CAS 465-21-4

Bufalina

Descrizione:

Bufalina è un potente glicoside cardiaco derivato dalla pelle delle rane, in particolare della specie Bufo. È classificato nella categoria più ampia dei bufadienolidi, noti per la loro capacità di inibire l'enzima Na+/K+ ATPasi, portando a un aumento dei livelli di calcio intracellulare e a una maggiore contrattilità cardiaca. Bufalina presenta una varietà di attività biologiche, comprese proprietà anti-tumorali, anti-infiammatorie e antivirali, rendendolo un argomento di interesse nella ricerca farmacologica. Il composto è tipicamente caratterizzato dalla sua struttura simile a uno steroide, con un anello di lattone e più gruppi idrossilici, che contribuiscono alla sua attività biologica. Bufalina è lipofilo, permettendogli di attraversare facilmente le membrane cellulari, ed è stato studiato per le sue potenziali applicazioni terapeutiche, in particolare nel trattamento di alcuni tumori e condizioni cardiache. Tuttavia, il suo uso è limitato dalla sua tossicità e dai potenziali effetti collaterali, richiedendo una considerazione attenta in contesti clinici. In generale, Bufalina rappresenta un esempio affascinante di un prodotto naturale con un significativo potenziale farmacologico.

Formula: C₂₄H₃₄O₄

InChI: InChI=1/C24H34O4/c1-22-10-7-17(25)13-16(22)4-5-20-19(22)8-11-23(2)18(9-12-24(20,23)27)15-3-6-21(26)28-14-15/h3,6,14,16-20,25,27H,4-5,7-13H2,1-2H3/t16-,17+,18-,19?,20?,22+,23-,24+/m1/s1

InChI key: InChIKey=QEEBRPGZBVVINN-BMPKRDENSA-N

SMILES: O[C@@]12[C@@](C)([C@H](CC1)C=3C=CC(=O)OC3)CC[C@]4([C@]2(CC[C@]5([C@]4(C)CC[C@H](O)C5)[H])[H])[H]

Sinonimi:

• (3Beta,5Beta,8Xi,9Xi)-3,14-Dihydroxybufa-20,22-Dienolide
• (3β,5β)-3,14-Dihydroxybufa-20,22-dienolide
• 3,14-Dihydroxybufa-20,22-Dienolide
• 5β-Bufa-20,22-dienolide, 3β,14-dihydroxy-
• B 0261
• Bufa-20,22-dienolide, 3,14-dihydroxy-, (3β,5β)-
• NSC 89595
• Bufalin
• Bufalin, >=98%
• 5BETA,20[22]-BUFADIENOLIDE-3BETA,14-DIOL
• 22-dienolide,3-beta,14-dihydroxy-5-beta-bufa-2
• 5-(3,14-Dihydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl)pyran-2-one
• Bufalin std.
• BUFALIN: BUFA-20,22-DIENOLIDE, 3,14-DIHYDROXY-, (3B,5B)-,
• Bufalin,3β,14-Dihydroxy-5β,20(22)-bufadienolide, 5β,20(22)-Bufadienolide-3β,14-diol
• 5-(3,14-Dihydroxy-13-methyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-pyran-2-one
• 3β,14-Dihydroxy-5β,20(22)-bufadienolide
• 22-dienolide,3,14-dihydroxy-,(3-beta,5-beta)-bufa-2
• 5β,20(22)-Bufadienolide-3β,14-diol
• BUFALIN90%,99%
• (3β,5β)-3,14-Dihydroxy-bufa-20,22-dienolide
• Bufa-20,22-dienolide, 3,14-dihydroxy-, (3-beta,5-beta)-
• 3β,14-Dihydroxy-5β,20(22)-bufadienolide, 5β,20(22)-Bufadienolide-3β,14-diol
• 3BETA,14-DIHYDROXY-5BETA,20[22]-BUFADIENOLIDE
• 3-b,14-Dihydroxy-5-beta-bufa-20,22-dienolide
• 3-BETA-14-DIHYDROXY-5-BETA-BUFA-20,22-DIENOLIDE

