CAS 40505-27-9

4′-Desmetilpodofilotossina

Descrizione:

4′-Desmetilpodofilotossina è un composto chimico derivato dalla specie vegetale Podophyllum peltatum, comunemente noto come mayapple. È classificato come un lignano, che è un tipo di composto polifenolico. Questa sostanza è caratterizzata dalle sue caratteristiche strutturali, inclusa una struttura di dibenzilbutirolattone, che contribuisce alla sua attività biologica. 4′-Desmetilpodofilotossina mostra proprietà antitumorali ed è stato studiato per il suo potenziale utilizzo nella terapia del cancro, in particolare per la sua capacità di inibire la divisione cellulare interferendo con il fuso mitotico. Il composto è anche noto per il suo ruolo come precursore nella sintesi di altri derivati farmacologicamente attivi. In termini di solubilità, è generalmente più solubile nei solventi organici che in acqua, il che può influenzare la sua biodisponibilità e le applicazioni terapeutiche. Come molti prodotti naturali, i processi di estrazione e purificazione possono influenzare il suo rendimento e la sua potenza, rendendolo un'area di interesse per ulteriori ricerche in chimica medicinale e farmacologia.

Formula: C₂₁H₂₀O₈

InChI: InChI=1/C21H20O8/c1-25-15-3-9(4-16(26-2)20(15)23)17-10-5-13-14(29-8-28-13)6-11(10)19(22)12-7-27-21(24)18(12)17/h3-6,12,17-19,22-23H,7-8H2,1-2H3/t12-,17+,18-,19-/m0/s1

InChI key: InChIKey=YVCVYCSAAZQOJI-BTINSWFASA-N

SMILES: O=C1[C@@]2([C@@H](C=3C([C@H](O)[C@]2(CO1)[H])=CC4=C(C3)OCO4)C5=CC(OC)=C(O)C(OC)=C5)[H]

Sinonimi:

• (5R,5aR,8aR,9R)-5,8,8a,9-Tetrahydro-9-hydroxy-5-(4-hydroxy-3,5-dimethoxyphenyl)furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one
• (5R,5aR,8aR,9R)-9-hydroxy-5-(4-hydroxy-3,5-dimethoxyphenyl)-5,8,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one
• 4′-O-Demethylpodophyllotoxin
• 9-Hydroxy-5-(4-hydroxy-3,5-dimethoxyphenyl)-5,8,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one
• Furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-9-hydroxy-5-(4-hydroxy-3,5-dimethoxyphenyl)-, (5R,5aR,8aR,9R)-
• Furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-9-hydroxy-5-(4-hydroxy-3,5-dimethoxyphenyl)-, [5R-(5α,5aβ,8aα,9α)]-
• Podophyllotoxin, 4′-demethyl-
• 4′-Demethylpodophyllotoxin
• Furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-9-hydroxy-5-(4-hydroxy-3,5-dimethoxyphenyl)-, (5R,5aR,8aR,9R)-
• (5R,5AR,8aR,9R)-9-hydroxy-5-(4-hydroxy-3,5-dimethoxyphenyl)-5,5a,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(8H)-one
• 4'-Demethylpodophyllotoxin USP/EP/BP
• (5R)-5β-(4-Hydroxy-3,5-dimethoxyphenyl)-9β-hydroxy-5,5aα,6,8,8aβ,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d]-1,3-dioxole-6-one
• (5R)-5,8,8aβ,9-Tetrahydro-5β-(3,5-dimethoxy-4-hydroxyphenyl)-9β-hydroxyfuro[3',4':6,7]naphtho[2,3-d]-1,3-dioxole-6(5aαH)-one
• 5-hydroxy-9-(4-hydroxy-3,5-dimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-isobenzofuro[5,6-f][1,3]benzodioxol-8-one
• (5R)-5,8,8aβ,9-Tetrahydro-9β-hydroxy-5β-(3,5-dimethoxy-4-hydroxyphenyl)furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aαH)-one

Etoposide EP Impurity L

CAS: 40505-27-9

Formula: C₂₁H₂₀O₈

Peso molecolare: 400.38

Ref: 4Z-E-598

4'-Demethylpodophyllotoxin

CAS: 40505-27-9

4'-Demethylpodophyllotoxin

Purezza: ≥98%

Peso molecolare: 400.38g/mol

Ref: 54-BUP06286

(5R,5aR,8aR,9R)-9-Hydroxy-5-(4-hydroxy-3,5-dimethoxyphenyl)-5,5a,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(8H)-one

CAS: 40505-27-9

Purezza: 97.0%

Peso molecolare: 400.38299560546875

Ref: 10-F545202

4'-Demethylpodophyllotoxin

CAS: 40505-27-9

Formula: C₂₁H₂₀O₈

Purezza: 95%~99%

Peso molecolare: 400.383

Ref: BP-BP0076

Podophyllotoxin Impurity 1

CAS: 40505-27-9

Formula: C₂₁H₂₀O₈

Peso molecolare: 400.38

Ref: 4Z-P-122001

4'-Demethylpodophyllotoxin

CAS: 40505-27-9

4'-Demethylpodophyllotoxin is isolated from the herb of Dysosma pleiantha (Hance) Woodson with remarkable cytotoxic potential in diverse cancer cell lines.

Formula: C₂₁H₂₀O₈

Purezza: 99.27% - 99.60%

Colore e forma: Solid

Peso molecolare: 400.38

Ref: TM-T2S0029

Etoposide EP Impurity L

CAS: 40505-27-9

Formula: C₂₁H₂₀O₈

Peso molecolare: 400.4

Ref: ST-EA-CP-E31011

4'-Demethylpodophyllotoxin

CAS: 40505-27-9

4'-Demethylpodophyllotoxin is a lignan derivative, which is sourced primarily from the roots and rhizomes of the plant species Podophyllum. This compound is a refined version of podophyllotoxin, a well-known precursor in the synthesis of anticancer drugs. The primary mode of action of 4'-Demethylpodophyllotoxin involves the inhibition of microtubule assembly, thereby disrupting the mitotic spindle formation essential for cell division. This mechanism leads to cell cycle arrest and apoptosis in rapidly dividing cells, highlighting its potential in antitumor therapies.

Formula: C₂₁H₂₀O₈

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 400.38 g/mol

Ref: 3D-FD40476

4'-Demethylpodophyllotoxin

CAS: 40505-27-9

Formula: C₂₁H₂₀O₈

Colore e forma: Solid

Peso molecolare: 400.3787

Ref: IN-DA003ARU

4’-Demethylpodophyllotoxin

Prodotto controllato

CAS: 40505-27-9

Applications 4’-Demethylpodophyllotoxin is a lignan studied for its content in different parts of Sinopodophyllum hexandrum.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Li, Y-L., et al.: Zhongguo Zhongyao Zazhi, 40, 1837-1841 (2015)

Formula: C₂₁H₂₀O₈

Colore e forma: Neat

Peso molecolare: 400.38

Ref: TR-D231218