CAS 448184-48-3

2-[2-Etossi-5-[(4-etil-4-ossido-1-piperazinil)sulfonil]fenil]-5-metil-7-propilimidazo[5,1-f][1,2,4]triazin-4(1H)-one

Descrizione:

La sostanza chimica nota come "2-[2-Etossi-5-[(4-etil-4-ossido-1-piperazinil)sulfonil]fenil]-5-metil-7-propilimidazo[5,1-f][1,2,4]triazin-4(1H)-one," con il numero CAS 448184-48-3, è un composto organico complesso caratterizzato dalla sua struttura multifunzionale. Presenta un nucleo di imidazotriazina, noto per la sua potenziale attività biologica, in particolare in chimica medicinale. La presenza di un gruppo etossido e di un moiety sulfonilico suggerisce che il composto possa mostrare solubilità in solventi organici e potrebbe interagire con bersagli biologici attraverso legami idrogeno e altre interazioni non covalenti. L'anello di piperazina contribuisce alle sue proprietà farmacologiche, potenzialmente migliorando la sua capacità di attraversare le membrane biologiche. Inoltre, la presenza di vari sostituenti, come i gruppi etile e propile, può influenzare la sua lipofilia e l'attività biologica complessiva. Questo composto potrebbe essere di interesse nello sviluppo di farmaci, in particolare nei campi dell'oncologia o delle malattie infettive, sebbene specifiche attività biologiche richiederebbero un'indagine empirica.

Formula: C₂₃H₃₂N₆O₅S

InChI: InChI=1S/C23H32N6O5S/c1-5-8-20-24-16(4)21-23(30)25-22(26-28(20)21)18-15-17(9-10-19(18)34-7-3)35(32,33)27-11-13-29(31,6-2)14-12-27/h9-10,15H,5-8,11-14H2,1-4H3,(H,25,26,30)

InChI key: InChIKey=GXUGEZIHENHAGP-UHFFFAOYSA-N

SMILES: O(CC)C1=C(C=C(S(=O)(=O)N2CCN(CC)(=O)CC2)C=C1)C=3NN4C(C(=O)N3)=C(C)N=C4CCC

Sinonimi:

• Imidazo[5,1-f][1,2,4]triazin-4(1H)-one, 2-[2-ethoxy-5-[(4-ethyl-4-oxido-1-piperazinyl)sulfonyl]phenyl]-5-methyl-7-propyl-
• 2-[2-Ethoxy-5-[(4-ethyl-4-oxido-1-piperazinyl)sulfonyl]phenyl]-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(1H)-one
• Piperazine, 1-[[3-(1,4-dihydro-5-methyl-4-oxo-7-propylimidazo[5,1-f][1,2,4]triazin-2-yl)-4-ethoxyphenyl]sulfonyl]-4-ethyl-, 4-oxide
• Vardena hydrochloride impurity D
• 4-((4-ethoxy-3-(5-methyl-4-oxo-7-propyl-1,4-dihydroimidazo[5,1-f][1,2,4]triazin-2-yl)phenyl)sulfonyl)-1-ethylpiperazine 1-oxide
• Vardenafil Impurity 9(Vardenafil N-Oxide)
• Vardenafil N-Oxide Impurity

Vardenafil Related Compound D (2-{2-Ethoxy-5-[(4-ethyl-4-oxidopiperazin-1-yl)sulfonyl]phenyl}-5-methyl-7-propyl-imidazo[5,1-f][1,2,4]triazin-4(3H)-one)

CAS: 448184-48-3

Sulfonamides, nesoi

Formula: C₂₃H₃₂N₆O₅S

Colore e forma: White Powder

Peso molecolare: 504.21549

Ref: 45-1711064

Vardenafil USP Related Compound D (Vardenafil N-Oxide)

CAS: 448184-48-3

Formula: C₂₃H₃₂N₆O₅S

Colore e forma: White To Off-White Solid

Peso molecolare: 504.61

Ref: 4Z-V-0522

Vardenafil N-oxide

CAS: 448184-48-3

Vardenafil N-oxide

Purezza: 98%

Ref: 54-OR1039828

Vardenafil N-Oxide

Prodotto controllato

CAS: 448184-48-3

Formula: C₂₃H₃₂N₆O₅S

Colore e forma: Neat

Peso molecolare: 504.60

Ref: 86-MM1569.03

Vardenafil N-Oxide

Prodotto controllato

CAS: 448184-48-3

Applications Vardenafil N-Oxide is an impurity compound of Vardenafil Hydrochloride. It is used in the treatment of erectile dysfunction. It also functions an inhibitor of phosphodiestrase type 5(PDE-5) enzyme.
References Reddy, V. V., et al.: Synth. Commun., 42, 3513 (2012)

Formula: C₂₃H₃₂N₆O₅S

Colore e forma: Neat

Peso molecolare: 504.60

Ref: TR-V098010

Vardenafil N-oxide

CAS: 448184-48-3

Vardenafil N-oxide is a medicinal compound that is an analog of vardenafil, a drug used to treat erectile dysfunction. This compound has been identified as a potential anticancer agent due to its ability to inhibit the activity of certain kinases involved in tumor growth and survival. Vardenafil N-oxide has been shown to induce apoptosis (cell death) in cancer cells, particularly those of Chinese hamster ovary origin. Additionally, this compound has demonstrated inhibitory effects on the growth of human prostate cancer cells and has been found in the urine of patients undergoing treatment with cysteamine, a medication used for the treatment of cystinosis. Overall, Vardenafil N-oxide holds significant promise for the development of novel cancer therapies as an inhibitor of key signaling pathways involved in tumor progression.

Formula: C₂₃H₃₂N₆O₅S

Purezza: Min. 95%

Peso molecolare: 504.6 g/mol

Ref: 3D-YSA18448

Vardenafil USP Related Compound D

CAS: 448184-48-3

Formula: C₂₃H₃₂N₆O₅S

Peso molecolare: 504.61

Ref: ST-EA-CP-V28019