CAS 42228-92-2
:Acivicina
Descrizione:
Acivicina è un composto chimico classificato come un potente inibitore dell'enzima glutamina sintetasi, che svolge un ruolo cruciale nel metabolismo dell'azoto. È un analogo di aminoacido che si verifica naturalmente ed è derivato da fonti microbiche. Acivicina presenta una struttura unica che gli consente di imitare la glutamina, interferendo così con le sue normali funzioni metaboliche. Questa inibizione può portare a effetti significativi sui processi cellulari, rendendo Acivicina di interesse nella ricerca sul cancro e in potenziali applicazioni terapeutiche. Il composto è stato studiato per la sua capacità di indurre apoptosi in alcune linee cellulari tumorali, evidenziando il suo potenziale come agente anticancro. Inoltre, Acivicina ha mostrato promesse nella modulazione delle risposte immunitarie, ampliando ulteriormente le sue potenziali applicazioni in medicina. Tuttavia, il suo utilizzo è limitato dalla tossicità e dagli effetti collaterali, richiedendo una considerazione attenta nei contesti terapeutici. In generale, Acivicina rappresenta uno strumento prezioso nella ricerca biochimica e nello sviluppo di farmaci, in particolare nei campi dell'oncologia e dell'immunologia.
Formula:C5H7ClN2O3
InChI:InChI=1S/C5H7ClN2O3/c6-3-1-2(11-8-3)4(7)5(9)10/h2,4H,1,7H2,(H,9,10)/t2-,4-/m0/s1
InChI key:InChIKey=QAWIHIJWNYOLBE-OKKQSCSOSA-N
SMILES:[C@H](C(O)=O)(N)[C@]1(ON=C(Cl)C1)[H]
Sinonimi:- (2S)-amino[(5S)-3-chloro-4,5-dihydro-1,2-oxazol-5-yl]ethanoic acid
- (S-(R*,R*))-4,5-Dihydro-alpha-amino-3-chloro-5-isoxazoleacetic acid
- (alpha-S,5S)-alpha-Amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid
- (alphaS,5S)-alpha-Amino-3-chlor-4,5-dihydro-5-isoxazolylessigsaeure
- (alphaS,5S)-alpha-Amino-3-chloro-2-isoxazoline-5-acetic acid
- (α-S, 5S)-α-Amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid
- (αS,5S)-α-Amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid
- 5-Isoxazoleacetic acid, 4,5-dihydro-alpha-amino-3-chloro-, (S-(R*,R*))-
- 5-Isoxazoleacetic acid, alpha-amino-3-chloro-4,5-dihydro-
- 5-Isoxazoleacetic acid, alpha-amino-3-chloro-4,5-dihydro-, (S-(R*,R*))-
- 5-Isoxazoleacetic acid, α-amino-3-chloro-4,5-dihydro-, (αS,5S)-
- 5-Isoxazoleacetic acid, α-amino-3-chloro-4,5-dihydro-, [S-(R*,R*)]-
- Acivicin [USAN:INN]
- Acivicine
- Acivicine [INN-French]
- Acivicino
- Acivicino [INN-Spanish]
- Acivicinum
- Acivicinum [INN-Latin]
- Amino(3-Chloro-4,5-Dihydro-1,2-Oxazol-5-Yl)Acetic Acid
- Antibiotic AT 125
- At 125
- Brn 1074648
- Nsc 163501
- U 42126
- Unii-O0X60K76I6
- Acivicin
- ALPHA-AMINO-3-CHLORO-4,5-DIHYDRO-5-ISOXAZOLEACETIC ACID
- (s-(r*,r*))-4,5-dihydro-alpha-amino-3-chloro-5-isoxazoleaceticacid
- (alpha-s,5s)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleaceticacid
- (5S,αS)-α-Amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid
- antibioticat125
- AMINO-3-CHLORO-4,5-DIHYDROXY-5-ISOXAZOLEACETICACID
- (αS,5S)-
- Antibiotic U-42126
- (2S)-2-Amino-2-[(5S)-3-chloro-4,5-dihydroisoxazol-5-Yl]acetic acid
- DIHYDROXY-5-ISOXAZOLEACETICACID
- 4,5-dihydro-alpha-amino-3-chloro-,(s-(r*,r*))-5-isoxazoleaceticaci
- AcivicinAcivicin
- Vedi altri sinonimi
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7 prodotti.
Acivicin, 98+%
CAS:<p>Inhibits glutamine amidotransferases in purine and pyrimidine synthetic pathways. Tumor growth inhibitor This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa A</p>Formula:C5H7ClN2O3Purezza:98+%Colore e forma:White to off-white, PowderPeso molecolare:178.57Acivicin
CAS:Acivicin (AT-125) is a chlorinated amino acid antibiotic produced by Streptomyces porcineus, a GGT inhibitor with anticancer and antiparasitic activity.Formula:C5H7ClN2O3Purezza:98%Colore e forma:SolidPeso molecolare:178.57Acivicin
CAS:Prodotto controllato<p>Applications Azaserine and Acivicin are classical and irreversible inhibitors of γ-Glutamyltranspeptidase (GGT). Acivicin is a potent antitumor antibiotic that induces apoptosis in human lymphoblastoid cells.<br>References Hanigan, M., et al.: Biochemistry, 32, 6302 (1993); Suzuki, H., et al.: J. Bacteriol., 175, 6038 (1993); Suzuki, H., et al.: J. Biol. Chem., 277, 43536 (2002); Magdalena, L., et al.: Biochem. Pharma., 77, 76 (2009)<br></p>Formula:C5H7ClN2O3Colore e forma:Off White SolidPeso molecolare:178.57(2S)-2-Amino-2-[(5S)-3-chloro-4,5-dihydroisoxazol-5-Yl]acetic acid
CAS:<p>(2S)-2-Amino-2-[(5S)-3-chloro-4,5-dihydroisoxazol-5-Yl]acetic acid is an inhibitor of the enzyme glutathione reductase (GR) and cytochrome P450. GR activates glutathione in cells to form a powerful antioxidant that protects against oxidative stress. (2S)-2-Amino-2-[(5S)-3-chloro-4,5-dihydroisoxazol-5-Yl]acetic acid inhibits GR and cytochrome P450 activity, leading to increased oxidative stress and neuronal death. This drug has been shown to have inhibitory properties on bowel disease by reducing the production of proinflammatory cytokines IL1β and TNFα. The compound also exhibits anti tumor response against mouse tumors by inducing apoptosis and inhibiting cell proliferation. The compound targets intracellular targets</p>Formula:C5H7ClN2O3Purezza:Min. 95%Colore e forma:White PowderPeso molecolare:178.57 g/mol
![(2S)-2-Amino-2-[(5S)-3-chloro-4,5-dihydroisoxazol-5-Yl]acetic acid](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2F3D%2Fthumb%2FFA17203.jpg&w=3840&q=75)
