CAS 4016-63-1

8-Bromoguanosina

Descrizione:

8-Bromoguanosina è un nucleoside modificato che presenta un atomo di bromo sostituito nella posizione 8 della base della guanina. Questo composto è caratterizzato dai suoi componenti strutturali, che includono uno zucchero ribosio legato alla parte della guanina. La presenza dell'atomo di bromo può influenzare le proprietà biochimiche del composto, come la sua interazione con acidi nucleici ed enzimi. 8-Bromoguanosina è spesso utilizzato nella ricerca biochimica, in particolare negli studi che coinvolgono RNA e DNA, grazie alla sua capacità di imitare nucleosidi naturali fornendo al contempo reattività e caratteristiche di legame uniche. Può anche presentare proprietà di accoppiamento delle basi alterate, rendendolo uno strumento prezioso nell'indagine della struttura e della funzione degli acidi nucleici. Inoltre, la solubilità e la stabilità del composto in vari solventi possono variare, il che è importante per la sua applicazione in contesti di laboratorio. In generale, 8-Bromoguanosina funge da composto importante nel campo della biologia molecolare e della chimica medicinale.

Formula: C₁₀H₁₂BrN₅O₅

InChI: InChI=1S/C10H12BrN5O5/c11-9-13-3-6(14-10(12)15-7(3)20)16(9)8-5(19)4(18)2(1-17)21-8/h2,4-5,8,17-19H,1H2,(H3,12,14,15,20)/t2-,4-,5-,8-/m1/s1

InChI key: InChIKey=ASUCSHXLTWZYBA-UMMCILCDSA-N

SMILES: BrC=1N(C2=C(N1)C(=O)N=C(N)N2)[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O

Sinonimi:

• 2-Amino-8-bromo-9-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-purin-6-one
• 2-Amino-8-bromo-9-[3,4-dihydroxy-5-(hydroxymethyl)tetrahydro-2-furanyl]-1,9-dihydro-6H-purin-6-one
• 2-Amino-8-bromo-9-[3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-6,9-dihydro-1H-purin-6-one
• 2-amino-8-bromo-9-beta-D-glycero-pentofuranosyl-5,9-dihydro-6H-purin-6-one
• 2-amino-8-bromo-9-pentofuranosyl-3,9-dihydro-6H-purin-6-one
• 8-Bromo-Guanosine
• 8-Bromoguanosine hydrate
• Chembridge 5141604
• Guanosine, 8-bromo-
• NSC 174257
• NSC 79211

8-Bromoguanosine

CAS: 4016-63-1

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Sci

Formula: C₁₀H₁₂BrN₅O₅

Peso molecolare: 362.14

Ref: 02-J63940

Guanosine, 8-bromo-

CAS: 4016-63-1

Formula: C₁₀H₁₂BrN₅O₅

Purezza: 97%

Colore e forma: Solid

Peso molecolare: 362.1368

Ref: IN-DA00I7VO

2-amino-8-bromo-9-[3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-6,9-dihydro-1H-purin-6-one

CAS: 4016-63-1

2-amino-8-bromo-9-[3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-6,9-dihydro-1H-purin-6-one

Purezza: 98%

Peso molecolare: 362.14g/mol

Ref: 54-OR22747

8-Bromoguanosine

CAS: 4016-63-1

8-Bromoguanosine

Purezza: ≥95%

Peso molecolare: 362.14g/mol

Ref: 54-BUP17922

8-Bromoguanosine

CAS: 4016-63-1

8-Bromoguanosine

Purezza: 97%

Colore e forma: Solid

Peso molecolare: 362.14g/mol

Ref: 54-OR45116

8-Bromoguanosine

CAS: 4016-63-1

Formula: C₁₀H₁₂BrN₅O₅

Purezza: ≥ 98.0%

Colore e forma: White to off-white powder

Peso molecolare: 362.14

Ref: 7W-GE8230

8-Bromoguanosine

CAS: 4016-63-1

8-Bromoguanosine is a brominated derivative of guanosine. It is activate lymphocytes through an intracellular mechanism to exert immunostimulatory effects.

Formula: C₁₀H₁₂BrN₅O₅

Purezza: 97.26% - 99.62%

Colore e forma: White Solid

Peso molecolare: 362.14

Ref: TM-T7924

8-Bromoguanosine

CAS: 4016-63-1

8-Bromoguanosine (8BrG) is a potent inhibitor of cyclase enzymes that lead to the formation of cyclic guanosine monophosphate (cGMP). It has been shown to inhibit signal pathways, such as those regulated by the G protein-coupled receptor (GPCR), which are activated by the 2-adrenergic receptor. 8BrG has been shown to be effective against C. glabrata and other fungi and has been used in experimental models for infectious diseases.

Formula: C₁₀H₁₂BrN₅O₅

Purezza: Min. 95%

Colore e forma: White Powder

Peso molecolare: 362.14 g/mol

Ref: 3D-NB06311

8-Bromoguanosine

CAS: 4016-63-1

Formula: C₁₀H₁₂BrN₅O₅

Purezza: 97%

Colore e forma: Solid

Peso molecolare: 362.14

Ref: 10-F002895

8-Bromoguanosine-13C2,15N

Prodotto controllato

CAS: 4016-63-1

Applications 8-Bromoguanosine-13C2,15N is an intermediate in the synthesis of 8-Aminoguanosine-13C2,15N (A609877). 8-Aminoguanosine-13C2,15N is an isotopic labelled compound of 8-Aminoguanosine (A609875), which is a potent inhibitor of purine nucleoside phosphorylase.
References Kazmers, I.S., et al.: Science, 214, 1137 (1981); Chern, J-W., et al.: J. Med. Chem., 36, 1024 (1993)

Formula: C₂C₈H₁₂Br₁₅NN₄O₅

Colore e forma: Neat

Peso molecolare: 365.115

Ref: TR-B684366

8-Bromoguanosine

Prodotto controllato

CAS: 4016-63-1

Applications 8-Bromoguanosine (cas# 4016-63-1) is a compound useful in organic synthesis.
References Hu, H., et al.: Mol. Pharmacol., 69, 1542 (2006), Mallett, D., et al.: J. Pharm. Biomed. Anal., 49, 100 (2009),

Formula: C₁₀H₁₂BrN₅O₅

Colore e forma: Neat

Peso molecolare: 362.14

Ref: TR-B684365

8-Bromoguanosine-13C,15N2

Prodotto controllato

CAS: 4016-63-1

Applications 8-Bromoguanosine-13C,15N2 is a compound useful in organic synthesis.

Formula: C₉₁₃CH₁₂BrN₃₁₅N₂O₅

Colore e forma: Neat

Peso molecolare: 365.12

Ref: TR-B684367