nella farmacologia.

Formula: C₂₇H₃₈N₂O₄·ClH

InChI: InChI=1S/C27H38N2O4.ClH/c1-20(2)27(19-28,22-10-12-24(31-5)26(18-22)33-7)14-8-15-29(3)16-13-21-9-11-23(30-4)25(17-21)32-6;/h9-12,17-18,20H,8,13-16H2,1-7H3;1H/t27-;/m1./s1

InChI key: InChIKey=DOQPXTMNIUCOSY-HZPIKELBSA-N

SMILES: [C@](CCCN(CCC1=CC(OC)=C(OC)C=C1)C)(C(C)C)(C#N)C2=CC(OC)=C(OC)C=C2.Cl

Sinonimi:

• (+)-Verapamil hydrochloride
• (2R)-2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile hydrochloride (1:1)
• (R)-Verapamil hydrochloride
• Benzeneacetonitrile, α-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-α-(1-methylethyl)-, hydrochloride (1:1), (αR)-
• Benzeneacetonitrile, α-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-α-(1-methylethyl)-, monohydrochloride, (R)-
• Benzeneacetonitrile, α-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-α-(1-methylethyl)-, monohydrochloride, (αR)-
• Dexverapamil monohydrochloride
• Lu 33925
• NSC 632821
• (+)-(3-Cyano-3-(3,4-dimethoxyphenyl)hex-6-yl)(5,6-dimethoxyphenethyl)methylammonium chloride
• R(+)-Verapamil hydrate monohydrochloride
• Benzeneacetonitrile, a-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-a-(1-methylethyl)-, monohydrochloride, (aR)- (9CI)
• R(+)-Verapamil monohydrochloride
• (+)-[3-cyano-3-(3,4-diMethoxyphenyl)hex-6-yl](5,6-
• (αR)-α-[3-[[2-(3,4-DiMethoxyphenyl)ethyl]MethylaMino]propyl]-3,4-diMethoxy-α-(1-Methylethyl)-benzeneacetonitrile Hydrochloride
• R(+)-VERAPAMIL MONOHYDROCHLORIDE MONOHYDRATE
• Benzeneacetonitrile, alpha-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-alpha-(1-methylethyl)-, monohydrochloride, (alphaR)-
• R(+)-Verapamil monohydrochloride hydrate

(R)-Verapamil (hydrochloride)

CAS: 38176-02-2

(R)-Verapamil (hydrochloride)

Purezza: 98%

Peso molecolare: 491.06g/mol

Ref: 54-OR1034236

R-Verapamil HCl

CAS: 38176-02-2

Formula: C₂₇H₃₈N₂O₄·HCl

Colore e forma: White To Off-White Solid

Peso molecolare: 454.61 36.46

Ref: 4Z-V-046

R-(+)-Verapamil monohydrochloride hydrate

CAS: 38176-02-2

Formula: C₂₇H₄₁ClN₂O₅

Peso molecolare: 509.08

Ref: 7W-GP6309

(R)-(+)-Verapamil Hydrochloride

Prodotto controllato

CAS: 38176-02-2

Applications (R)-(+)-Verapamil Hydrochloride and both of its isomers inhibit the p-glycoprotein efflux pump in multidrug resistant tumor cells.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Peroutka, S., et al.: J. Ann. Neurol, 23, 500 (1988); Eliason, J.F., et al.: Int. J. Cancer, 46, 113 (1990);

Formula: C₂₇H₃₈N₂O₄·ClH

Colore e forma: Neat

Peso molecolare: 491.06

Ref: TR-V124990

(2R)-2-(3,4-Dimethoxyphenyl)-5-[2-(3,4-dimethoxyphenyl)ethyl-methylamino]-2-isopropylpentanenitrile hydrochloride

CAS: 38176-02-2

(2R)-2-(3,4-Dimethoxyphenyl)-5-[2-(3,4-dimethoxyphenyl)ethyl-methylamino]-2-isopropylpentanenitrile hydrochloride (ZD4054) is a drug that has been shown to be sensitive to the efflux pump in Escherichia coli. It is also able to inhibit multidrug resistance in nematodes and cross-resistance in humans. ZD4054 inhibits multidrug resistance by inhibiting the efflux of drugs from cells. This prevents the development of resistance to antibiotics and other drugs. The mechanism of action for this drug is unknown, but it may affect chloride channels that are found on the cell membrane. ZD4054 has also been shown to be effective against C.elegans and Drosophila melanogaster, two species commonly used for research purposes.

Formula: C₂₇H₃₉ClN₂O₄

Purezza: Min. 95%

Peso molecolare: 491.06 g/mol

Ref: 3D-ID28684

(R)-Verapamil hydrochloride

CAS: 38176-02-2

(R)-Verapamil hydrochloride ((R)-(+)-Verapamil hydrochloride) is an inhibitor of P-Glycoprotein.

Formula: C₂₇H₃₉ClN₂O₄

Colore e forma: Solid

Peso molecolare: 491.06

Ref: TM-T12646