CAS 4146-30-9

Solfato di neomicina B

Descrizione:

Solfato di neomicina B è un antibiotico aminoglicosidico derivato dal batterio *Streptomyces fradiae*. Viene utilizzato principalmente per le sue proprietà antibatteriche, in particolare contro i batteri Gram-negativi. La sostanza è caratterizzata dalla sua struttura complessa, che include più zuccheri amino legati a un anello di aminociclitolo centrale. Solfato di neomicina B è altamente solubile in acqua, rendendolo adatto per varie formulazioni farmaceutiche, comprese applicazioni topiche e oftalmiche. Presenta un ampio spettro di attività, risultando particolarmente efficace contro le infezioni causate da *Escherichia coli* e *Klebsiella pneumoniae*. Tuttavia, il suo uso è spesso limitato a causa della potenziale nefrotossicità e ototossicità, specialmente con somministrazione sistemica. Solfato di neomicina B è anche utilizzato in ambienti di laboratorio per l'inibizione selettiva della crescita batterica. Il suo meccanismo d'azione implica il legame al ribosoma batterico, interrompendo la sintesi proteica, il che porta infine alla morte cellulare. Come per tutti gli antibiotici, un uso appropriato è cruciale per mitigare il rischio di sviluppare resistenza agli antibiotici.

Formula: C₂₃H₄₆N₆O₁₃·3H₂O₄S

InChI: InChI=1S/C23H46N6O13.H2O4S/c24-2-7-13(32)15(34)10(28)21(37-7)40-18-6(27)1-5(26)12(31)20(18)42-23-17(36)19(9(4-30)39-23)41-22-11(29)16(35)14(33)8(3-25)38-22;1-5(2,3)4/h5-23,30-36H,1-4,24-29H2;(H2,1,2,3,4)/t5-,6+,7-,8+,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+;/m1./s1

InChI key: InChIKey=OIXVKQDWLFHVGR-WQDIDPJDSA-N

SMILES: S(=O)(=O)(O)O.O([C@H]1[C@H](O[C@H]2[C@H](O)[C@H](O[C@H]3O[C@@H](CN)[C@@H](O)[C@H](O)[C@H]3N)[C@@H](CO)O2)[C@@H](O)[C@H](N)C[C@@H]1N)[C@H]4O[C@H](CN)[C@@H](O)[C@H](O)[C@H]4N

Sinonimi:

• (1R,2R,3S,4R,6S)-4,6-diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-beta-D-idopyranosyl)-beta-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2,6-diamino-2,6-dideoxy-alpha-D-glucopyranoside sulfate (salt)
• <span class="text-smallcaps">D</smallcap>-Streptamine, O-2,6-diamino-2,6-dideoxy-β-<smallcap>L</smallcap>-idopyranosyl-(1→3)-O-β-<smallcap>D</smallcap>-ribofuranosyl-(1→5)-O-[2,6-diamino-2,6-dideoxy-α-<smallcap>D</span>-glucopyranosyl-(1→4)]-2-deoxy-, sulfate (1:3)
• <span class="text-smallcaps">D</smallcap>-Streptamine, O-2,6-diamino-2,6-dideoxy-β-<smallcap>L</smallcap>-idopyranosyl-(1→3)-O-β-<smallcap>D</smallcap>-ribofuranosyl-(1→5)-O-[2,6-diamino-2,6-dideoxy-α-<smallcap>D</span>-glucopyranosyl-(1→4)]-2-deoxy-, sulfate (1:3) (salt)
• Neomycin B sulfate
• Neomycin B trisulfate
• Neomycin B, sulfate (1:3) (salt)
• D-Streptamine, O-2,6-diamino-2,6-dideoxy-β-L-idopyranosyl-(1→3)-O-β-D-ribofuranosyl-(1→5)-O-[2,6-diamino-2,6-dideoxy-α-D-glucopyranosyl-(1→4)]-2-deoxy-, sulfate (1:3)
• D-Streptamine, O-2,6-diamino-2,6-dideoxy-β-L-idopyranosyl-(1→3)-O-β-D-ribofuranosyl-(1→5)-O-[2,6-diamino-2,6-dideoxy-α-D-glucopyranosyl-(1→4)]-2-deoxy-, sulfate (1:3) (salt)

