CAS 442-51-3

Derivato della harmine

Descrizione:

Derivato della harmine, identificato dal numero CAS 442-51-3, è un composto correlato alla harmina, che è un alcaloide beta-carbolina. Questa sostanza presenta diverse caratteristiche notevoli, incluso il suo ruolo come inibitore reversibile della monoamino ossidasi A (MAO-A), che è significativo nel contesto della neurofarmacologia e delle potenziali applicazioni terapeutiche. I Derivato della harmine sono spesso studiati per le loro proprietà psicoattive e il loro uso potenziale nel trattamento di vari disturbi mentali. Possono anche mostrare attività antiossidanti e anti-infiammatorie, contribuendo al loro interesse nella chimica medicinale. Strutturalmente, i Derivato della harmine contengono tipicamente un sistema di anelli fusi di indolo e piridina, che è cruciale per la loro attività biologica. Inoltre, questi composti possono interagire con vari sistemi di neurotrasmettitori, influenzando l'umore e la cognizione. Lo studio dei Derivato della harmine continua ad evolversi, con ricerche in corso che esplorano il loro potenziale farmacologico e i meccanismi d'azione nel sistema nervoso centrale.

Formula: C₁₃H₁₂N₂O

InChI: InChI=1S/C13H12N2O/c1-8-13-11(5-6-14-8)10-4-3-9(16-2)7-12(10)15-13/h3-7,15H,1-2H3

InChI key: InChIKey=BXNJHAXVSOCGBA-UHFFFAOYSA-N

SMILES: CC1=C2C(C=3C(N2)=CC(OC)=CC3)=CC=N1

Sinonimi:

• 1-Methyl-7-methoxy-β-carboline
• 7-Methoxy-1-methyl-9H-beta-carbolin
• 7-Methoxy-1-methyl-9H-beta-carboline
• 7-Methoxy-1-methyl-9H-pyrido[3,4-b]indole
• 9H-Pyrido(3,4-b)indole, 7-methoxy-1-methyl-
• Banisterin
• Banisterine
• Banisterine Monohydrate
• Harmin
• Harmine
• Leucoharmine
• Telepathin
• Telepathine
• Yagein
• Yageine
• 4-b)indole,7-methoxy-1-methyl-9h-pyrido(
• TELEPATHINE MONOHYDRATE
• 1-Methyl-7-methoxy-beta-carboline
• Telepathien
• PYRIDO(3,4-B)INDOLE,7-METHOXY-1-METHYL-
• Harmine,98+%
• HARMINE FREE BASE
• Garmin
• HARMINE MONOHYDRATE
• HARMAN MONOHYDROCHLORIDE MONOHYDRATE

Harmine

CAS: 442-51-3

Formula: C₁₃H₁₂N₂O

Purezza: >98.0%(T)

Colore e forma: White to Orange to Green powder to crystal

Peso molecolare: 212.25

Ref: 3B-H0001

Harmine

CAS: 442-51-3

Colore e forma: Neat

Ref: 61-FOR2562.00

9H-Pyrido[3,4-b]indole, 7-methoxy-1-methyl-

CAS: 442-51-3

Formula: C₁₃H₁₂N₂O

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 212.2472

Ref: IN-DA00I8E6

Harmine

CAS: 442-51-3

Harmine

Purezza: 98%

Colore e forma: Beige Powder

Peso molecolare: 212.25g/mol

Ref: 54-OR52246

Harmine

CAS: 442-51-3

Formula: C₁₃H₁₂N₂O

Purezza: 97.5 - 102.5 %

Colore e forma: White to off-white crystalline powder

Peso molecolare: 212.25

Ref: 7W-GP4309

Harmine

CAS: 442-51-3

Formula: C₁₃H₁₂N₂O

Purezza: 95%~99%

Peso molecolare: 212.252

Ref: BP-BP0699

Harmine

CAS: 442-51-3

Harmine

Colore e forma: Beige Powder

Peso molecolare: 212.25g/mol

Ref: 54-BIDF1036

Harmine

CAS: 442-51-3

Formula: C₁₃H₁₂N₂O

Peso molecolare: 212.25

Ref: 4Z-H-098001

Harmine

CAS: 442-51-3

Harmine (Telepathine) is an alkaloid isolated from seeds of Peganum harmala.

Formula: C₁₃H₁₂N₂O

Purezza: 98.29% - 99.92%

Colore e forma: Off-White Solid

Peso molecolare: 212.25

Ref: TM-T1711

Harmine

CAS: 442-51-3

Natural alkaloid

Formula: C₁₃H₁₂N₂O

Purezza: ≥ 98.0 % (HPLC)

Colore e forma: Powder

Peso molecolare: 212.25

Ref: 5G-89702

Harmine

CAS: 442-51-3

Applications Harmine is a natural β-carboline alkaloid and a CNS stimulant (1,2). Harmine has been shown to be a potent and selective inhibitor of dual specificity tyrosine phosphorylation regulated kinase 1A (DYRK1A) (3). DYRK1A is a potential therapeutic target for treating diabetes, Down Syndrome, and HIV (4).
References (1) DiStefano, S., et al.: J. Pharmacol. Exp. Ther., 174, 456 (1970)(2) Dos Santos, R. G. and Hallak, J. E. J Psychoactive Drugs. 5,1 (2016) (3) Atteya, R., et al.: Mech Ageing Dev. 6, S0047 (2016)(4) Bol, S. M., et al.: PLoS One. 6, e17190 (2011)

Formula: C₁₃H₁₂N₂O

Colore e forma: White To Brown

Peso molecolare: 212.25

Ref: TR-H105250

Harmine

Prodotto controllato

CAS: 442-51-3

Harmine is a molecule that interacts with DNA by binding to the minor groove, which is the non-helical area of DNA. Harmine has been shown to have cytotoxic properties in murine hepatoma cells, as well as anticancer activity in mouse tumor cells. Harmine also has antiviral and antimicrobial effects, and has been shown to inhibit the growth of human cancer cells. Harmine binds to Toll-like receptor 4 (TLR4), which is a pattern recognition receptor that plays an important role in innate immunity. Harmine inhibits TLR4 signaling, thereby inhibiting inflammatory responses such as acute toxicities. The molecular docking analysis of harmine shows that it has high affinity for polymerase chain reaction (PCR) enzymes and can be used for PCR inhibition studies. The analytical method for harmine was developed using a natural compound crystal structure as a model system.

Formula: C₁₃H₁₂N₂O

Peso molecolare: 212.25 g/mol

Ref: 3D-H-1200

Harmine

CAS: 442-51-3

Formula: C₁₃H₁₂N₂O

Purezza: 99%

Colore e forma: Solid, Very pale yellow to pale yellow powder

Peso molecolare: 212.252

Ref: 10-F047259