CAS 445493-23-2

(4R,7R,8S,9E,11S,12S)-8-(Acetilossi)-4,7-diidrossi-12-[(1E,3E,5S)-6-[(2R,3R)-3-[(1R,2S)-2-idrossi-1-metilbutil]-2-ossiranil]-1,5-dimetil-1,3-esadien-1-il]-7,11-dimetilossaciclododec-9-en-2-one

Descrizione:

La sostanza chimica con il nome "(4R,7R,8S,9E,11S,12S)-8-(Acetilossi)-4,7-diidrossi-12-[(1E,3E,5S)-6-[(2R,3R)-3-[(1R,2S)-2-idrossi-1-metilbutil]-2-ossiranil]-1,5-dimetil-1,3-esadien-1-il]-7,11-dimetilossaciclododec-9-en-2-one" e il numero CAS "445493-23-2" è un composto organico complesso caratterizzato dalla sua intricatissima estereochenica e da molteplici gruppi funzionali. Presenta una struttura biciclica con sostituenti idrossile e acetyloxy, indicando una potenziale attività biologica, possibilmente come prodotto naturale o un suo derivato. La presenza di più centri chirali suggerisce che potrebbe mostrare interazioni stereospecifiche nei sistemi biologici. Inoltre, il composto contiene un anello di ossirano, noto per la sua reattività, in particolare nelle reazioni di addizione nucleofila. La sua complessità strutturale può contribuire a proprietà uniche, come solubilità e stabilità, influenzando le sue potenziali applicazioni in prodotti farmaceutici o agrochimici. In generale, questo composto esemplifica la diversità delle molecole organiche e i loro potenziali ruoli in vari processi chimici e biologici.

Formula: C₃₀H₄₈O₈

InChI: InChI=1S/C30H48O8/c1-8-24(33)21(5)29-25(37-29)16-18(2)10-9-11-19(3)28-20(4)12-13-26(36-22(6)31)30(7,35)15-14-23(32)17-27(34)38-28/h9-13,18,20-21,23-26,28-29,32-33,35H,8,14-17H2,1-7H3/b10-9+,13-12+,19-11+/t18-,20+,21-,23-,24+,25-,26+,28-,29-,30-/m1/s1

InChI key: InChIKey=SDOUORKJIJYJNW-QHOUZYGJSA-N

SMILES: C([C@@H](/C=C/C=C(\C)/[C@@H]1[C@@H](C)/C=C/[C@H](OC(C)=O)[C@](C)(O)CC[C@@H](O)CC(=O)O1)C)[C@@H]2[C@@]([C@@H]([C@H](CC)O)C)(O2)[H]

Sinonimi:

• Oxacyclododec-9-en-2-one, 8-(acetyloxy)-4,7-dihydroxy-12-[(1E,3E,5S)-6-[(2R,3R)-3-[(1R,2S)-2-hydroxy-1-methylbutyl]-2-oxiranyl]-1,5-dimethyl-1,3-hexadien-1-yl]-7,11-dimethyl-, (4R,7R,8S,9E,11S,12S)-
• 11107B
• Oxacyclododec-9-en-2-one, 8-(acetyloxy)-4,7-dihydroxy-12-[(1E,3E,5S)-6-[(2R,3R)-3-[(1R,2S)-2-hydroxy-1-methylbutyl]oxiranyl]-1,5-dimethyl-1,3-hexadienyl]-7,11-dimethyl-, (4R,7R,8S,9E,11S,12S)-
• (4R,7R,8S,9E,11S,12S)-8-(Acetyloxy)-4,7-dihydroxy-12-[(1E,3E,5S)-6-[(2R,3R)-3-[(1R,2S)-2-hydroxy-1-methylbutyl]-2-oxiranyl]-1,5-dimethyl-1,3-hexadien-1-yl]-7,11-dimethyloxacyclododec-9-en-2-one
• Pladienolide B

Pladienolide B

CAS: 445493-23-2

Formula: C₃₀H₄₈O₈

Peso molecolare: 536.6973

Ref: IN-DA00DKMX

Pladienolide B

CAS: 445493-23-2

Pladienolide B, a macrolide from Streptomyces, inhibits spliceosome's SF3B1, causing necrosis and antitumor effects for leukemia and lymphoid studies.

Formula: C₃₀H₄₈O₈

Purezza: 98.27% - 98.27%

Colore e forma: Solid

Peso molecolare: 536.7

Ref: TM-T16551

Pladienolide B

CAS: 445493-23-2

Pladienolide B is a natural macrocyclic compound, which is a secondary metabolite derived from the culture broth of the bacterium Streptomyces platensis. It functions as a selective inhibitor of the spliceosome, a complex responsible for pre-mRNA splicing. By binding to the SF3b subunit of the spliceosome, Pladienolide B disrupts normal splicing processes, leading to alterations in gene expression. This disruption affects the growth and survival of cancer cells, demonstrating significant antitumor activity in various cancer models.Pladienolide B's unique mechanism of targeting the spliceosome makes it a subject of interest in cancer research, particularly for malignancies resistant to conventional therapies. Its efficacy in preclinical studies highlights its potential as a lead compound for the development of novel anticancer drugs. Researchers investigate its applications in targeting specific cancer types, exploring synergies with other treatments, and understanding resistance mechanisms, making it an important tool in both basic research and therapeutic exploration.

Formula: C₃₀H₄₈O₈

Peso molecolare: 536.7 g/mol

Ref: 3D-FP184560