CAS 402824-96-8

6-cloro-4-[[(6-cloro-1,1-diossido-3,4-diidro-2H-benzo[e][1,2,4]tiazina-7-il)sulfonilamino]metil]-1,1-diossido-2,3-diidrobenzo[e][1,2,4]tiazina-7-sulfonamide

Descrizione:

6-cloro-4-[[(6-cloro-1,1-diossido-3,4-diidro-2H-benzo[e][1,2,4]tiazina-7-il)sulfonilamino]metil]-1,1-diossido-2,3-diidrobenzo[e][1,2,4]tiazina-7-sulfonamide, con numero CAS 402824-96-8, è un composto organico complesso caratterizzato dalla sua struttura a più anelli e dalla presenza di gruppi funzionali sulfonamide e dioxo. Questo composto presenta un sostituente cloro, che contribuisce alla sua reattività e potenziale attività biologica. La presenza di anelli di tiadiazina suggerisce applicazioni potenziali in chimica medicinale, in particolare nello sviluppo di farmaci. Il gruppo sulfonamide è noto per le sue proprietà antibatteriche, indicando che questo composto potrebbe mostrare attività biologiche simili. La sua struttura intricata potrebbe anche influenzare la sua solubilità, stabilità e interazione con bersagli biologici. In generale, questo composto rappresenta una classe di composti eterociclici che potrebbero avere implicazioni significative nella scoperta e nello sviluppo di farmaci, in particolare nel targeting di enzimi o recettori specifici in diverse aree terapeutiche. Ulteriori studi sarebbero necessari per chiarire il suo comportamento chimico completo e le potenziali applicazioni.

Formula: C₁₅H₁₆Cl₂N₆O₈S₄

InChI: InChI=1/C15H16Cl2N6O8S4/c16-8-1-10-14(34(28,29)20-5-19-10)4-13(8)33(26,27)21-6-23-7-22-35(30,31)15-3-12(32(18,24)25)9(17)2-11(15)23/h1-4,19-22H,5-7H2,(H2,18,24,25)

SMILES: c1c(c(cc2c1NCNS2(=O)=O)S(=O)(=O)NCN1CNS(=O)(=O)c2cc(c(cc12)Cl)S(=O)(=O)N)Cl

Sinonimi:

• Hydrochlorothiazide EP Impurity C (Hydrochlorothiazide Dimer)
• Hydrochlorothiazide EP impurity C/ Dimer
• N-[[7-(Aminosulfonyl)-6-chloro-2,3-dihydro-1,1-dioxo-4H-1,2,4-benzothiadiazin-4-yl]methyl]-6-chloro-
• 6-chloro-4-[[(6-chloro-1,1-dioxo-3,4-dihydro-2H-1λ6,2,4-benzothiadiazin-7-yl)sulfonylamino]methyl]-1,1-dioxo-2,3-dihydro-1λ6,2,4-benzothiadiazine-7-sulfonamide
• N-[[7-(Aminosulfonyl)-6-chloro-2,3-dihydro-1,1-dioxo-4H-1,2,4-benzothiadiazin-4-yl]methyl]-6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-Dioxode
• 6
• ,2,4-benzothiadiazin-7-yl)sulfonylamino]methyl]-1,1-dioxo-2,3-dihydro-1λ
• N-[[7-(Aminosulfonyl)-6-chloro-2,3-dihydro-1,1-dioxo-4H-1,2,4-benzothiadiazin-4-yl]methyl]-6-chloro-3,4-dihydro-1,1-dioxo-2H-1,2,4-benzothiadiazine-7-sulfonamide
• Hydrochlorothiazide Impurity C
• 6-chloro-4-((6-chloro-1,1-dioxido-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamido)methyl)-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide 1,1-dioxide
• Hydrochlorothiazide IMpurity-C(EP)
• Hydrochlorothiazide Dimer
• 6-chloro-4-[[(6-chloro-1,1-dioxo-3,4-dihydro-2H-1λ
• HCTZ-CH2-HCTZ
• N-[[7-(Aminosulfonyl)-6-chloro-2,3-dihydro-1,1-dioxo-4H-1,2,4-benzothiadiazin-4-yl]methyl]-6-chloro-3,4-dihydro-1,1-dioxo-2H-1,2,4-benzothiadiazine-7-sulfonamide\nHydrochlorothiazide Impurity C:
• N-[[7-(Aminosulfonyl)-6-chloro-2,3-dihydro-1,1-dioxo-4H-1,2,4-benzothiadiazin-4-yl]methyl]-6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamid
• N-[[7-(Aminosulfonyl)-6-chloro-2,3-dihydro-1,1-dioxido-4H-1,2,4-benzothiadiazin-4-yl]methyl]-6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
• 2H-1,2,4-Benzothiadiazine-7-sulfonamide, N-[[7-(aminosulfonyl)-6-chloro-2,3-dihydro-1,1-dioxido-4H-1,2,4-benzothiadiazin-4-yl]methyl]-6-chloro-3,4-dihydro-, 1,1-dioxide
• 6-Chloro-N-[(6-chloro-7-sulfamoyl-2,3-dihydro-4H-1,2,4-benzothiadiazin-4-yl 1,1-dioxide)methyl]-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
• ,2,4-benzothiadiazine-7-sulfonamide