(3β,5β)-3,14-Dihydroxybufa-20,22-dienolide

CAS: 465-21-4

Formula: C₂₄H₃₄O₄

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 386.5244

Ref: IN-DA00I8KR

Bufalin

CAS: 465-21-4

Bufalin

Purezza: ≥98%

Peso molecolare: 386.52g/mol

Ref: 54-BUP13200

Bufalin

CAS: 465-21-4

Bufalin a major digoxin-like immunoreactive component of the Chinese medicine Chan Su; has been shown to exert a potential for anticancer activity against various human cancer cell lines in vitro. Bufalin is a potent small-molecule inhibitor of the steroid receptor coactivators steroid receptor coactivator (SRC)-3 and SRC-1, it also as a potentially broad-spectrum small-molecule inhibitor for cancer. Bufalin can partly reverse the MDR of K562/VCR cells, with a possible mechanism of down-regulating MRP1 expression and activating apoptosis pathway by altering Bcl-xL/Bax ratio.

Formula: C₂₄H₃₄O₄

Purezza: 95%~99%

Peso molecolare: 386.532

Ref: BP-BP0288

Bufalin

CAS: 465-21-4

Bufalin: a cardiotonic, antineoplastic glycoside in ChanSu; from toad venom; inhibits Na+/K+-ATPase, triggers apoptosis via MAPK pathway.

Formula: C₂₄H₃₄O₄

Purezza: 98% - 99.8%

Colore e forma: White Solid

Peso molecolare: 386.52

Ref: TM-T1719

Bufalin

CAS: 465-21-4

Formula: C₂₄H₃₄O₄

Purezza: (HPLC) ≥ 98.0%

Colore e forma: White to off-white powder

Peso molecolare: 386.52

Ref: 7W-GL7257

Bufalin

CAS: 465-21-4

Lactone

Formula: C₂₄H₃₄O₄

Purezza: ≥ 95.0 % (HPLC)

Colore e forma: Powder

Peso molecolare: 386.53

Ref: 5G-89587

Bufalin

CAS: 465-21-4

Purezza: 99.86%

Peso molecolare: 386.532

Ref: 10-F048876

Bufalin

CAS: 465-21-4

Applications A bufadienolide derivative, cardiac steroid, a component of bufadienolides present in the traditional Chinese medicine Chan'su, used therapeutically for the treatment of heart disease, also has been reported as a protective factor in many tumors.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Wang, B., et al.: Biol. Pharm. Bull., 34, 967 (2011), Song, C., et al.: Xiandai Zhongliu Yixue, 18, 1863, 2010.

Formula: C₂₄H₃₄O₄

Colore e forma: Neat

Peso molecolare: 386.52

Ref: TR-B689510

Bufalin

CAS: 465-21-4

Bufalin is a bufadienolide compound, which is a type of steroid derived primarily from toad venom, specifically from the skin and parotid venom glands of the toad species Bufo gargarizans. Its mode of action involves the inhibition of Na+/K+-ATPase, an enzyme critical for maintaining the electrochemical gradient across cell membranes. By disrupting this gradient, Bufalin affects cellular ion homeostasis and induces apoptosis in various cancer cell lines.

Formula: C₂₄H₃₄O₄

Purezza: Min. 95%

Colore e forma: White Powder

Peso molecolare: 386.52 g/mol

Ref: 3D-FB19349

Bufalin-2,2,3,4,4-d5

Prodotto controllato

CAS: 465-21-4

Applications Isotope labelled Bufalin (B689510) is a Bufadienolide derivative, cardiac steroid, a component of bufadienolides present in the traditional Chinese medicine Chan'su, used therapeutically for the treatment of heart disease, also has been reported as a protective factor in many tumors.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Wang, B., et al.: Biol. Pharm. Bull., 34, 967 (2011), Song, C., et al.: Xiandai Zhongliu Yixue, 18, 1863, 2010.

Formula: C₂₄H₂₉D₅O₄

Colore e forma: Neat

Peso molecolare: 391.56

Ref: TR-B689512