CAS 4562-36-1

Gitossina

Descrizione:

Gitossina, con il numero CAS 4562-36-1, è un glicoside cardiaco derivato dalla specie vegetale Digitalis, comunemente nota come digitale. È caratterizzato dalla sua capacità di inibire l'enzima Na+/K+ ATPasi, portando a un aumento delle concentrazioni intracellulari di sodio e calcio nelle cellule cardiache. Questo meccanismo aumenta la forza delle contrazioni cardiache, rendendolo utile nel trattamento di alcune condizioni cardiache, come la fibrillazione atriale e l'insufficienza cardiaca. Gitossina presenta un indice terapeutico ristretto, il che significa che la differenza tra una dose efficace e una dose tossica è piccola, richiedendo un attento monitoraggio dei livelli ematici durante il trattamento. La sostanza è anche nota per i suoi potenziali effetti collaterali, che possono includere disturbi gastrointestinali, cambiamenti visivi e aritmie. Come altri glicosidi cardiaci, la farmacocinetica di Gitossina può essere influenzata da fattori come la funzione renale e le interazioni con altri farmaci. A causa dei suoi effetti potenti e della potenziale tossicità, Gitossina deve essere utilizzato sotto stretta supervisione medica.

Formula: C₄₁H₆₄O₁₄

InChI: InChI=1S/C41H64O14/c1-19-36(47)27(42)14-33(50-19)54-38-21(3)52-34(16-29(38)44)55-37-20(2)51-32(15-28(37)43)53-24-8-10-39(4)23(13-24)6-7-26-25(39)9-11-40(5)35(22-12-31(46)49-18-22)30(45)17-41(26,40)48/h12,19-21,23-30,32-38,42-45,47-48H,6-11,13-18H2,1-5H3/t19-,20-,21-,23-,24+,25+,26-,27+,28+,29+,30+,32+,33+,34+,35+,36-,37-,38-,39+,40-,41+/m1/s1

InChI key: InChIKey=LKRDZKPBAOKJBT-CNPIRKNPSA-N

SMILES: O[C@@]12[C@]3([C@@]([C@]4(C)[C@](CC3)(C[C@@H](O[C@H]5C[C@H](O)[C@H](O[C@H]6C[C@H](O)[C@H](O[C@H]7C[C@H](O)[C@H](O)[C@@H](C)O7)[C@@H](C)O6)[C@@H](C)O5)CC4)[H])(CC[C@]1(C)[C@H]([C@@H](O)C2)C8=CC(=O)OC8)[H])[H]

Sinonimi:

• (3beta,5beta,16beta)-3-{[2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl]oxy}-14,16-dihydroxycard-20(22)-enolide
• (3beta,5beta,9xi,16beta)-3-{[(4xi)-2,6-dideoxy-D-erythro-hexopyranosyl-(1->4)-2,6-dideoxy-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl]oxy}-14,16-dihydroxycard-20(22)-enolide
• (3β,5β,16β)-3-[(O-2,6-Dideoxy-β-<span class="text-smallcaps">D</smallcap>-ribo-hexopyranosyl-(1→4)-O-2,6-dideoxy-β-<smallcap>D</smallcap>-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-<smallcap>D</span>-ribo-hexopyranosyl)oxy]-14,16-dihydroxycard-20(22)-enolide
• 3-{[2,6-Dideoxyhexopyranosyl-(1->4)-2,6-Dideoxyhexopyranosyl-(1->4)-2,6-Dideoxyhexopyranosyl]Oxy}-14,16-Dihydroxycard-20(22)-Enolide
• Anhydrogitalin
• Bigitalin
• Brn 0077015
• Card-20(22)-enolide, 3-((O-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1-4)-O-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1-4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl)oxy)-14,16-dihydroxy-, (3beta,5beta,16beta)- (9CI)
• Card-20(22)-enolide, 3-[(O-2,6-dideoxy-β-<span class="text-smallcaps">D</smallcap>-ribo-hexopyranosyl-(1→4)-O-2,6-dideoxy-β-<smallcap>D</smallcap>-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-<smallcap>D</span>-ribo-hexopyranosyl)oxy]-14,16-dihydroxy-, (3β,5β,16β)-
• Gitoksin
• Gitoxigenin-tridigitoxosid
• Gitoxigenin-tridigitoxosid [German]
• Gitoxim
• Gitoxoside
• Nsc 95099
• Pseudodigitoixn
• Pseudodigitoxin
• Gitoxin
• Card-20(22)-enolide, 3-[(O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-D-ribo-hexopyranosyl)oxy]-14,16-dihydroxy-, (3β,5β,16β)-
• (3β,5β,16β)-3-[(O-2,6-Dideoxy-β-D-ribo-hexopyranosyl-(1→4)-O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-D-ribo-hexopyranosyl)oxy]-14,16-dihydroxycard-20(22)-enolide
• Gitoxin extrapure, 98%
• 20(22),5BETA-CARDENOLID-3BETA,14BETA,16BETA-TRIOL 3BETA-[O-BETA-D-DIGITOXOPYRANOSYL-(1->4)-O-BETA-D-DIGITOXOPYRANOSYL-(1->4)-O-BETA-D-DIGITOXOPYRANOSIDE]
• Gitoxin CRS
• Digoxin Impurity 15
• Anhydrogitalin, Pseudodigitoxin
• 16-Hydroxydigitoxin
• GINSENOSIDES KIT
• 3β-[[4-O-[4-O-(2,6-Dideoxy-β-D-ribo-hexopyranosyl)-2,6-dideoxy-β-D-ribo-hexopyranosyl]-2,6-dideoxy-β-D-ribo-hexopyranosyl]oxy]-14,16β-dihydroxy-5β-card-20(22)-enolide
• Digoxin EP Impurity B
• Digoxin IMpurity B
• Gitoxin (50 mg)
• ACETYL GITOXIN, 16-(RG)
• Gitoxin for Purity RS