Hydrochlorothiazide Dimer (6-Chloro-4-({[(6-chloro-1,1-dioxido-3,4-dihydro-2H-1,2,4-benzothiadiazin-7-yl)sulfonyl]amino}methyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide)

CAS: 402824-96-8

Sulfonamides, nesoi

Formula: C₁₅H₁₆Cl₂N₆O₈S₄

Colore e forma: White Solid

Peso molecolare: 605.92895

Ref: 45-1A15670

N-[[7-(Aminosulfonyl)-6-chloro-2,3-dihydro-1,1-dioxo-4H-1,2,4-benzothiadiazin-4-yl]methyl]-6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-Dioxode

CAS: 402824-96-8

Formula: C₁₅H₁₆Cl₂N₆O₈S₄

Purezza: 95%

Colore e forma: Solid

Peso molecolare: 607.4889

Ref: IN-DA00C9HM

Hydrochlorothiazide EP Impurity C

CAS: 402824-96-8

Formula: C₁₅H₁₆Cl₂N₆O₈S₄

Colore e forma: White To Off-White Solid

Peso molecolare: 607.47

Ref: 4Z-H-054

HCTZ-CH2-HCTZ

CAS: 402824-96-8

HCTZ-CH2-HCTZ

Purezza: 98%

Ref: 54-OR1037135

Hydrochlorothiazide Impurity C

CAS: 402824-96-8

Impurity C in hydrochlorothiazide, a thiazide diuretic blocking NaCl cotransporter in kidneys.

Formula: C₁₅H₁₆Cl₂N₆O₈S₄

Colore e forma: Solid

Peso molecolare: 607.49

Ref: TM-T35728

6-Chloro-N-[(6-chloro-7-sulphamoyl-2,3-dihydro-4H-1,2,4-benzothiadiazin-4-yl 1,1-Dioxide)methyl]-3,4-dihydro-2H-1,2,4-benzothia-diazine-7-sulphonamide 1,1-Dioxide

CAS: 402824-96-8

Colore e forma: Neat

Ref: 86-MM0011.04

Hydrochlorothiazide Dimer

CAS: 402824-96-8

Impurity Hydrochlorothiazide EP Impurity C
Applications N-[[7-(Aminosulfonyl)-6-chloro-2,3-dihydro-1,1-dioxo-4H-1,2,4-benzothiadiazin-4-yl]methyl]-6-chloro-3,4-dihydro-1,1-dioxo-2H-1,2,4-benzothiadiazine-7-sulfonamide (Hydrochlorothiazide EP Impurity C) is an impurity in bulk Hydrochlorothiazide. Dimer Impurity C.
References Daniels, S.L., et al.: J. Pharm. Sci., 70, 211 (1981), Fang, X., et al.: Pharm. Res., 14, 691 (1997),

Formula: C₁₅H₁₆Cl₂N₆O₈S₄

Colore e forma: Off-White

Peso molecolare: 607.49

Ref: TR-A629375

Hydrochlorothiazide EP impurity C

CAS: 402824-96-8

Formula: C₁₅H₁₆Cl₂N₆O₈S₄

Peso molecolare: 607.47

Ref: ST-EA-CP-H3003

Hydrochlorothiazide impurity C

CAS: 402824-96-8

Hydrochlorothiazide is a sulfonamide that inhibits the activity of the enzyme, angiotensin-converting enzyme (ACE), which is responsible for converting angiotensin I to the potent vasoconstrictor, angiotensin II. It also has antihypertensive effects by blocking the production of aldosterone, which causes sodium retention and leads to high blood pressure. It is a byproduct in reactions with substances such as valsartan. Hydrochlorothiazide may react chemically with other medicines such as ampicillin and cefaclor.

Formula: C₁₅H₁₆Cl₂N₆O₈S₄

Purezza: Min. 95%

Colore e forma: White Powder

Peso molecolare: 607.49 g/mol

Ref: 3D-IA17850