CAS 40505-27-9
:4′-Desmetilpodofilotossina
Descrizione:
4′-Desmetilpodofilotossina è un composto chimico derivato dalla specie vegetale Podophyllum peltatum, comunemente noto come mayapple. È classificato come un lignano, che è un tipo di composto polifenolico. Questa sostanza è caratterizzata dalle sue caratteristiche strutturali, inclusa una struttura di dibenzilbutirolattone, che contribuisce alla sua attività biologica. 4′-Desmetilpodofilotossina mostra proprietà antitumorali ed è stato studiato per il suo potenziale utilizzo nella terapia del cancro, in particolare per la sua capacità di inibire la divisione cellulare interferendo con il fuso mitotico. Il composto è anche noto per il suo ruolo come precursore nella sintesi di altri derivati farmacologicamente attivi. In termini di solubilità, è generalmente più solubile nei solventi organici che in acqua, il che può influenzare la sua biodisponibilità e le applicazioni terapeutiche. Come molti prodotti naturali, i processi di estrazione e purificazione possono influenzare il suo rendimento e la sua potenza, rendendolo un'area di interesse per ulteriori ricerche in chimica medicinale e farmacologia.
Formula:C21H20O8
InChI:InChI=1/C21H20O8/c1-25-15-3-9(4-16(26-2)20(15)23)17-10-5-13-14(29-8-28-13)6-11(10)19(22)12-7-27-21(24)18(12)17/h3-6,12,17-19,22-23H,7-8H2,1-2H3/t12-,17+,18-,19-/m0/s1
InChI key:InChIKey=YVCVYCSAAZQOJI-BTINSWFASA-N
SMILES:O=C1[C@@]2([C@@H](C=3C([C@H](O)[C@]2(CO1)[H])=CC4=C(C3)OCO4)C5=CC(OC)=C(O)C(OC)=C5)[H]
Sinonimi:- (5R,5aR,8aR,9R)-5,8,8a,9-Tetrahydro-9-hydroxy-5-(4-hydroxy-3,5-dimethoxyphenyl)furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one
- (5R,5aR,8aR,9R)-9-hydroxy-5-(4-hydroxy-3,5-dimethoxyphenyl)-5,8,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one
- 4′-O-Demethylpodophyllotoxin
- 9-Hydroxy-5-(4-hydroxy-3,5-dimethoxyphenyl)-5,8,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one
- Furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-9-hydroxy-5-(4-hydroxy-3,5-dimethoxyphenyl)-, (5R,5aR,8aR,9R)-
- Furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-9-hydroxy-5-(4-hydroxy-3,5-dimethoxyphenyl)-, [5R-(5α,5aβ,8aα,9α)]-
- Podophyllotoxin, 4′-demethyl-
- 4′-Demethylpodophyllotoxin
- Furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-9-hydroxy-5-(4-hydroxy-3,5-dimethoxyphenyl)-, (5R,5aR,8aR,9R)-
- (5R,5AR,8aR,9R)-9-hydroxy-5-(4-hydroxy-3,5-dimethoxyphenyl)-5,5a,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(8H)-one
- 4'-Demethylpodophyllotoxin USP/EP/BP
- (5R)-5β-(4-Hydroxy-3,5-dimethoxyphenyl)-9β-hydroxy-5,5aα,6,8,8aβ,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d]-1,3-dioxole-6-one
- (5R)-5,8,8aβ,9-Tetrahydro-5β-(3,5-dimethoxy-4-hydroxyphenyl)-9β-hydroxyfuro[3',4':6,7]naphtho[2,3-d]-1,3-dioxole-6(5aαH)-one
- 5-hydroxy-9-(4-hydroxy-3,5-dimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-isobenzofuro[5,6-f][1,3]benzodioxol-8-one
- (5R)-5,8,8aβ,9-Tetrahydro-9β-hydroxy-5β-(3,5-dimethoxy-4-hydroxyphenyl)furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aαH)-one
- Vedi altri sinonimi
Ordinare per
Purezza (%)
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100
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90
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95
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100
10 prodotti.
(5R,5aR,8aR,9R)-9-Hydroxy-5-(4-hydroxy-3,5-dimethoxyphenyl)-5,5a,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(8H)-one
CAS:Purezza:97.0%Peso molecolare:400.38299560546875Ref: 4Z-P-122001
5mgPrezzo su richiesta10mgPrezzo su richiesta25mgPrezzo su richiesta50mgPrezzo su richiesta100mgPrezzo su richiesta4'-Demethylpodophyllotoxin
CAS:4'-Demethylpodophyllotoxin is isolated from the herb of Dysosma pleiantha (Hance) Woodson with remarkable cytotoxic potential in diverse cancer cell lines.Formula:C21H20O8Purezza:99.27% - 99.60%Colore e forma:SolidPeso molecolare:400.38Ref: ST-EA-CP-E31011
10mgPrezzo su richiesta25mgPrezzo su richiesta50mgPrezzo su richiesta100mgPrezzo su richiesta4'-Demethylpodophyllotoxin
CAS:4'-Demethylpodophyllotoxin is a lignan derivative, which is sourced primarily from the roots and rhizomes of the plant species Podophyllum. This compound is a refined version of podophyllotoxin, a well-known precursor in the synthesis of anticancer drugs. The primary mode of action of 4'-Demethylpodophyllotoxin involves the inhibition of microtubule assembly, thereby disrupting the mitotic spindle formation essential for cell division. This mechanism leads to cell cycle arrest and apoptosis in rapidly dividing cells, highlighting its potential in antitumor therapies.
Formula:C21H20O8Purezza:Min. 95%Colore e forma:PowderPeso molecolare:400.38 g/mol4’-Demethylpodophyllotoxin
CAS:Prodotto controllatoApplications 4’-Demethylpodophyllotoxin is a lignan studied for its content in different parts of Sinopodophyllum hexandrum.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Li, Y-L., et al.: Zhongguo Zhongyao Zazhi, 40, 1837-1841 (2015)Formula:C21H20O8Colore e forma:NeatPeso molecolare:400.38
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