CAS 4033-27-6

acido diidrofolico

Descrizione:

acido diidrofolico, noto anche come 7,8-diidrofolato, è un derivato della vitamina B solubile in acqua che svolge un ruolo cruciale nella sintesi degli acidi nucleici e degli aminoacidi. È un intermedio chiave nella via metabolica del folato, essenziale per la divisione e la crescita cellulare. acido diidrofolico è caratterizzato dalla sua struttura, che include un anello di pteridina, acido para-aminobenzoico e residui di acido glutammico. Questo composto si trova tipicamente nel corpo a seguito della riduzione dell'acido folico, facilitata dall'enzima diidrofolato reduttasi. È coinvolto nella conversione del folato alimentare nelle sue forme attive, necessarie per la sintesi e riparazione del DNA. acido diidrofolico è anche significativo in farmacologia, poiché alcuni antibiotici, come le sulfonamidi, inibiscono la sua sintesi nei batteri, esercitando così i loro effetti antimicrobici. Il suo numero CAS, 4033-27-6, è utilizzato per l'identificazione in database chimici e contesti normativi. In generale, acido diidrofolico è vitale per mantenere le funzioni cellulari adeguate e la salute complessiva.

Formula: C₁₉H₂₁N₇O₆

InChI: InChI=1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/t12-/m0/s1

InChI key: InChIKey=OZRNSSUDZOLUSN-LBPRGKRZSA-N

SMILES: O=C1C2=C(NCC(CNC3=CC=C(C(N[C@@H](CCC(O)=O)C(O)=O)=O)C=C3)=N2)NC(N)=N1

Sinonimi:

• 7,8-Dihydro-<span class="text-smallcaps">L</span>-folic acid
• 7,8-Dihydrofolic acid
• <span class="text-smallcaps">L</span>-Glutamic acid, N-[4-[[(2-amino-1,4,7,8-tetrahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-
• <span class="text-smallcaps">L</span>-Glutamic acid, N-[4-[[(2-amino-3,4,7,8-tetrahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-
• Dihydrofolate
• Glutamic acid, N-[p-[[(2-amino-7,8-dihydro-4-hydroxy-6-pteridinyl)methyl]amino]benzoyl]-, <span class="text-smallcaps">L</span>-
• L-Glutamic acid, N-(4-(((2-amino-1,4,7,8-tetrahydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)- (9CI)
• N-(4-{[(2-amino-4-oxo-1,4,7,8-tetrahydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
• N-(4-{[(2-amino-4-oxo-1,4,7,8-tetrahydropteridin-6-yl)methyl]amino}benzoyl)glutamic acid
• N-[4-[[(2-Amino-3,4,7,8-tetrahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-<span class="text-smallcaps">L</span>-glutamic acid
• Nsc 165989
• L-Glutamic acid, N-[4-[[(2-amino-1,4,7,8-tetrahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-
• L-Glutamic acid, N-[4-[[(2-amino-3,4,7,8-tetrahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-
• Dihydrofolic acid
• Glutamic acid, N-[p-[[(2-amino-7,8-dihydro-4-hydroxy-6-pteridinyl)methyl]amino]benzoyl]-, L-
• N-[4-[[(2-Amino-3,4,7,8-tetrahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid
• 7,8-Dihydropteroyl-L-glutaMic acid
• (S)-2-(4-(((2-aMino-4-oxo-1,4,7,8-tetrahydropteridin-6-yl)Methyl)aMino)benzaMido)pentanedioic acid
• Folic acid impurity 2/Folinic Acid EP Impurity G/Dihydrofolic acid/7,8-Dihydrofolic Acid
• Folinic Acid Impurity G (7,8-Dihydrofolic Acid)
• 7,8-Dihydropteroyl-L-glutamic acid, Dihydropteroyl-L-glutamic acid, FAH2
• Levofolinate EP Impurity G
• Folinic Acid EP Impurity G (7,8-Dihydrofolic Acid)
• 2-[4-[(2-amino-4-oxo-7,8-dihydro-1H-pteridin-6-yl)methylamino]benzoyl]aminopentanedioic acid
• N-[4-[[[(2-Amino-1,4,5,6-tetrahydro-4-oxopteridin)-6-yl]methyl]amino]benzoyl]-L-glutamic acid
• Impurity G of Calcium Levofolinate
• Folic Acid 7,8-Dihydro Impurity
• FAH2
• 7,8-DIHYDROPTEROYL-L-GLUTAMIC ACID
• DIHYDROPTEROYL-L-GLUTAMIC ACID
• Folinic Acid EP Impurity G