Gitoxin

CAS: 4562-36-1

Gitoxin analytical standard provided with w/w absolute assay, to be used for quantitative titration.

Formula: C₄₁H₆₄O₁₄

Purezza: (HPLC) ≥98%

Colore e forma: Powder

Peso molecolare: 780.95

Ref: 11-0823S

GITOXIN CRS

CAS: 4562-36-1

GITOXIN CRS

Formula: C₄₁H₆₄O₁₄

Colore e forma: Crystalline Powder. White. Powder.

Peso molecolare: 780.9385

Ref: 41-G0300000

Gitoxin

CAS: 4562-36-1

Gitoxin

Purezza: 95%

Peso molecolare: 780.94g/mol

Ref: 54-OR1075482

Gitoxin

CAS: 4562-36-1

Gitoxin is a natural Na⁺/K⁺-ATPase inhibitor and metabolite of digitoxin, antiarrhythmic with μM-level inhibition of human erythrocyte isoenzymes.

Formula: C₄₁H₆₄O₁₄

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 780.94

Ref: TM-TN4134

Digoxin EP Impurity B

CAS: 4562-36-1

Formula: C₄₁H₆₄O₁₄

Peso molecolare: 780.95

Ref: 4Z-D-753

Gitoxin

CAS: 4562-36-1

Formula: C₄₁H₆₄O₁₄

Purezza: ≥ 95%

Colore e forma: White solid

Peso molecolare: 780.94

Ref: 7W-GW0261

Gitoxin for Purity RS

CAS: 4562-36-1

Colore e forma: White Solid Crystalline Powder

Ref: 2K-1044000021

Gitoxin

CAS: 4562-36-1

Gitoxin is a protein analog that has been shown to increase the strength of heart tissue. It has been shown to be effective in treating congestive heart failure, which is characterized by symptoms such as shortness of breath and fatigue. Gitoxin also inhibits inflammatory bowel disease, including Crohn's disease and ulcerative colitis. Gitoxin is a growth factor that stimulates the proliferation of human serum cells, with an effect on basic fibroblast growth factor (bFGF). Gitoxin has been shown to have cardiac effects and may inhibit cardiac arrhythmias by binding to the papillary muscle. There are kinetic studies that show gitoxin binding to the cardiac potassium channels and activating them.

Formula: C₄₁H₆₄O₁₄

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 780.96 g/mol

Ref: 3D-FG08665

Gitoxin extrapure, 98%

CAS: 4562-36-1

Purezza: -98%

Ref: SR-56397

Gitoxin

CAS: 4562-36-1

Purezza: 98%

Peso molecolare: 780.9489746

Ref: 10-F618825

Digoxin EP Impurity B

CAS: 4562-36-1

Formula: C₄₁H₆₄O₁₄

Peso molecolare: 780.9

Ref: ST-EA-CP-D1200002

Gitoxin

Prodotto controllato

CAS: 4562-36-1

Stability Hygroscopic
Applications Gitoxin acts as in inhibitor of the sodium and potassium ion channels, interfering with ATPase activity and used in cancer treatment as a growth inhibitor.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Colovic, M. et al.: Russ. J. Phys. Chem. A., 83, 1602 (2009); Banuls, L. et al.: Mol. Canc., 12, 33 (2013);

Formula: C₄₁H₆₄O₁₄

Colore e forma: Neat

Peso molecolare: 780.94

Ref: TR-G388750