CAS 42267-27-6

N-trifluoroacetil-L-lisina N-carbossianidride

Descrizione:

N-trifluoroacetil-L-lisina N-carbossianidride (CAS 42267-27-6) è un composto chimico che appartiene alla classe degli N-carbossianidridi (NCA), che sono intermediari importanti nella sintesi di polipeptidi e proteine. Questo composto presenta un gruppo trifluoroacetile, che ne aumenta la reattività e la solubilità nei solventi organici. La presenza del residuo di lisina contribuisce al suo potenziale di formare legami peptidici, rendendolo utile nella chimica dei polimeri e nella biochimica. N-trifluoroacetil-L-lisina N-carbossianidride è tipicamente caratterizzato dalla sua stabilità in condizioni anidre e dalla sua capacità di subire polimerizzazione in presenza di nucleofili, come ammine o alcoli. La sua modifica trifluoroacetile può anche influenzare le proprietà fisiche dei polimeri risultanti, come idrofobicità e stabilità termica. In generale, questo composto funge da strumento prezioso nella sintesi di peptidi e polimeri funzionalizzati, con applicazioni nella somministrazione di farmaci, biomateriali e altri campi della scienza dei materiali.

Formula: C₉H₁₁F₃N₂O₄

InChI: InChI=1/C9H11F3N2O4/c10-9(11,12)7(16)13-4-2-1-3-5-6(15)18-8(17)14-5/h5H,1-4H2,(H,13,16)(H,14,17)/t5-/m0/s1

InChI key: InChIKey=KWNIHCJDDYRQFW-YFKPBYRVSA-N

SMILES: C(CCCNC(C(F)(F)F)=O)[C@H]1C(=O)OC(=O)N1

Sinonimi:

• (S)-N-(4-(2,5-dioxooxazolidin-4-yl)butyl)-2,2,2-trifluoroacetamide
• Acetamide, N-[4-(2,5-dioxo-4-oxazolidinyl)butyl]-2,2,2-trifluoro-, (S)-
• Acetamide, N-[4-[(4S)-2,5-dioxo-4-oxazolidinyl]butyl]-2,2,2-trifluoro-
• H-Lys(Tfa)-Nca
• N-Trifluoroacetyl-<span class="text-smallcaps">L</span>-lysine N-carboxyanhydride
• N-[4-[(4S)-2,5-Dioxo-4-oxazolidinyl]butyl]-2,2,2-trifluoroacetamide
• N-[4-[(4S)-2,5-Dioxooxazolidin-4-Yl]Butyl]-2,2,2-Trifluoro-Acetamide
• N-{4-[(4S)-2,5-dioxo-1,3-oxazolidin-4-yl]butyl}-2,2,2-trifluoroacetamide
• N^ε-Trifluoroacetyl-<span class="text-smallcaps">L</span>-lysine N-carboxyanhydride
• N-Trifluoroacetyl-L-lysine N-carboxyanhydride
• Nε-Trifluoroacetyl-L-lysine N-carboxyanhydride
• 4-[(4S)-2,5-DIOXOOXAZOLIDIN-4-YL]BUTYL]-2,2,2-TRIFLUORO-ACETAMIDE
• Lysine-TFA-NCA
• (S)-N-[4-(2,5-Dioxo-4-oxazolidinyl)butyl]-2,2,2-trifluoroacetaMide
• Lys-NCA
• e-Trifluoroacetyl-Lysine, NCA
• L-Lys(TFA)-NCA
• Nepsilon-Trifluoroacetyl-Nalpha-carboxy-L-lysine Anhydride
• -N-(4-(2,5-Dioxooxazolidin-4-yl)
• N6-Trifluoroacetyl-L-lysine N-Carboxyanhydride
• N-(4-(2,5-Dioxo-4-oxazolidinyl)butyl)-2,2,2-trifluoroacetamide
• N-[3-[(4S)-2,5-dioxooxazolidin-4-yl]propyl]-2,2,2-trifluoro-acetaMide
• L-LYS(TFA)-NCA(42267-27-6)
• L-Lysine-N-Trifluoroacetyl-N-Carboxyanhydride
• N-trifluoroacetyl lysine N-carboxyanhydride

N-[4-[(4S)-2,5-DIOXOOXAZOLIDIN-4-YL]BUTYL]-2,2,2-TRIFLUORO-ACETAMIDE

CAS: 42267-27-6

Formula: C₉H₁₁F₃N₂O₄

Purezza: 95%

Colore e forma: Solid

Peso molecolare: 268.1898

Ref: IN-DA00C0SG

(S)-N-(4-(2,5-Dioxooxazolidin-4-yl)butyl)-2,2,2-trifluoroacetamide

CAS: 42267-27-6

(S)-N-(4-(2,5-Dioxooxazolidin-4-yl)butyl)-2,2,2-trifluoroacetamide

Purezza: 98%

Peso molecolare: 268.19g/mol

Ref: 54-PC99772

(S)-N-(4-(2,5-Dioxooxazolidin-4-yl)butyl)-2,2,2-trifluoroacetamide

CAS: 42267-27-6

Formula: C₉H₁₁F₃N₂O₄

Purezza: 95%

Colore e forma: Solid

Peso molecolare: 268.192

Ref: 10-F225539

N-Trifluoroacetyl-L-lysine N-Carboxyanhydride

CAS: 42267-27-6

Formula: C₉H₁₁F₃N₂O₄

Peso molecolare: 268.19

Ref: 4Z-L-138044

N6-Trifluoroacetyl-L-lysine N-Carboxyanhydride

CAS: 42267-27-6

Applications Used in the synthesis of new arborescent architectures of poly(L-lysine), called lysine dendrigraft (DGL) polymers.  DGL polymers were prepd. through a multiple-generation scheme (up to generation 5) in a weakly acidic aq. medium by polycondensing N.vepsiln.-trifluoroacetyl-L-lysine-N-carboxyanhydride (Lys(Tfa)-NCA) onto the previous generation G(n-1) of DGL, which was used as a macroinitiator.
References Svenson, S., et al.: Adv. Drug Delivery Rev., 57, 2106 (2005), Shen, X., et al.: Org. Biomol. Chem., 5, 3674 (2007),

Formula: C₉H₁₁F₃N₂O₄

Colore e forma: Neat

Peso molecolare: 268.19

Ref: TR-T788530

N6-Trifluoroacetyl-L-lysine N-carboxyanhydride

CAS: 42267-27-6

Trifluoroacetyl-L-lysine N-carboxyanhydride is an N6-trifluoroacetylated lysine derivative that is used in the synthesis of peptides. It is a racemic mixture of L and D forms, which is hydrolyzed to form L-glutamic acid, NH4Cl, and CO2. Trifluoroacetyl-L-lyside N-carboxyanhydride has been shown to be useful in the formation of bonds between amino acids, such as lysine and dipeptides. The compound is also used for the protection of lysine against oxidation during peptide synthesis.

Formula: C₉H₁₁F₃N₂O₄

Purezza: Min. 95%

Colore e forma: White Powder

Peso molecolare: 268.19 g/mol

Ref: 3D-FT28454

(S)-N-[4-(2,5-Dioxooxazolidin-4-yl)butyl]-2,2,2-trifluoroacetamide

CAS: 42267-27-6

Formula: C₉H₁₁F₃N₂O₄

Purezza: >98.0%(HPLC)

Colore e forma: White to Almost white powder to crystal

Peso molecolare: 268.19

Ref: 3B-D5600