CAS 3862-25-7

7α-Idrossi-4-colesten-3-one

Descrizione:

7α-Idrossi-4-colesten-3-one, con il numero CAS 3862-25-7, è un composto steroideo che gioca un ruolo significativo nel metabolismo del colesterolo ed è un intermedio chiave nella biosintesi degli acidi biliari. Questo composto presenta un gruppo idrossile nella posizione 7α della struttura del colestene, che contribuisce alla sua attività biologica. Si trova tipicamente in vari sistemi biologici, inclusi i tessuti umani, dove è coinvolto nella regolazione dei livelli di colesterolo e può influenzare il metabolismo dei lipidi. La presenza del gruppo idrossile ne migliora la solubilità nei fluidi biologici, facilitando la sua interazione con enzimi e recettori. Inoltre, 7α-Idrossi-4-colesten-3-one è noto per essere un ligando per i recettori X epatici (LXR), che sono recettori nucleari che regolano i geni coinvolti nell'omeostasi lipidica. Le sue caratteristiche strutturali, inclusi il telaio steroideo e i gruppi funzionali, sono cruciali per le sue funzioni biologiche e le potenziali applicazioni terapeutiche nella gestione dei disturbi correlati al colesterolo.

Formula: C₂₇H₄₄O₂

InChI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1

InChI key: InChIKey=IOIZWEJGGCZDOL-RQDYSCIWSA-N

SMILES: C[C@@]12[C@]([C@]3([C@@]([C@]4(C)C(C[C@H]3O)=CC(=O)CC4)(CC1)[H])[H])(CC[C@@]2([C@@H](CCCC(C)C)C)[H])[H]

Sinonimi:

• (7Alpha,8Xi)-7-Hydroxycholest-4-En-3-One
• (7α)-7-Hydroxycholest-4-en-3-one
• 7α-Hydroxy-4-cholesten-3-one
• 7α-Hydroxycholest-4-en-3-one
• Cholest-4-En-3-One, 7-Hydroxy-, (7Alpha,8Xi)-
• Cholest-4-en-3-one, 7-hydroxy-, (7alpha)-
• Cholest-4-en-3-one, 7-hydroxy-, (7α)-
• Cholest-4-en-3-one, 7α-hydroxy-

(7R,8S,9S,10R,13R,14S,17R)-7-hydroxy-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one

CAS: 3862-25-7

Formula: C₂₇H₄₄O₂

Purezza: %

Colore e forma: Solid

Peso molecolare: 400.6371

Ref: IN-DA00C9GN

Cholesterol Impurity 36

CAS: 3862-25-7

Formula: C₂₇H₄₄O₂

Peso molecolare: 400.65

Ref: 4Z-C-5345

7α-Hydroxy-4-cholesten-3-one

CAS: 3862-25-7

7α-Hydroxy-4-cholesten-3-one

Purezza: ≥98%

Peso molecolare: 400.64g/mol

Ref: 54-BUP00441

Cholesterol Impurity 36-d7

CAS: 3862-25-7

Formula: C₂₇H₃₇D₇O₂

Peso molecolare: 407.69

Ref: 4Z-C-5346

7Alpha-Hydroxy-4-cholesten-3-one-d7 (contains 2% d0)

Prodotto controllato

CAS: 3862-25-7

Applications Labelled 7α-Hydroxy-4-cholesten-3-one (H825130). 7α-Hydroxy-4-cholesten-3-one is a metabolite of Cholesterol (C432501).
References Connor, W., et al.: J, Clin. Invest., 48, 1363 (1969), Nestel, P., et al.: Metabolism, 24, 189 (1975), Ellegard, L., et al.: Eur. J. Clin. Nutr., 45, 451 (1991), Pedersen, A., et al.: J. Lipid Res., 41, 1901 (2000),

Formula: C₂₇H₃₇D₇O₂

Colore e forma: Neat

Peso molecolare: 407.68

Ref: TR-H825133

7alpha-Hydroxy-4-cholesten-3-one-d7

Prodotto controllato

CAS: 3862-25-7

Applications Labelled 7α-Hydroxy-4-cholesten-3-one (H825130). 7α-Hydroxy-4-cholesten-3-one is a metabolite of Cholesterol (C432501).
References Connor, W., et al.: J, Clin. Invest., 48, 1363 (1969),

Formula: C₂₇H₃₇D₇O₂

Colore e forma: White To Off-White

Peso molecolare: 407.68

Ref: TR-H825132

7alpha-Hydroxy-4-cholesten-3-one

CAS: 3862-25-7

Applications 7α-Hydroxy-4-cholesten-3-one is a metabolite of Cholesterol (C432501).
References Connor, W., et al.: J, Clin. Invest., 48, 1363 (1969), Nestel, P., et al.: Metabolism, 24, 189 (1975), Ellegard, L., et al.: Eur. J. Clin. Nutr., 45, 451 (1991), Pedersen, A., et al.: J. Lipid Res., 41, 1901 (2000),

Formula: C₂₇H₄₄O₂

Colore e forma: Neat

Peso molecolare: 400.64

Ref: TR-H825130

7α-Hydroxy-4-cholesten-3-one

Prodotto controllato

CAS: 3862-25-7

Intermediate in bile acids biosynthesis

Formula: C₂₇H₄₄O₂

Purezza: Min. 98 Area-%

Colore e forma: Powder

Peso molecolare: 400.64 g/mol

Ref: 3D-FH24257

7-Hydroxy-4-cholesten-3-one-D7

Prodotto controllato

CAS: 3862-25-7

7-Hydroxy-4-cholesten-3-one-D7 (7OHCD7) is a metabolite of the bile acid, cholic acid. It is generated by the action of cholesterol 7α hydroxylase on cholesterol in the liver. It is excreted in bile, which is then absorbed back into the body from the gut and used for energy metabolism. 7OHCD7 has been shown to be an inhibitor of histone deacetylases, which are enzymes that regulate gene transcription. This inhibition leads to increased transcriptional regulation and reduced inflammatory responses in bowel disease models. 7OHCD7 has also been shown to increase cholesterol levels and reduce inflammation in humans with metabolic syndrome.

Formula: C₂₇H₄₄O₂

Purezza: Min. 95%

Peso molecolare: 400.64 g/mol

Ref: 3D-FH58232

7α-Hydroxy-4-cholesten-3-one

CAS: 3862-25-7

Formula: C₂₇H₄₄O₂

Peso molecolare: 400.65

Ref: ST-EA-CP-C71043

7α-Hydroxy-4-cholesten-3-one

CAS: 3862-25-7

7α-Hydroxy-4-cholesten-3-one is a PXR agonist that can be used to study diseases associated with defects in bile acid biosynthesis.

Formula: C₂₇H₄₄O₂

Purezza: 99.14%

Colore e forma: White Solid

Peso molecolare: 400.64

Ref: TM-T10196