CAS 469-83-0
:Cafestol
Descrizione:
Cafestol è un composto naturale che si trova principalmente nel caffè, in particolare nelle infusioni di caffè non filtrato. È un diterpene, specificamente un tipo di labdano, ed è noto per la sua struttura simile ai lipidi. Cafestol è riconosciuto per i suoi potenziali effetti sulla salute, inclusa la sua capacità di aumentare i livelli di colesterolo nel sangue, che è stato oggetto di ricerca riguardo al consumo di caffè e alla salute cardiovascolare. Il composto è anche noto per le sue proprietà antiossidanti, contribuendo ai benefici generali per la salute associati al caffè. Cafestol è solubile in solventi organici ma ha una solubilità limitata in acqua, il che è tipico di molti composti lipofili. La sua presenza nel caffè varia significativamente a seconda del metodo di preparazione; ad esempio, metodi come la French press o il caffè turco trattengono più Cafestol rispetto al caffè filtrato. Comprendere le caratteristiche di Cafestol è essenziale per valutare il suo impatto sulla salute e sulla nutrizione, così come il suo ruolo nella complessa chimica del caffè.
Formula:C20H28O3
InChI:InChI=1/C20H28O3/c1-18-7-5-16-14(6-9-23-16)15(18)4-8-19-10-13(2-3-17(18)19)20(22,11-19)12-21/h6,9,13,15,17,21-22H,2-5,7-8,10-12H2,1H3/t13?,15-,17+,18-,19+,20+/m1/s1
InChI key:InChIKey=DNJVYWXIDISQRD-HWUKTEKMSA-N
SMILES:C[C@]12[C@]3([C@]4(C[C@]([C@](CO)(O)C4)(CC3)[H])CC[C@@]1(C5=C(CC2)OC=C5)[H])[H]
Sinonimi:- (3bS,5aS,7R,8R,10aR,10bS)-3b,4,5,6,7,8,9,10,10a,10b,11,12-Dodecahydro-7-hydroxy-10b-methyl-5a,8-methano-5aH-cyclohepta[5,6]naphtho[2,1-b]furan-7-methanol
- (3bS,5aS,7R,8R,10aR,10bS)-7-(hydroxymethyl)-10b-methyl-3b,4,5,6,7,8,9,10,10a,10b,11,12-dodecahydro-5a,8-methanocyclohepta[5,6]naphtho[2,1-b]furan-7-ol
- (3bS,5aS,7R,8S,10aR,10bS)-7-(hydroxymethyl)-10b-methyl-3b,4,5,6,7,8,9,10,10a,10b,11,12-dodecahydro-5a,8-methanocyclohepta[5,6]naphtho[2,1-b]furan-7-ol
- 5a,8-Methano-5aH-cyclohepta(5,6)naphtho(2,1-b)furan-7-methanol, 3b,4,5,6,7,8,9,10,10a,10b,11,12-dodecahydro-7-hydroxy-10b-methyl-, (3bS,5aS,7R,8R,10aR,10bS)-
- 5a,8-Methano-5aH-cyclohepta(5,6)naphtho(2,1-b)furan-7-methanol, 3b,4,5,6,7,8,9,10,10a,10b,11,12-dodecahydro-7-hydroxy-10b-methyl-, (3bS-(3balpha,5abeta,7beta,8beta,10aalpha,10bbeta))-
- 5a,8-Methano-5aH-cyclohepta[5,6]naphtho[2,1-b]furan-7-methanol, 3b,4,5,6,7,8,9,10,10a,10b,11,12-dodecahydro-7-hydroxy-10b-methyl-, [3bS-(3bα,5aβ,7β,8β,10aα,10bβ)]-
- Cafesterol
- Ccris 1518
- Cafestol
- 3bα,4,5,6,7,8,9,10,10aα,10b,11,12-Dodecahydro-7β-hydroxy-10bβ-methyl-5aβ,8β-methano-5aH-cyclohepta[5,6]naphtho[2,1-b]furan-7α-methanol
- Cafestol (>85%)
- Vedi altri sinonimi
Ordinare per
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10 prodotti.
Cafestol
CAS:<p>Natural extract from coffee beans which induces glutathione S-transferase</p>Formula:C20H28O3Colore e forma:White to off white, PowderPeso molecolare:316.44Cafestol
CAS:Formula:C20H28O3Purezza:≥ 98.0%Colore e forma:White to off-white powderPeso molecolare:316.44Cafestol
CAS:Cafestol has anticarcinogenic, peripheral antinociceptive and anti-inflammatory activities, it inhibits Cyclic-Strain-induced interleukin-8, intercellular adhesion molecule-1, and monocyte chemoattractant protein-1 production in vascular endothelial cells. Cafestol is a novel extracellular signal-regulated kinase inhibitor with AP-1-targeted inhibition of prostaglandin E2 production in lipopolysaccharide-activated macrophages. Cafestol acts as an agonist ligand for both FXR and PXR, and this may contribute to its impact on cholesterol homeostasis. Cafestol has protective effects against the CCl(4)-induced hepatotoxicity, which possibly involve mechanisms related to its ability to block the CYP2E1-mediated CCl(4) bioactivation and free radical scavenging effects. Cafestol has antidiabetic activity, it increases glucose-stimulated insulin secretion in vitro and increases glucose uptake in human skeletal muscle cells. Cafestol also has a weak inhibitory effect on osteoclastogenesis and promotes osteoblast differentiation.Formula:C20H28O3Purezza:95%~99%Peso molecolare:316.441CAFESTOL
CAS:<p>Cafestol, an ERK inhibitor, suppresses PGE2 and COX-2 by blocking NF-kB in LPS-stimulated RAW264.7 cells.</p>Formula:C20H28O3Purezza:97.06% - 99.08%Colore e forma:SolidPeso molecolare:316.43Cafestol
CAS:Oxygen-heterocyclic compoundFormula:C20H28O3Purezza:≥ 98.0 % (HPLC)Colore e forma:PowderPeso molecolare:316.44Cafestol (>85%)
CAS:Prodotto controllato<p>Applications Cafestol is a diterpene molecule that displays anti-carcinogenic properties in studies.<br>References Higgins, L.G. et al.: Tox. App. Pharma., 226, 328 (2008); Schilter, B. et al.: Carcinogenesis, 17, 2377 (1996);<br></p>Formula:C20H28O3Purezza:>85%Colore e forma:NeatPeso molecolare:316.43Cafestol
CAS:<p>Cafestol is a diterpene compound, which is primarily sourced from coffee beans. It is found in the oily fraction of coffee, particularly in unfiltered types like French press and Turkish coffee. Its mode of action involves influencing lipid metabolism in the liver. Specifically, cafestol acts as an agonist for certain nuclear receptors, including FXR and PXR, which play a role in bile acid regulation and lipid homeostasis.Cafestol is known to have a notable impact on cholesterol levels. It causes an increase in serum cholesterol by reducing the excretion of bile acids, consequently enhancing cholesterol reabsorption. Due to its pronounced effects on cholesterol metabolism, cafestol is a compound of interest in cardiovascular research, especially in the context of dietary factors influencing heart health. Scientists are exploring its broader implications on lipid-related diseases and how modifying coffee preparation methods can mitigate its impact on health.</p>Formula:C20H28O3Purezza:Min. 95%Colore e forma:PowderPeso molecolare:316.43 g/mol