FRAMYCETIN SULFATE CRS

CAS: 4146-30-9

FRAMYCETIN SULFATE CRS

Formula: C₂₃H₄₈N₆O₁₇S

Peso molecolare: 712.7222

Ref: 41-F0450000

FRAMYCETIN SULFATE (NEOMYCIN B SULFATE) RS

CAS: 4146-30-9

FRAMYCETIN SULFATE (NEOMYCIN B SULFATE) RS

Ref: 41-ICRS0355

D-STREPTAMINE, O-2,6-DIAMINO-2,6-DIDEOXY-β-L-IDOPYRANOSYL-(1->3)-O-β-D-RIBOFURANOSYL-(1->5)-O-[2,6-DIAMINO-2,6-DIDEOXY-A-D-GLUCOPYRANOSYL-(1->4)]-2-DEOXY-, SULFATE (1:3)

CAS: 4146-30-9

Formula: C₂₃H₅₂N₆O₂₅S₃

Purezza: 97%

Colore e forma: Solid

Peso molecolare: 908.8792

Ref: IN-DA00BZ3H

Framycetin sulfate

CAS: 4146-30-9

Framycetin sulfate (Neomycin Sulphate B) belongs to aminoglycoside class of antibiotics that contain two or more aminosugars connected by glycosidic bonds.

Formula: C₂₃H₅₂N₆O₂₅S₃

Purezza: 99.79% - 99.89%

Colore e forma: White To Yellowish Powder

Peso molecolare: 908.86

Ref: TM-T2096

Framycetin sulfate, BP, Ph. Eur. grade

CAS: 4146-30-9

Formula: C₂₃H₄₆N₆O₁₃·3H₂SO₄·xH₂O

Purezza: ≤ 3.0%

Colore e forma: White or pale yellow crystalline powder

Peso molecolare: 712.72 (anhydrous)

Ref: 7W-GA7318

Framycetin sulfate

CAS: 4146-30-9

Framycetin sulfate

Purezza: ≥98%

Peso molecolare: 712.22g/mol

Ref: 54-BUP17823

Neomycin B Trisulfate (Framycetin Trisulfate)

CAS: 4146-30-9

Formula: C₂₃H₄₆N₆O₁₃·3H₂SO₄

Colore e forma: Off-White Solid

Peso molecolare: 614.65 3*98.08

Ref: 4Z-N-080009

Framycetin sulfate

CAS: 4146-30-9

Formula: C₂₃H₄₆N₆O₁₃·3H₂SO₄·xH₂O

Purezza: ≥ 600IU/mg (dried basis)

Colore e forma: White to pale yellow powder

Peso molecolare: 712.72 (anhydrous)

Ref: 7W-GA3510

Neomycin B Trisulfate

CAS: 4146-30-9

Formula: C₂₃H₄₆N₆O₁₃(H₂SO₄)

Peso molecolare: 614.65 : 3(98.07)

Ref: ST-EA-CP-N53013

Framycetin sulphate

CAS: 119-04-0, 28002-70-2, 4146-30-9

Framycetin sulphate is a broad-spectrum antibiotic that is used to treat microbial infections. It has been shown to be effective against many gram-positive and gram-negative bacteria, including methicillin resistant Staphylococcus aureus. Framycetin sulphate prevents bacterial growth by inhibiting protein synthesis through binding to the 30S ribosomal subunit. This binding inhibits the incorporation of amino acids into proteins, thereby preventing the production of new proteins required for cell division and growth. Framycetin sulphate also has preservative properties, which may be due to its ability to chelate metal ions such as copper and iron. Framycetin sulphate can be administered orally or topically in vivo model studies. The drug was not found to have any significant toxic effects on the liver or kidneys in vivo model studies at concentrations up to 40%.

Formula: C₂₃H₅₂N₆O₂₅S₃

Purezza: Min. 95%

Peso molecolare: 908.88 g/mol

Ref: 3D-FF150536