Dihydrofolic acid

CAS: 4033-27-6

Formula: C₁₉H₂₁N₇O₆

Purezza: 90%

Colore e forma: Solid

Peso molecolare: 443.4133

Ref: IN-DA003PJ0

(S)-2-(4-(((2-Amino-4-oxo-3,4,7,8-tetrahydropteridin-6-yl)methyl)amino)benzamido)pentanedioic acid

CAS: 4033-27-6

(S)-2-(4-(((2-Amino-4-oxo-3,4,7,8-tetrahydropteridin-6-yl)methyl)amino)benzamido)pentanedioic acid

Purezza: 90%

Peso molecolare: 443.42g/mol

Ref: 54-OR1074661

Dihydrofolic acid

CAS: 4033-27-6

Formula: C₁₉H₂₁N₇O₆

Purezza: ≥ 90.0%

Colore e forma: Off-white to beige or grey solid

Peso molecolare: 443.41

Ref: 7W-GV4745

Dihydrofolic acid

CAS: 4033-27-6

Dihydrofolic acid (7,8-Dihydrofolic acid) is a folic acid derivative that produces tetrahydrofolic acid in the presence of dihydrofolic acid reductase.

Formula: C₁₉H₂₁N₇O₆

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 443.41

Ref: TM-T15128

Dihydro Folic Acid

CAS: 4033-27-6

Stability Hygroscoipic, Light and Air Sensitive
Applications Dihydrofolic Acid is an intermediate in mammalian conversion of dietary folic acid to tetrahydrofolate by dihydrofolate reductase (DHFR). Folic acid (FA) and Dihydrofolic acid (FAH2) are substrates of dihydrofolate reductase(s) which reduce them to tetrahydrofolate (THF).
References Andres, J., et al.: Bioorg. Chem., 24, 10 (1996), Benkovic, S., et al.: Science, 301, 1196 (2003), ,,,,Williams, D; J Mol Biol 2003, 329, 389,,,Krahn, J., et al.: Biochemistry, 46, 14878 (2007),

Formula: C₁₉H₂₁N₇O₆

Colore e forma: Light Beige To Grey

Peso molecolare: 443.41

Ref: TR-D449700

Levofolinate EP Impurity G

CAS: 4033-27-6

Formula: C₁₉H₂₁N₇O₆

Peso molecolare: 443.4

Ref: ST-EA-CP-L57007

Dihydrofolic acid

CAS: 4033-27-6

Dihydrofolic acid is an organic compound that is a derivative of folic acid. It is the reduced form of folic acid and can be used to treat certain autoimmune diseases, such as bowel disease. Dihydrofolic acid has been shown to have antimicrobial effects against infectious diseases, including tuberculosis. This compound can also be used to treat metal-chelate resistant bacteria, such as methicillin-resistant Staphylococcus aureus (MRSA). Dihydrofolic acid has been shown to have neuroprotective properties in animals models and may be a potential drug target for the treatment of Alzheimer's disease.

Formula: C₁₉H₂₁N₇O₆

Purezza: (%) Min. 90%

Colore e forma: Powder

Peso molecolare: 443.41 g/mol

Ref: 3D-FD170209

Dihydro Folic Acid-D4 (Technical Grade)

Prodotto controllato

CAS: 4033-27-6

Formula: C₁₉D₄H₁₇N₇O₆

Colore e forma: Neat

Peso molecolare: 447.438

Ref: TR-D449702

7,8-Dihydrofolic Acid ((4-(((2-amino-4-oxo-3,4,7,8-tetrahydropteridin-6-yl)methyl)amino)benzoyl)-L-glutamic acid)

CAS: 4033-27-6

Compounds containing a pyrimidine ring, whether or not hydrogenated, or piperazine ring in the structure, nesoi

Formula: C₁₉H₂₁N₇O₆

Colore e forma: Brown Solid

Peso molecolare: 443.15533

Ref: 45-1A06330